Quercetin: Putative effects on the function of cryopreserved sperms in domestic animals.
cryopreservation
motility
quercetin
sperm
viability
Journal
Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
Titre abrégé: Reprod Domest Anim
Pays: Germany
ID NLM: 9015668
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
24
10
2022
received:
05
09
2022
accepted:
03
11
2022
pubmed:
8
11
2022
medline:
8
2
2023
entrez:
7
11
2022
Statut:
ppublish
Résumé
Quercetin is one of the most used antioxidant flavonoids and largely exists in many fruits and vegetables because of its capability to scavenge the free reactive oxygen species (ROSs) by repressing lipid peroxy radical fusion, metal ion chelating through enzyme inhibition, and adopting the repair mechanisms. It also exhibits various biological actions, including antioxidative, anti-inflammatory and antimicrobial activities. Furthermore, it contributes well to sustaining the endogenous cellular antioxidant defence system. The process of cryopreservation is associated with increased oxidative stress, and some steps are potential sources of ROSs, including the method of semen collection, handling, cryopreservation culture media, and thawing, which result in impaired sperm function. Several antioxidants have been proposed to counteract the harmful impact of ROS during semen cryopreservation. The antioxidant capability of quercetin has been verified in different animal species for providing valuable defence to sperm during the cryopreservation process. The beneficial properties of quercetin on various parameters of fresh and post-thaw sperm in different species are clarified in this review. More in-depth investigations are required to clarify quercetin's mechanism of action in different animal species.
Substances chimiques
Quercetin
9IKM0I5T1E
Antioxidants
0
Cryoprotective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-206Subventions
Organisme : Shaqra University
Informations de copyright
© 2022 Wiley-VCH GmbH.
Références
Abd El-Hack, M. E., Alagawany, M., Arif, M., Emam, M., Saeed, M., Arain, M. A., & Khan, R. U. (2018). The uses of microbial phytase as a feed additive in poultry nutrition-a review. Annals of Animal Science, 18(3), 639-658.
Abd El-Hack, M. E., Alagawany, M., Farag, M. R., Tiwari, R., Karthik, K., & Dhama, K. (2016). Nutritional, healthical and therapeutic efficacy of black cumin (Nigella sativa) in animals, poultry and humans. International Journal of Pharmacology, 12(3), 232-248.
Abd El-Hack, M. E., El-Saadony, M. T., Shehata, A. M., Arif, M., Paswan, V. K., & Elbestawy, A. R. (2021). Approaches to prevent and control campylobacter spp. colonization in broiler chickens: A review. Environmental Science and Pollution Research, 28(5), 4989-5004.
Abd El-Hack, M. E., Shafi, M. E., Alghamdi, W. Y., Abdelnour, S. A., Shehata, A. M., & Ragni, M. (2020). Black soldier fly (Hermetia illucens) meal as a promising feed ingredient for poultry: A comprehensive review. Agriculture, 10(8), 339.
Abdel-Moneim, A. M. E., Shehata, A. M., Alzahrani, S. O., Shafi, M. E., Mesalam, N. M., Taha, A. E., & Abd El-Hack, M. E. (2020). The role of polyphenols in poultry nutrition. Journal of Animal Physiology and Animal Nutrition, 104(6), 1851-1866.
Abdelnour, S. A., Hassan, M. A., El-Ratel, I. T., Essawi, W. M., El-Raghi, A. A., Lu, Y., & Sheiha, A. M. (2022). Effect of addition of L-carnitine to cryopreservation extender on rabbit post-thaw semen parameters, antioxidant capacity, mitochondrial function, apoptosis, and ultrastructure changes. Reproduction in Domestic Animals, 8, 902-911.
Abdelnour, S. A., Swelum, A. A., Sindi, R. A., Barkat, R. A., Khalifa, N. E., Amin, A. A., & Abd El-Hack, M. E. (2022). Responses of sperm mitochondria functionality in animals to thermal stress: The mitigating effects of dietary natural antioxidants. Reproduction in Domestic Animals., 57, 1101-1112. https://doi.org/10.1111/rda.14193
Abdelsattar, M. M., Rashwan, A. K., Younes, H. A., Abdel-Hamid, M., Romeih, E., Mehanni, A. H. E., & Zhang, N. (2022). An updated and comprehensive review on the composition and preservation strategies of bovine colostrum and its contributions to animal health. Animal Feed Science and Technology, 3, 115379.
Ahmed, H., Andrabi, S. M. H., & Jahan, S. (2016). Semen quality parameters as fertility predictors of water buffalo bull spermatozoa during low-breeding season. Theriogenology, 86(6), 1516-1522.
Ahmed, H., Shah, S. A. H., & Jahan, S. (2019). Effect of cryopreservation on CASA characteristics, mitochondrial transmembrane potential, plasma and acrosome integrities, morphology and in vivo fertility of buffalo bull spermatozoa. CryoLetters, 40(3), 173-180.
Aitken, J. B., Naumovski, N., Curry, B., Grupen, C. G., Gibb, Z., & Aitken, R. J. (2015). Characterization of an L-amino acid oxidase in equine spermatozoa. Biology of Reproduction, 92(5), 125 121-113.
Aitken, R. J., Wingate, J. K., De Iuliis, G. N., Koppers, A. J., & McLaughlin, E. A. (2006). Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa. The Journal of Clinical Endocrinology and Metabolism, 91(10), 4154-4163.
Akbarinejad, V., Fathi, R., Shahverdi, A., Esmaeili, V., Rezagholizadeh, A., & Ghaleno, L. R. (2020). The relationship of mitochondrial membrane potential, reactive oxygen species, adenosine triphosphate content, sperm plasma membrane integrity, and kinematic properties in warmblood stallions. Journal of Equine Veterinary Science, 94, 103267.
Aksoy, Y., Aksoy, H., Altinkaynak, K., Aydin, H. R., & Ozkan, A. (2006). Sperm fatty acid composition in subfertile men. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(2), 75-79.
Alagawany, M., Abd El-Hack, M. E., & El-Kholy, M. S. (2016). Productive performance, egg quality, blood constituents, immune functions, and antioxidant parameters in laying hens fed diets with different levels of Yucca schidigera extract. Environmental Science and Pollution Research, 23(7), 6774-6782.
