Fast determination of free metronidazole in rat plasma and peritoneal fluid using HPLC-UV method.
HPLC-UV
bioanalytical validation
metronidazole
microdialysis
peritoneum
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
31
10
2022
received:
22
08
2022
accepted:
01
11
2022
pubmed:
7
11
2022
medline:
18
1
2023
entrez:
6
11
2022
Statut:
ppublish
Résumé
Peritonitis refers to the inflammatory reaction of the peritoneum to aggression. In addition, it contributes significantly to sepsis. The presence of free concentrations of antimicrobials above the minimum inhibitory concentration at the site of infection is critical to therapeutic response. Metronidazole (MTZ) is an antimicrobial used to treat peritonitis because of its effectiveness against anaerobic microorganisms. This study investigates free MTZ concentrations in peritoneal microdialysate in Wistar rats. A C
Substances chimiques
Metronidazole
140QMO216E
Anti-Infective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5543Informations de copyright
© 2022 John Wiley & Sons, Ltd.
Références
Bakare-Odunola, M. T., Mustapha, K. B., Garba, M., Obodozie, O. O., & Enemali, I. S. (2010). The influence of Nifadin®, Niprisan® and Niprd® on the pharmacokinetics of metronidazole in rats. European Journal of Drug Metabolism and Pharmacokinetics, 35(1-2), 55-58. https://doi.org/10.1007/s13318-010-0008-7
Bendesky, A., & Menéndez, D. (2001). Metronidazol: Una visión integral Andrés. Revista de La Facultad de Medicina, 44(6), 255-259.
Chauzy, A., Lamarche, I., Adier, C., Couet, W., & Marchand, S. (2018). Microdialysis study of aztreonam-avibactam distribution in peritoneal fluid and muscle of rats with or without experimental peritonitis. Antimicrobial Agents and Chemotherapy, 62(10), 1-8. https://doi.org/10.1128/AAC.01228-18
Daskalopoulou, D., Kankam, J., Ambe, P. C., & Zarras, K. (2020). Single-center retrospective analysis of the outcomes of patients undergoing staged peritoneal lavage for secondary peritonitis. World Journal of Surgery, 44(7), 2185-2190. https://doi.org/10.1007/s00268-020-05455-9
Dingsdag, S. A., & Hunter, N. (2018). Metronidazole: An update on metabolism, structure-cytotoxicity and resistance mechanisms. Journal of Antimicrobial Chemotherapy, 73(2), 265-279. https://doi.org/10.1093/jac/dkx351
Dorn, C., Kratzer, A., Schießer, S., Kees, F., Wrigge, H., & Simon, P. (2019). Determination of total or free cefazolin and metronidazole in human plasma or interstitial fluid by HPLC-UV for pharmacokinetic studies in man. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1118-1119(2), 51-54. https://doi.org/10.1016/j.jchromb.2019.04.025
Elkhoudary, M. M., Salam, R. A. A., & Hadad, G. M. (2016). Development and optimization of HPLC analysis of Metronizadole, Diloxanide, Spiramycin and Cliniquol in pharmaceutical dosage forms using experimental design. Journal of Chromatographic Science, 54(10), 1-12. https://doi.org/10.1093/chromsci/bmw126
Fonnes, S., Weisser, J. J., Holzknecht, B. J., Arpi, M., & Rosenberg, J. (2020). The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis. Fundamental and Clinical Pharmacology, 34(4), 504-512. https://doi.org/10.1111/fcp.12535
Frasca, D., Dahyot-Fizelier, C., Adier, C., Mimoz, O., Debaene, B., Couet, W., & Marchand, S. (2014). Metronidazole and hydroxymetronidazole central nervous system distribution: 1. Microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury. Antimicrobial Agents and Chemotherapy, 58(2), 1019-1023. https://doi.org/10.1128/AAC.01760-13
García Ortiz, P., Hansen, S. H., Shah, V. P., Menné, T., & Benfeldt, E. (2008). The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. Contact Dermatitis, 59(1), 23-30. https://doi.org/10.1111/j.1600-0536.2008.01348.x
Grotelüschen, R., Heidelmann, L. M., Lütgehetmann, M., Melling, N., Reeh, M., Ghadban, T., Dupree, A., Izbicki, J. R., & Bachmann, K. A. (2020). Antibiotic sensitivity in correlation to the origin of secondary peritonitis: A single center analysis. ScientificReports, 10(1), 1, 18588-9. https://doi.org/10.1038/s41598-020-73356-x
Ilomuanya, M., Uboh, C., Ciallella, J., Li, X., Liu, Y., Ifudu, N., Azubuike, C., & Igwilo, C. (2015). Analysis of metronidazole in equine plasma using liquid chromatography/tandem mass spectrometry and high-resolution accurate mass spectrometry. Rapid Communications in Mass Spectrometry, 29(8), 753-763. https://doi.org/10.1002/rcm.7158
Jeffery, J., Vincent, Z. J., Ayling, R. M., & Lewis, S. J. (2017). Development and validation of a liquid chromatography tandem mass spectrometry assay for the measurement of faecal metronidazole. Clinical Biochemistry, 50(6), 323-330. https://doi.org/10.1016/j.clinbiochem.2016.11.031
Karjagin, J., Pähkla, R., & Starkopf, J. (2004). Perioperative penetration of metronidazole into muscle tissue: A microdialysis study. European Journal of Clinical Pharmacology, 59(11), 809-813. https://doi.org/10.1007/s00228-003-0685-0
Kubíčková, V., & Urbánek, K. (2020). Pharmacokinetics and therapeutic monitoring of piperacillin/tazobactam. KlinMikrobiolInfekc Lek, 26(3), 86-94.
