Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice.
Diabetic kidney disease
Glutathione
Inflammation
MALDI-MSI
Nrf2
Oxidative stress
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
25
07
2022
revised:
13
10
2022
accepted:
24
10
2022
pubmed:
7
11
2022
medline:
15
12
2022
entrez:
6
11
2022
Statut:
ppublish
Résumé
Oxidative stress is an essential component in the progression of diabetic kidney disease (DKD), and the transcription factor NF-E2-related factor-2 (Nrf2) plays critical roles in protecting the body against oxidative stress. To clarify the roles of Nrf2 in protecting against DKD, in this study we prepared compound mutant mice with diabetes and loss of antioxidative defense. Specifically, we prepared compound Ins2
Identifiants
pubmed: 36335764
pii: S2213-2317(22)00297-X
doi: 10.1016/j.redox.2022.102525
pmc: PMC9641024
pii:
doi:
Substances chimiques
Glutathione
GAN16C9B8O
Kelch-Like ECH-Associated Protein 1
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102525Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.