Alagawany, M., Abd El-Hack, M. E., Laudadio, V., & Tufarelli, V. (2014). Effect of low-protein diets with crystalline amino acid supplementation on egg production, blood parameters and nitrogen balance in laying Japanese quails. Avian Biology Research, 7(4), 235-243.
Amann, R. P., & Waberski, D. (2014). Computer-assisted sperm analysis (CASA): Capabilities and potential developments. Theriogenology, 81(1), 5-17.e11-13.
Amaral, A., Lourenco, B., Marques, M., & Ramalho-Santos, J. (2013). Mitochondria functionality and sperm quality. Reproduction, 146(5), R163-R174.
Am-in, N., Kirkwood, R. N., Techakumphu, M., & Tantasuparuk, W. (2011). Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. Theriogenology, 75(5), 897-903.
Appiah, M. O., Li, W., Zhao, J., Liu, H., Dong, Y., Xiang, J., Wang, J., & Lu, W. (2020). Quercetin supplemented casein-based extender improves the post-thaw quality of rooster semen. Cryobiology, 94, 57-65.
Ardeshirnia, R., Zandi, M., & Sanjabi, M. (2017a). The effect of quercetin on fertility of frozen-thawed ram epididymal spermatozoa. South African Journal of Animal Science, 47(2), 237-244.
Aurich, C., Ferrusola, C. O., Vega, F. J. P., Schrammel, N., Morcuende, D., & Aurich, J. (2018). Seasonal changes in the sperm fatty acid composition of Shetland pony stallions. Theriogenology, 107, 149-153.
Avdatek, F., Yeni, D., İnanç, M. E., Çil, B., Tuncer, B., Türkmen, R., & Taşdemir, U. (2018a). Supplementation of quercetin for advanced DNA integrity in bull semen cryopreservation. Andrologia, 50(4), e12975.
Azeem, M., Hanif, M., Mahmood, K., Ameer, N., Chughtai, F. R. S., & Abid, U. (2022). An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: A review. Polymer Bulletin, 5, 1-22.
Banday, M. N., Lone, F. A., Rasool, F., Rashid, M., & Shikari, A. (2017). Use of antioxidants reduce lipid peroxidation and improve quality of crossbred ram sperm during its cryopreservation. Cryobiology, 74, 25-30.
Bang, S., Qamar, A. Y., Tanga, B. M., Fang, X., Seong, G., Nabeel, A. H. T., Yu, I.-J., Saadeldin, I. M., & Cho, J. (2022). Quercetin improves the apoptotic index and oxidative stress in post-thaw dog sperm. Environmental Science and Pollution Research, 29(15), 21925-21934.
Bansal, A. K., & Bilaspuri, G. S. (2010). Impacts of oxidative stress and antioxidants on semen functions. Veterinary Medicine International, 2010, 686137.
Bardestani, A., Ebrahimpour, S., Esmaeili, A., & Esmaeili, A. (2021). Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles. Journal of Nanobiotechnology, 19(1), 1-33.
Beecher, G. R. (2003). Overview of dietary flavonoids: Nomenclature, occurrence and intake. The Journal of Nutrition, 133(10), 3248s-3254s.
Bergsma, A. T., Li, H. T., Eliveld, J., Bulthuis, M. L., Hoek, A., van Goor, H., Bourgonje, A. R., & Cantineau, A. E. (2022). Local and systemic oxidative stress biomarkers for male infertility: The ORION study. Antioxidants, 11(6), 1045.
Brahem, S., Jellad, S., Ibala, S., Saad, A., & Mehdi, M. (2012). DNA fragmentation status in patients with necrozoospermia. Systems Biology in Reproductive Medicine, 58(6), 319-323.
Brito, L. F., Barth, A. D., Bilodeau-Goeseels, S., Panich, P. L., & Kastelic, J. P. (2003). Comparison of methods to evaluate the plasmalemma of bovine sperm and their relationship with In vitro fertilization rate. Theriogenology, 60(8), 1539-1551.
Bucak, M. N., Atessahin, A., Varisli, O., Yuce, A., Tekin, N., & Akcay, A. (2007). The influence of trehalose, taurine, cysteamine and hyaluronan on ram semen microscopic and oxidative stress parameters after freeze-thawing process. Theriogenology, 67(5), 1060-1067.
Bucak, M. N., Keskin, N., Taspinar, M., Coyan, K., Baspinar, N., Cenariu, M. C., Bilgili, A., Ozturk, C., & Kursunlu, A. N. (2013). Raffinose and hypotaurine improve the post-thawed merino ram sperm parameters. Cryobiology, 67(1), 34-39.
Bucak, M. N., Tuncer, P. B., Sarıözkan, S., Başpınar, N., Taşpınar, M., Çoyan, K., Bilgili, A., Akalın, P. P., Büyükleblebici, S., Aydos, S., Ilgaz, S., Sunguroğlu, A., & Öztuna, D. (2010). Effects of antioxidants on post-thawed bovine sperm and oxidative stress parameters: Antioxidants protect DNA integrity against cryodamage. Cryobiology, 61(3), 248-253.
Čabarkapa-Pirković, A., Živković, L., Dekanski, D., Topalović, D., & Spremo-Potparević, B. (2021). Olive leaf, DNA damage and chelation therapy, olives and olive oil in health and disease prevention (pp. 457-469). Elsevier.
Canuto, L. E. F., Segabinazzi, L. G. T. M., De Araújo, E. A. B., Silva, L. F. M. C., De Oliveira, S. N., Dalanezi, F. M., Junior, J. A. D. A., Papa, F. O., & Oba, E. (2022). Effect of quercetin or butylated hydroxytoluene on cooled or frozen-thawed ram sperm quality. Semina: Ciências Agrárias, 43(2), 841-854.
Cassina, A., Silveira, P., Cantu, L., Montes, J. M., Radi, R., & Sapiro, R. (2015). Defective human sperm cells are associated with mitochondrial dysfunction and oxidant Production1. Biology of Reproduction, 93(5), 119.
