[Pre-clinical validation of a turbine-based ventilator for invasive ventilation-The ACUTE-19 ventilator].
Validación preclínica de un respirador de turbina para la ventilación invasiva: el respirador ACUTE-19.
Bench study
COVID-19
Mechanical ventilation
Medical capacity surge
SARS-CoV-2
Ventilator performance
Journal
Revista espanola de anestesiologia y reanimacion
ISSN: 2340-3284
Titre abrégé: Rev Esp Anestesiol Reanim
Pays: Spain
ID NLM: 0134516
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
14
12
2020
accepted:
07
09
2021
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
ppublish
Résumé
The severe acute respiratory syndrome-coronavirus 2 pandemic pressure on healthcare systems can exhaust ventilator resources, especially where resources are restricted. Our objective was a rapid preclinical evaluation of a newly developed turbine-based ventilator, named the ACUTE-19, for invasive ventilation. Validation consisted of (a) testing tidal volume delivery in 11 simulated models, with various resistances and compliances; (b) comparison with a commercial ventilator (VIVO-50) adapting the United Kingdom Medicines and Healthcare products Regulatory Agency-recommendations for rapidly manufactured ventilators; and (c) Differences in tidal volume in the simulated models were marginally different (largest difference 33 ml [95% CI 31 to 36]; The ACUTE-19 performed accurately in simulated and animal models yielding a comparable performance with a VIVO-50 commercial device. The ACUTE-19 can provide the basis for the development of a future affordable commercial ventilator.
Sections du résumé
Background
UNASSIGNED
The severe acute respiratory syndrome-coronavirus 2 pandemic pressure on healthcare systems can exhaust ventilator resources, especially where resources are restricted. Our objective was a rapid preclinical evaluation of a newly developed turbine-based ventilator, named the ACUTE-19, for invasive ventilation.
Methods
UNASSIGNED
Validation consisted of (a) testing tidal volume delivery in 11 simulated models, with various resistances and compliances; (b) comparison with a commercial ventilator (VIVO-50) adapting the United Kingdom Medicines and Healthcare products Regulatory Agency-recommendations for rapidly manufactured ventilators; and (c)
Results
UNASSIGNED
Differences in tidal volume in the simulated models were marginally different (largest difference 33 ml [95% CI 31 to 36];
Conclusions
UNASSIGNED
The ACUTE-19 performed accurately in simulated and animal models yielding a comparable performance with a VIVO-50 commercial device. The ACUTE-19 can provide the basis for the development of a future affordable commercial ventilator.
Identifiants
pubmed: 36337377
doi: 10.1016/j.redar.2021.09.008
pii: S0034-9356(21)00267-X
pmc: PMC9617684
doi:
Types de publication
English Abstract
Journal Article
Langues
spa
Pagination
544-555Informations de copyright
© 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved.
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