Negatively-charged supported lipid bilayers regulate neuronal adhesion and outgrowth.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
24 Oct 2022
24 Oct 2022
Historique:
received:
17
08
2022
accepted:
14
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
epublish
Résumé
One of the main challenges in neuroelectronics is the implementation of electronic platforms able to secure a tight coupling with neuronal cells and achieve an optimal signal to noise ratio during stimulation/recording of electrophysiological activity. In this context, supported lipid bilayers (SLBs), recapitulating the structure and the dynamicity of the biological plasma membrane, offer a promising biomimetic approach to trick cells to recognize a device as part of their native environment, tightening the cell-chip coupling. Among possible functionalization strategies used to improve cell adhesion on SLBs, the modification of the bilayer surface charge has been exploited to enhance the electrostatic interaction between the artificial membrane and its biological counterpart. In this work, several SLBs with different lipidic composition were synthesized and interfaced with primary neurons. Starting from a neuron-inspired biomembrane, the negative charges were increased through the addition of 1,2-dipalmitoyl-
Identifiants
pubmed: 36337946
doi: 10.1039/d2ra05147h
pii: d2ra05147h
pmc: PMC9590245
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30270-30277Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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