Chanapiwat, P., & Kaeoket, K. (2020). Cryopreservation of boar semen: Where we are. The Thai Journal of Veterinary Medicine, 50(3), 283-295.
Cooray, A., Kim, J. H., Chae, M. R., Lee, S., & Lee, K. P. (2022). Perspectives on potential fatty acid modulations of motility associated human sperm ion channels. International Journal of Molecular Sciences, 23(7), 3718.
Cordoba, M., Pintos, L. N., & Beconi, M. T. (2007). Heparin and quercitin generate differential metabolic pathways that involve aminotransferases and LDH-X dehydrogenase in cryopreserved bovine spermatozoa. Theriogenology, 67(3), 648-654.
Dawaliby, R., Trubbia, C., Delporte, C., Noyon, C., Ruysschaert, J.-M., Van Antwerpen, P., & Govaerts, C. (2016). Phosphatidylethanolamine is a key regulator of membrane fluidity in eukaryotic cells. The Journal of Biological Chemistry, 291(7), 3658-3667.
Dcunha, R., Hussein, R. S., Ananda, H., Kumari, S., Adiga, S. K., Kannan, N., Zhao, Y., & Kalthur, G. (2022). Current insights and latest updates in sperm motility and associated applications in assisted reproduction. Reproductive Sciences, 29(1), 7-25.
de Oliveira, M. R., Nabavi, S. M., Braidy, N., Setzer, W. N., Ahmed, T., & Nabavi, S. F. (2016). Quercetin and the mitochondria: A mechanistic view. Biotechnology Advances, 34(5), 532-549.
Delmas, D., Jannin, B., Latruffe, N., & Latruffe, P. N. (2005). Resveratrol: Natural properties against atherosclerosis, associated pro-inflammatory effects and aging. Molecular Nutrition & Food Research, 49(5), 377-395.
Desroches, N. R., McNiven, M. A., Foote, K. D., & Richardson, G. F. (2005). The effect of blueberry extracts and quercetin on capacitation status of stored boar sperm. Cell Preservation and Technology, 3(3), 165-168.
Devi, S., Kumar, V., Singh, S. K., Dubey, A. K., & Kim, J.-J. (2021). Flavonoids: Potential candidates for the treatment of neurodegenerative disorders. Biomedicine, 9(2), 99.
Diao, R., Gan, H., Tian, F., Cai, X., Zhen, W., Song, X., & Duan, Y. G. (2019). In vitro antioxidation effect of quercetin on sperm function from the infertile patients with leukocytospermia. American Journal of Reproductive Immunology, 82(3), e13155.
Dias, M. C., Pinto, D. C., & Silva, A. M. (2021). Plant flavonoids: Chemical characteristics and biological activity. Molecules, 26(17), 5377.
Dias, R., Oliveira, H., Fernandes, I., Simal-Gandara, J., & Perez-Gregorio, R. (2021). Recent advances in extracting phenolic compounds from food and their use in disease prevention and as cosmetics. Critical Reviews in Food Science and Nutrition, 61(7), 1130-1151.
Díaz, R., Torres, M., Bravo, S., Sanchez, R., & Sepúlveda, N. (2016). Determination of fatty acid profile in ram spermatozoa and seminal plasma. Andrologia, 48(6), 723-726.
Diniz, W., Modi, L., Chaudhari, N., Chaudhary, S., Pandor, M., Kumar, D. 2021. Antioxidant effect of quercetin in tris egg yolk citrate extender on Surti buck semen preserved at refrigerated temperature. International Journal of Livestock Research, 11(1), 87-92.
Diniz, W. V., Modi, L. C., Chaudhari, N., Dangar, N., & Sharma, H. (2022). International journal of current microbiology and applied sciences. International Journal of Current Microbiology and Applied Sciences, 11(3), 32-37.
Dumanović, J., Nepovimova, E., Natić, M., Kuča, K., & Jaćević, V. (2021). The significance of reactive oxygen species and antioxidant defense system in plants: A concise overview. Frontiers in Plant Science, 11, 552969.
Durairajanayagam, D., Singh, D., Agarwal, A., & Henkel, R. (2021). Causes and consequences of sperm mitochondrial dysfunction. Andrologia, 53(1), e13666.
Dutta, S., Majzoub, A., & Agarwal, A. (2019). Oxidative stress and sperm function: A systematic review on evaluation and management. Arab Journal of Urology, 17(2), 87-97.
El-Khawagah, A. R., Kandiel, M. M., & Samir, H. (2020). Effect of quercetin supplementation in extender on sperm kinematics, extracellular enzymes release, and oxidative stress of Egyptian buffalo bulls frozen-thawed semen. Frontiers in Veterinary Science, 7, 604460.
Engel, K. M., Dzyuba, V., Ninhaus-Silveira, A., Veríssimo-Silveira, R., Dannenberger, D., Schiller, J., Steinbach, C., & Dzyuba, B. (2020). Sperm lipid composition in early diverged fish species: Internal vs. external mode of fertilization. Biomolecules, 10(2), 172.
Estrada, E., Rivera Del Alamo, M. M., Rodriguez-Gil, J. E., & Yeste, M. (2017). The addition of reduced glutathione to cryopreservation media induces changes in the structure of motile subpopulations of frozen-thawed boar sperm. Cryobiology, 78, 56-64.
Figueroa, E., Farias, J. G., Lee-Estevez, M., Valdebenito, I., Risopatrón, J., Magnotti, C., Romero, J., Watanabe, I., & Oliveira, R. P. S. (2018). Sperm cryopreservation with supplementation of α-tocopherol and ascorbic acid in freezing media increase sperm function and fertility rate in Atlantic salmon (Salmo salar). Aquaculture, 493, 1-8.
Froman, D. P., & Feltmann, A. J. (2010). A new approach to sperm preservation based on bioenergetic theory1. Journal of Animal Science, 88(4), 1314-1320.
Gervasi, M. G., & Visconti, P. E. (2017). Molecular changes and signaling events occurring in spermatozoa during epididymal maturation. Andrology, 5(2), 204-218.
