Current Status on 1,4-Dihydropyridine Derivatives against Human Pathogenic Parasites.
Dihydropyridine
chemotherapy
leishmaniasis
malaria
parasitic diseases
trypanosomiasis
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
06
2022
revised:
18
08
2022
accepted:
20
09
2022
pubmed:
7
11
2022
medline:
17
3
2023
entrez:
6
11
2022
Statut:
ppublish
Résumé
Infections provoked by parasites are among the most prevalent diseases worldwide and generate important health and socioeconomic problems. Despite the enormous amount of work done, the chemotherapy for most of them remains unsolved. Usually, treatments are based on no specific drugs associated, in several cases, with long-term treatments and severe side effects. In addition, drug resistance and different strains' susceptibility are further drawbacks of the existing chemotherapy. Considering that 1,4-dihydropyridines derivatives constitute an important class of compounds for new drug development, we present in this review an in-depth overview of the work done so far on 1,4-dihydropyridines and their antiparasitic activities. The development of new derivatives or the application of known drugs used for other diseases is described in terms of their potential usefulness for drug design.
Identifiants
pubmed: 36336811
pii: CMC-EPUB-127415
doi: 10.2174/0929867330666221104162901
doi:
Substances chimiques
1,4-dihydropyridine
7M8K3P6I89
Dihydropyridines
0
Antiparasitic Agents
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1689-1711Subventions
Organisme : University of Buenos Aires
ID : 20020170100167BA
Organisme : National Research Council of Argentina
ID : PIP 11220170100420CO
Informations de copyright
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