Lanças, F. M. (2012). Efeitos da temperatura em Cromatografia Líquida de Alta Eficiência (HPLC). Scientia Chromatographica, 4(1), 13-19. https://doi.org/10.4322/sc.2012.002
Marchand, S., Chauzy, A., Dahyot-Fizelier, C., & Couet, W. (2016). Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacological Research Elsevier Ltd, 111, 201-207. https://doi.org/10.1016/j.phrs.2016.06.001
Mogollón, N. G. S., de Lima, P. F., Gama, M. R., Furlan, M. F., Braga, S. C. G. N., Prata, P. S., Jardim, I. C. S. F., & Augusto, F. (2014). O estado da arte da cromatografia líquida bidimensional: Conceitos fundamentais, instrumentação e aplicações. Quimica Nova, 37(10), 1680-1691. https://doi.org/10.5935/0100-4042.20140261
Sampaio, C. P. P., Biondo-Simões, M. L. P., Trindade, L. C. T., Olandowski, M., & Matias, J. E. F. (2019). Metronidazole concentration in the bloodstream following its topical application, at different concentration levels, on experimental skin wounds during healing by secondary intention. Acta Cirúrgica Brasileira, 34(1), 1-8. https://doi.org/10.1590/s0102-865020190010000004
Santos, L. A. (2018). A microbiota intestinal E Sua Relação com O Sistema Imunológico. Revista Da Universidade Vale Do Rio Verde, 16(2), 1-9. https://doi.org/10.5892/ruvrd.v16i2.4342
Sekis, I., Ramstead, K., Rishniw, M., Schwark, W. S., McDonough, S. P., Goldstein, R. E., Papich, M., & Simpson, K. W. (2009). Single-dose pharmacokinetics and genotoxicity of metronidazole in cats. Journal of Feline Medicine and Surgery, 11(2), 60-68. https://doi.org/10.1016/j.jfms.2008.06.011
Sørensen, C. G., Karlsson, W. K., Amin, F. M., & Lindelof, M. (2020). Metronidazole-induced encephalopathy: A systematic review. Journal of Neurology, 267(1), 1-13. https://doi.org/10.1007/s00415-018-9147-6
Stancil, S. L., van Haandel, L., Abdel-Rahman, S., & Pearce, R. E. (2018). Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1092(17), 272-278. https://doi.org/10.1016/j.jchromb.2018.06.024
Tsai, T. H., & Chen, Y. F. (2003). Pharmacokinetics of metronidazole in rat blood, brain and bile studied by microdialysis coupled to microbore liquid chromatography. Journal of Chromatography a, 987(2), 277-282. https://doi.org/10.1016/S0021-9673(02)01454-1
US Food and Drug Administration. (2018). Bioanalytical Method Validation: Guidancefor industry. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine. Rockville, MD.
Yoon, J., Kang, S. W., Shim, W. S., Lee, J. K., Jang, D. K., Gu, N., Kim, S. K., Lee, K. T., & Chung, E. K. (2020). Quantification of metronidazole in human bile fluid and plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1138(1), 1, 121959-23. https://doi.org/10.1016/j.jchromb.2019.121959