Gibb, Z., Butler, T. J., Morris, L. H., Maxwell, W. M., & Grupen, C. G. (2013). Quercetin improves the postthaw characteristics of cryopreserved sex-sorted and nonsorted stallion sperm. Theriogenology, 79(6), 1001-1009.
Gironde, C., Rigal, M., Dufour, C., & Furger, C. (2020). AOP1, a new live cell assay for the direct and quantitative measure of intracellular antioxidant effects. Antioxidants, 9(6), 471.
Gomez-Torres, M. J., Medrano, L., Romero, A., Fernandez-Colom, P. J., & Aizpurua, J. (2017). Effectiveness of human spermatozoa biomarkers as indicators of structural damage during cryopreservation. Cryobiology, 78, 90-94.
Grötter, L. G., Cattaneo, L., Marini, P. E., Kjelland, M. E., & Ferré, L. B. (2019). Recent advances in bovine sperm cryopreservation techniques with a focus on sperm post-thaw quality optimization. Reproduction in Domestic Animals, 54(4), 655-665.
Gürler, H., Malama, E., Heppelmann, M., Calisici, O., Leiding, C., Kastelic, J. P., & Bollwein, H. (2016). Effects of cryopreservation on sperm viability, synthesis of reactive oxygen species, and DNA damage of bovine sperm. Theriogenology, 86(2), 562-571.
Ha, A. T., Rahmawati, L., You, L., Hossain, M. A., Kim, J.-H., & Cho, J. Y. (2021). Anti-inflammatory, antioxidant, moisturizing, and antimelanogenesis effects of quercetin 3-O-β-D-glucuronide in human keratinocytes and melanoma cells via activation of NF-κB and AP-1 pathways. International Journal of Molecular Sciences, 23(1), 433.
Hagen, D. R., Gilkey, A. L., & Foote, R. H. (2010). Spermatozoal velocity and motility and its relationship to fertility in the rabbit inseminated with low sperm numbers. World Rabbit Science, 10(4), 6.
Hassan, E., El-Neweshy, M., Hassan, M., & Noreldin, A. (2019). Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved. Life Sciences, 230, 132-140.
Havsteen, B. H. (2002). The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics, 96(2-3), 67-202.
Henkel, R., Maaß, G., Bödeker, R.-H., Scheibelhut, C., Stalf, T., Mehnert, C., Schuppe, H.-C., Jung, A., & Schill, W.-B. (2005). Sperm function and assisted reproduction technology. Reproductive Medicine and Biology, 4(1), 7-30.
Hezavehei, M., Sharafi, M., Kouchesfahani, H. M., Henkel, R., Agarwal, A., Esmaeili, V., & Shahverdi, A. (2018). Sperm cryopreservation: A review on current molecular cryobiology and advanced approaches. Reproductive Biomedicine Online, 37(3), 327-339.
Hirose, M., Honda, A., Fulka, H., Tamura-Nakano, M., Matoba, S., Tomishima, T., Mochida, K., Hasegawa, A., Nagashima, K., & Inoue, K. (2020). Acrosin is essential for sperm penetration through the zona pellucida in hamsters. Proceedings of the National Academy of Sciences, 117(5), 2513-2518.
Hou, S., Song, Y., Sun, D., Zhu, S., & Wang, Z. (2021). Xanthohumol-induced rat glioma C6 cells death by triggering mitochondrial stress. International Journal of Molecular Sciences, 22(9), 4506.
Jiménez-Aguilar, E., Quezada-Casasola, A., Prieto-Caraveo, M., Orozco-Lucero, E., Itzá-Ortiz, M., & Carrera-Chávez, J. (2021). Evaluation of the quercetin and vitamin E addition to the cryopreservation medium of sheep semen on in vivo fertility. Abanico veterinario, 11, 1-14.
Johinke, D., de Graaf, S. P., & Bathgate, R. (2014). Quercetin reduces the In vitro production of H2O2 during chilled storage of rabbit spermatozoa. Animal Reproduction Science, 151(3), 208-219.
Johinke, D., de Graaf, S. P., & Bathgate, R. (2015). The effect of sperm concentration and storage vessel on quercetin-supplemented rabbit semen during chilled storage. Reproduction in Domestic Animals, 50(4), 567-573.
Jorge Filho, S., Corcini, C. D., Santos, F. C. C. D., Anciuti, A. N., Gatti, N. L. S., Anastácio, E., Mielke, R., Nogueira, C. E. W., Curcio, B. D. R., & Junior, A. S. V. (2017). Quercetin in Equine Frozen Semen. Cryo Letters, 38(4), 299-304.
Jung, M., Rudiger, K., & Schulze, M. (2015). In vitro measures for assessing boar semen fertility. Reproduction in Domestic Animals, 50(Suppl 2), 20-24.
Kaewmala, K., Uddin, M., Cinar, M., Große-Brinkhaus, C., Jonas, E., Tesfaye, D., Phatsara, C., Tholen, E., Looft, C., & Schellander, K. (2011). Investigation into association and expression of PLCz and COX-2 as candidate genes for boar sperm quality and fertility. Reproduction in Domestic Animals, 47, 213-223.
Karakus, F. N., Kuran, S. B., & Solakoglu, S. (2021). Effect of curcumin on sperm parameters after the cryopreservation. European Journal of Obstetrics & Gynecology and Reproductive Biology, 267, 161-166.
Keles, E., Malama, E., Bozukova, S., Siuda, M., Wyck, S., Witschi, U., Bauersachs, S., & Bollwein, H. (2021). The micro-RNA content of unsorted cryopreserved bovine sperm and its relation to the fertility of sperm after sex-sorting. BMC Genomics, 22(1), 1-19.
Khafaga, A. F., Abd El-Hack, M. E., Taha, A. E., Elnesr, S. S., & Alagawany, M. (2019). The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: A review. Environmental Science and Pollution Research, 26(5), 4588-4604.
Khafaga, A. F., & Bayad, A. E. (2016). Impact of Ginkgo biloba extract on reproductive toxicity induced by single or repeated injection of cisplatin in adult male rats. International Journal of Pharmacology, 12(4), 340-350.
Khan, I. M., Cao, Z., Liu, H., Khan, A., Rahman, S. U., Khan, M. Z., Sathanawongs, A., & Zhang, Y. (2021). Impact of cryopreservation on spermatozoa freeze-thawed traits and relevance omics to assess sperm cryo-tolerance in farm animals. Frontiers in Veterinary Science, 8, 609180.
Khoddami, A., Wilkes, M. A., & Roberts, T. H. (2013). Techniques for analysis of plant phenolic compounds. Molecules, 18(2), 2328-2375.
Khumran, A. M., Yimer, N., Rosnina, Y., Ariff, M. O., Wahid, H., Kaka, A., Ebrahimi, M., & Sarsaifi, K. (2015). Butylated hydroxytoluene can reduce oxidative stress and improve quality of frozen-thawed bull semen processed in lecithin and egg yolk based extenders. Animal Reproduction Science, 163, 128-134.
Kim, T. H., Yuh, S., Park, C., Cheong, H. T., Kim, J. T., Park, C. K., & Yang, B. K. (2014). Effects of quercetin and genistein on boar sperm characteristics and porcine IVF Embyo development. Journal of Embryo Transfer, 29, 141-148.
Kültz, D. (2020). Evolution of cellular stress response mechanisms. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, 333(6), 359-378.
Kumar, P., Chand, S., & Maurya, P. K. (2016). Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: Correlation with ATPase's. Archives of Physiology and Biochemistry, 122(3), 141-147.
Kumar, P., Srivastava, N., Pande, M., Prasad, J. K., & Sirohi, A. S. (2017). Evaluating sperm cell viability and membrane integrity. In N. Srivastava & M. Pande (Eds.), Protocols in semen biology (comparing assays) (pp. 57-71). Springer Singapore.
Kumaresan, A., Das Gupta, M., Datta, T. K., & Morrell, J. M. (2020). Sperm DNA integrity and male fertility in farm animals: A review. Frontiers in Veterinary Science, 7, 321.
Le, M. T., Nguyen, T. T. T., Nguyen, T. T., Nguyen, T. T. A., Nguyen, V. Q. H., & Cao, N. T. (2019). Cryopreservation of human spermatozoa by vitrification versus conventional rapid freezing: Effects on motility, viability, morphology and cellular defects. European Journal of Obstetrics & Gynecology and Reproductive Biology, 234, 14-20.
Leemans, B., Stout, T. A. E., De Schauwer, C., Heras, S., Nelis, H., Hoogewijs, M., Van Soom, A., & Gadella, B. M. (2019). Update on mammalian sperm capacitation: How much does the horse differ from other species? Reproduction, 157, R181-R197.
Legault, Y., Bouthillier, M., Bleau, G., Chapdelaine, A., & Roberts, K. (1979). The sterol and sterol sulfate content of the male hamster reproductive tract. Biology of Reproduction, 20(5), 1213-1219.
Li, M.-W., & Lloyd, K. (2020). DNA fragmentation index (DFI) as a measure of sperm quality and fertility in mice. Scientific Reports, 10(1), 1-11.
Liu, Z., Zhang, L. P., Ma, H. J., Wang, C., Li, M., & Wang, Q. S. (2005). Resveratrol reduces intracellular free calcium concentration in rat ventricular myocytes. Sheng li xue bao: [Acta Physiologica Sinica], 57(5), 599-604.
Longobardi, V., Zullo, G., Cotticelli, A., Salzano, A., Albero, G., Navas, L., Rufrano, D., Claps, S., & Neglia, G. (2020). Crocin improves the quality of cryopreserved goat semen in different breeds. Animals, 10(6), 1101.
Lucio, C. D. F., Brito, M. M., Angrimani, D. D. S. R., Belaz, K. R. A., Morais, D., Zampieri, D., Losano, J. D. D. A., Assumpção, M., Nichi, M., & Eberlin, M. N. (2017). Lipid composition of the canine sperm plasma membrane as markers of sperm motility. Reproduction in Domestic Animals, 52, 208-213.
Mandal, R., Badyakar, D., & Chakrabarty, J. (2014). Role of membrane lipid fatty acids in sperm cryopreservation. Advances in Andrology, 2014, 9.
Masoudi, R., Sharafi, M., Shahneh, A. Z., & Khodaei-Motlagh, M. (2019). Effects of reduced glutathione on the quality of rooster sperm during cryopreservation. Theriogenology, 128, 149-155.
Matabane, M., Thomas, R., Netshirovha, T., Tsatsimpe, M., Ng'ambi, J., Nephawe, K., & Nedambale, T. (2017a). Relationship between sperm plasma membrane integrity and morphology and fertility following artificial insemination. South African Journal of Animal Science, 47(1), 102-106.
McNiven, M. A., & Richardson, G. F. (2002). Chilled storage of stallion semen using perfluorochemicals and antioxidants. Cell Preservation and Technology, 1(3), 165-174.
McNiven, M. A., & Richardson, G. F. (2006). Effect of quercetin on capacitation status and lipid peroxidation of stallion spermatozoa. Cell Preservation and Technology, 4(3), 169-177.
Mehana, E. S. E., Khafaga, A. F., Elblehi, S. S., Abd El-Hack, M. E., Naiel, M. A., Bin-Jumah, M., & Allam, A. A. (2020). Biomonitoring of heavy metal pollution using acanthocephalans parasite in ecosystem: An updated overview. Animals, 10(5), 811.
Miller, R. R., Jr., Cornett, C. L., Waterhouse, K. E., & Farstad, W. (2005). Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation. Cryobiology, 51(1), 66-75.
Miller, R. R., Sheffer, C. J., Cornett, C. L., McClean, R., MacCallum, C., & Johnston, S. D. (2004). Sperm membrane fatty acid composition in the eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. Cryobiology, 49(2), 137-148.
Mondal, T., Pal, S., & Dey, S. K. (2017). Quercetin mediated inhibition of hydrogen peroxide-induced genomic DNA damage and toxicity. Journal of Biologically Active Products from Nature, 7(3), 200-213.
Montané, X., Kowalczyk, O., Reig-Vano, B., Bajek, A., Roszkowski, K., Tomczyk, R., Pawliszak, W., Giamberini, M., Mocek-Płóciniak, A., & Tylkowski, B. (2020). Current perspectives of the applications of polyphenols and flavonoids in cancer therapy. Molecules, 25(15), 3342.
Moretti, E., Mazzi, L., Terzuoli, G., Bonechi, C., Iacoponi, F., Martini, S., Rossi, C., & Collodel, G. (2012). Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm. Reproductive toxicology (Elmsford, N.Y.), 34(4), 651-657.
Mostafa, T., Rashed, L., Nabil, N., & Amin, R. (2014). Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele. Urology, 84, 590-595.
Mukhopadhyay, C. S., Gupta, A. K., Yadav, B. R., Chauhan, I. S., Gupta, A., Mohanty, T. K., & Raina, V. S. (2011). Effect of cryopreservation on sperm chromatin integrity and fertilizing potential in bovine semen. Livestock Science, 136(2), 114-121.
Naresh, S., & Atreja, S. K. (2015). The protein tyrosine phosphorylation during In vitro capacitation and cryopreservation of mammalian spermatozoa. Cryobiology, 70(3), 211-216.
Nass-Arden, L., & Breitbart, H. (1990). Modulation of mammalian sperm motility by quercetin. Molecular Reproduction and Development, 25(4), 369-373.
Nile, S. H., Nile, A. S., Keum, Y. S., & Sharma, K. (2017). Utilization of quercetin and quercetin glycosides from onion (Allium cepa L.) solid waste as an antioxidant, urease and xanthine oxidase inhibitors. Food Chemistry, 235, 119-126.
Nowicka-Bauer, K., & Nixon, B. (2020). Molecular changes induced by oxidative stress that impair human sperm motility. Antioxidants, 9(2), 134.
Olson, S. D., Fauci, L. J., & Suarez, S. S. (2011). Mathematical modeling of calcium signaling during sperm hyperactivation. Molecular Human Reproduction, 17(8), 500-510.
Oresti, G. M., Peñalva, D. A., Luquez, J. M., Antollini, S. S., & Aveldaño, M. I. (2015). Lipid Biochemical and biophysical changes in rat spermatozoa during isolation and functional activation In vitro. Biology of Reproduction, 93(6), 140.
Osawe, S., & Farombi, E. (2018). Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. Andrologia, 50(5), e12981.
Partyka, A., & Niżański, W. (2021). Supplementation of avian semen extenders with antioxidants to improve semen quality-Is it an effective strategy? Antioxidants, 10(12), 1927.
Peris-Frau, P., Soler, A. J., Iniesta-Cuerda, M., Martín-Maestro, A., Sánchez-Ajofrín, I., Medina-Chávez, D. A., Fernández-Santos, M. R., García-Álvarez, O., Maroto-Morales, A., & Montoro, V. (2020). Sperm cryodamage in ruminants: Understanding the molecular changes induced by the cryopreservation process to optimize sperm quality. International Journal of Molecular Sciences, 21(8), 2781.
Perrotta, I., Santoro, M., Guido, C., Avena, P., Tripepi, S., De Amicis, F., Gervasi, M. C., & Aquila, S. (2012). Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: A potential molecular marker for diagnosing male infertility disorders. Journal of Anatomy, 221, 209-220.
Perumal, P., Vikram, R., Khate, K., Vupru, K., Saddamhusen, M., & Khan, M. (2021). Glutathione in semen extender modulates post thaw semen quality profiles, and antioxidant and oxidative stress profiles in mithun. The Indian Journal of Animal Sciences, 91(12), 1018-1026.
Piomboni, P., Focarelli, R., Stendardi, A., Ferramosca, A., & Zara, V. (2012). The role of mitochondria in energy production for human sperm motility. International Journal of Andrology, 35(2), 109-124.
Puga Molina, L. C., Luque, G. M., Balestrini, P. A., Marin Briggiler, C. I., Romarowski, A., & Buffone, M. G. (2018). Molecular basis of human sperm capacitation. Frontiers in Cell and Development Biology, 6, 72.
Puigmulé, M., Fàbrega, A., Yeste, M., Bonet, S., & Pinart, E. (2011). Study of the proacrosin-acrosin system in epididymal, ejaculated and In vitro capacitated boar spermatozoa. Reproduction, Fertility, and Development, 23(7), 837-845.
Rahman, M. B., Schellander, K., Luceño, N. L., & Van Soom, A. (2018). Heat stress responses in spermatozoa: Mechanisms and consequences for cattle fertility. Theriogenology, 113, 102-112.
Rakha, B. A., Qurrat-ul, A., Ansari, M. S., Akhter, S., Akhter, A., Awan, M. A., & Santiago-Moreno, J. (2020). Effect of quercetin on oxidative stress, mitochondrial activity, and quality of Indian red jungle fowl (Gallus gallus murghi) sperm. Biopreservation and Biobanking, 18(4), 311-320.
Reddy, V. S., Yadav, B., Yadav, C. L., Anand, M., Swain, D. K., Kumar, D., Kritania, D., Madan, A. K., Kumar, J., & Yadav, S. (2018). Effect of sericin supplementation on heat shock protein 70 (HSP70) expression, redox status and post thaw semen quality in goat. Cryobiology, 84, 33-39.
Ren, F., Feng, T., Dai, G., Wang, Y., Zhu, H., & Hu, J. (2018). Lycopene and alpha-lipoic acid improve semen antioxidant enzymes activity and cashmere goat sperm function after cryopreservation. Cryobiology, 84, 27-32.
Ribas-Maynou, J., Mateo-Otero, Y., Delgado-Bermudez, A., Bucci, D., Tamanini, C., Yeste, M., & Barranco, I. (2021). Role of exogenous antioxidants on the performance and function of pig sperm after preservation in liquid and frozen states: A systematic review. Theriogenology, 173, 279-294.
Ridley, J. W. (2018). Semen evaluation, fundamentals of the study of urine and body fluids (pp. 277-300). Springer.
Riesco, M. F., Alvarez, M., Anel-Lopez, L., Neila-Montero, M., Palacin-Martinez, C., Montes-Garrido, R., Boixo, J. C., de Paz, P., & Anel, L. (2021). Multiparametric study of antioxidant effect on ram sperm cryopreservation-From field trials to research bench. Animals, 11(2), 283.
Roldan, E., & Fleming, A. (1989). Is a Ca2+-ATPase involved in Ca2+ regulation during capacitation and the acrosome reaction of Guinea-pig spermatozoa? Reproduction, 85(1), 297-308.
Rud, M., Shepitko, V., Stetsuk, Y. V., & Akimov, O. Y. (2022). The effect of quercetin on morphological and BIOCHEMICAL changes IN rat liver under 270TH day CENTRAL deprivation of luteinizing hormone synthesis. The Medical and Ecological Problems, 26(1-2), 22-25.
Saeed, M., Abd El-Hack, M. E., Alagawany, M., Arain, M. A., Arif, M., Mirza, M. A., & Dhama, K. (2017). Chicory (Cichorium intybus) herb: Chemical composition, pharmacology, nutritional and healthical applications. International Journal of Pharmacology, 13(4), 351-360.
Saeed, M., Yatao, X., Hassan, F. U., Arain, M. A., Abd El-Hack, M. E., Noreldin, A. E., & Sun, C. (2018). Influence of graded levels of l-theanine dietary supplementation on growth performance, carcass traits, meat quality, organs histomorphometry, blood chemistry and immune response of broiler chickens. International Journal of Molecular Sciences, 19(2), 462.
Saleh, A., Kashir, J., Thanassoulas, A., Safieh-Garabedian, B., Lai, F. A., & Nomikos, M. (2020). Essential role of sperm-specific PLC-zeta in egg activation and male factor infertility: An update. Frontiers in Cell and Development Biology, 8, 28.
Samplaski, M. K., Dimitromanolakis, A., Lo, K. C., Grober, E. D., Mullen, B., Garbens, A., & Jarvi, K. A. (2015). The relationship between sperm viability and DNA fragmentation rates. Reproductive biology and endocrinology: RB&E, 13, 42.
Santiani Acosta, A., Evangelista Vargas, S., Valdivia Cuya, M., Risopatrón González, J., & Sánchez Gutiérrez, R. (2013). Effect of the addition of two superoxide dismutase analogues (tempo and tempol) to alpaca semen extender for cryopreservation. Theriogenology, 79(5), 842-846.
Sarıözkan, S., Bucak, M. N., Tuncer, P. B., Büyükleblebici, S., & Cantürk, F. (2014). Influence of various antioxidants added to TCM-199 on post-thaw bovine sperm parameters, DNA integrity, and fertilizing ability. Cryobiology, 68(1), 129-133.
Sarlos, P., Molnar, A., Kokai, M., Gabor, G., & Ratky, J. (2002). Comparative evaluation of the effect of antioxidants in the conservation of ram semen. Acta Veterinaria Hungarica, 50(2), 235-245.
Seifi-Jamadi, A., Ahmad, E., Ansari, M., & Kohram, H. (2017). Antioxidant effect of quercetin in an extender containing DMA or glycerol on freezing capacity of goat semen. Cryobiology, 75, 15-20.
Seifi-Jamadi, A., Kohram, H., Zare Shahneh, A., Ansari, M., & Macías-García, B. (2016). Quercetin ameliorate motility in frozen-thawed Turkmen stallions sperm. Journal of Equine Veterinary Science, 45, 73-77.
Sengupta, T., Ghoshal, S., Dungdung, S. R., Majumder, G. C., & Sen, P. C. (2008). Structural and functional characterization and physiological significance of a stimulator protein of Mg2+−independent Ca2+-ATPase isolated from goat spermatozoa. Molecular and Cellular Biochemistry, 311(1), 93-103.
Serafini, S., & O'Flaherty, C. (2021). Redox regulation to modulate phosphorylation events in human spermatozoa. Antioxidants & Redox Signaling, 37(7-9), 437-450.
Shah, P. M., Priya, V. V., & Gayathri, R. (2016). Quercetin-a flavonoid: A systematic review. Journal of Pharmaceutical Sciences and Research, 8(8), 878.
Shi, X., Hu, H., Ji, G., Zhang, J., Liu, R., Zhang, H., & Li, M. (2018). Protective effect of sucrose and antioxidants on cryopreservation of sperm motility and DNA integrity in C57BL/6 mice. Biopreservation and Biobanking, 16(6), 444-450.
Siari, S., Mehri, M., & Sharafi, M. (2021). Supplementation of Beltsville extender with quercetin improves the quality of frozen-thawed rooster semen. British Poultry Science, 63, 252-260. https://doi.org/10.1080/00071668.2021.1955331
Sielhorst, J., Hagen, C., Behrendt, D., Schuette, B., Burger, D., Martinsson, G., & Sieme, H. (2016). Effect of multiple freezing of stallion semen on sperm quality and fertility. Journal of Equine Veterinary Science, 40, 56-61.
Silva, E. C., Cajueiro, J. F., Silva, S. V., Soares, P. C., & Guerra, M. M. (2012). Effect of antioxidants resveratrol and quercetin on In vitro evaluation of frozen ram sperm. Theriogenology, 77(8), 1722-1726.
Silva, E. C. B., Arruda, L. C. P., Silva, S. V., Souza, H. M., & Guerra, M. M. P. (2016). High resveratrol or quercetin concentrations reduce the oscillation index of frozen goat semen. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 68, 1237-1243.
Singh, A.-K., Patel, P. K., Choudhary, K., Joshi, J., Yadav, D., & Jin, J.-O. (2020). Quercetin and coumarin inhibit dipeptidyl peptidase-IV and exhibits antioxidant properties: in silico, In vitro, ex vivo. Biomolecules, 10(2), 207.
Song, X., Wang, Y., & Gao, L. (2020). Mechanism of antioxidant properties of quercetin and quercetin-DNA complex. Journal of Molecular Modeling, 26(6), 1-8.
Sorelle, D. N., Ferdinand, N., & Vemo Bertin Narcisse, T. (2019). Medicinal plants and female reproduction disorders due to oxidative stress. Archives of Veterinary Science and Medicine, 2(4), 58-73.
Squeff Filho, J. (2018). Adição de quercetina e progesterona ao sêmen equino. Universidade Federal de Pelotas.
Srivastava, N. S., & Srivastava, R. A. K. (2019). Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells. Phytomedicine, 52, 117-128.
Srivastava, S., Somasagara, R. R., Hegde, M., Nishana, M., Tadi, S. K., Srivastava, M., Choudhary, B., & Raghavan, S. C. (2016). Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis. Scientific Reports, 6, 24049.
Strasser, M. O., & Dupree, J. M. (2020). Care delivery for male infertility: The present and future. Urologic Clinics, 47(2), 193-204.
Stromsnes, K., Mas-Bargues, C., Gambini, J., & Gimeno-Mallench, L. (2020). Protective effects of polyphenols present in mediterranean diet on endothelial dysfunction. Oxidative Medicine and Cellular Longevity, 2020, 1-10.
Tanaka, S., Trakooncharoenvit, A., Nishikawa, M., Ikushiro, S., & Hara, H. (2019). Comprehensive analyses of quercetin conjugates by LC/MS/MS revealed that isorhamnetin-7-O-glucuronide-4′-O-sulfate is a major metabolite in plasma of rats fed with quercetin glucosides. Journal of Agricultural and Food Chemistry, 67(15), 4240-4249.
Tang, S., Davoudi, Z., Wang, G., Xu, Z., Rehman, T., Prominski, A., Tian, B., Bratlie, K. M., Peng, H., & Wang, Q. (2021). Soft materials as biological and artificial membranes. Chemical Society Reviews, 50, 12679-12701.
Tasdemir, U., Buyukleblebici, S., Tuncer, P. B., Coskun, E., Ozgurtas, T., Aydin, F. N., Buyukleblebici, O., & Gurcan, I. S. (2013). Effects of various cryoprotectants on bull sperm quality, DNA integrity and oxidative stress parameters. Cryobiology, 66(1), 38-42.
Tavilani, H., Doosti, M., Nourmohammadi, I., Mahjub, H., Vaisiraygani, A., Salimi, S., & Hosseinipanah, S. M. (2007). Lipid composition of spermatozoa in normozoospermic and asthenozoospermic males. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77(1), 45-50.
Tian, C., Liu, X., Chang, Y., Wang, R., Lv, T., Cui, C., & Liu, M. (2021). Investigation of the anti-inflammatory and antioxidant activities of luteolin, kaempferol, apigenin and quercetin. South African Journal of Botany, 137, 257-264.
Turrens, J. F. (2003). Mitochondrial formation of reactive oxygen species. The Journal of Physiology, 552(2), 335-344.
Tvrdá, E., Debacker, M., Ďuračka, M., Kováč, J., & Bučko, O. (2020). Quercetin and naringenin provide functional and antioxidant protection to stored boar semen. Animals, 10(10), 1930.
Tvrdá, E., Tušimová, E., Kováčik, A., Paál, D., Libová, Ľ., & Lukáč, N. (2016). Protective effects of quercetin on selected oxidative biomarkers in bovine spermatozoa subjected to ferrous ascorbate. Reproduction in Domestic Animals, 51(4), 524-537.
Upadhyay, V. R., Ramesh, V., Dewry, R. K., Kumar, G., Raval, K., & Patoliya, P. (2021). Implications of cryopreservation on structural and functional attributes of bovine spermatozoa: An overview. Andrologia, 53(8), e14154.
Upadhyay, V. R., Ramesh, V., Dewry, R. K., Yadav, D. K., & Ponraj, P. (2022). Bimodal interplay of reactive oxygen and nitrogen species in physiology and pathophysiology of bovine sperm function. Theriogenology, 187, 82-94.
Vardiyan, R., Ezati, D., Anvari, M., Ghasemi, N., & Talebi, A. (2020). Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax. Clinical and Experimental Reproductive Medicine, 47, 155-160.
Varo-Ghiuru, F., Miclea, I., Hettig, A., Ladosi, I., Miclea, V., Egerszegi, I., & Zahan, M. (2015). Lutein, Trolox, ascorbic acid and combination of Trolox with ascorbic acid can improve boar semen quality during cryopreservation. Cryo Letters, 36(1), 1-7.
Walczak-Jedrzejowska, R., Wolski, J. K., & Slowikowska-Hilczer, J. (2013). The role of oxidative stress and antioxidants in male fertility. Central European Journal of Urology, 66(1), 60-67.
Wassall, S. R., & Stillwell, W. (2009). Polyunsaturated fatty acid-cholesterol interactions: Domain formation in membranes. Biochimica et Biophysica Acta, 1788(1), 24-32.
Waterhouse, K. E., Hofmo, P. O., Tverdal, A., & Miller, R. R., Jr. (2006). Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. Reproduction, 131(5), 887-894.
Winn, E., & Whitaker, B. D. (2018). 489 quercetin supplementation during boar semen thawing and incubation improves sperm characteristics. Journal of Animal Science, 96(suppl_2), 261-262.
Xu, F., Guo, G., Zhu, W., & Fan, L. (2018a). Human sperm acrosome function assays are predictive of fertilization rate In vitro: A retrospective cohort study and meta-analysis. Reproductive Biology and Endocrinology, 16(1), 1-29.
Xu, F., Guo, G., Zhu, W., & Fan, L. (2018b). Human sperm acrosome function assays are predictive of fertilization rate In vitro: A retrospective cohort study and meta-analysis. Reproductive Biology and Endocrinology: RB&E, 16(1), 81.
Yeste, M., Bonet, S., Rodríguez-Gil, J. E., & Rivera Del Álamo, M. M. (2018). Evaluation of sperm motility with CASA-mot: Which factors may influence our measurements? Reproduction, Fertility, and Development, 30(6), 789-798.
Yoshimoto, H., Takeo, T., & Nakagata, N. (2017a). Dimethyl sulfoxide and quercetin prolong the survival, motility, and fertility of cold-stored mouse sperm for 10 days. Biology of Reproduction, 97(6), 883-891.
Zaplatic, E., Bule, M., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019). Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease. Life Sciences, 224, 109-119.