Clinical and epidemiological features of ulcerative colitis patients in Sardinia, Italy: Results from a multicenter study.
Epidemiology
Inflammatory bowel disease-basic
Inflammatory bowel disease-clinical
Natural history
Treatment
Ulcerative colitis
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
received:
09
08
2021
revised:
06
09
2021
accepted:
22
08
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
ppublish
Résumé
There are little data on the epidemiological and clinical features of adult patients with ulcerative colitis (UC) in the different Italian regions, mainly derived from the absence of a national registry. This prevents correct interpretation of the disease burden. To assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia, Italy. We performed a multicenter, observational, cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in Sardinia. Data were obtained from the patients' medical records and from a questionnaire administered at the inclusion visit. Four hundred and forty-two patients with UC were included. The median age at diagnosis was 39 years (interquartile range 28-48). After a median disease duration of 10 years, 53 patients experienced proximal extension of proctitis or left-sided colitis. Seventy-five patients developed extraintestinal manifestations. Nineteen patients (4.3%) developed cancer: two with colorectal cancer and seventeen with extracolonic cancers. Mesalazine (5-ASA) remains the mainstay of treatment for UC. Overall, 95 patients (21.5%) were treated with one or more biologic agents, whereas 15 patients (3.4%) underwent surgery, mostly colectomy. Our results provide important insights into the clinical and epidemiological features of patients with UC, and while waiting for a national Italian registry, present eligible data on the UC population in Sardinia.
Sections du résumé
BACKGROUND
BACKGROUND
There are little data on the epidemiological and clinical features of adult patients with ulcerative colitis (UC) in the different Italian regions, mainly derived from the absence of a national registry. This prevents correct interpretation of the disease burden.
AIM
OBJECTIVE
To assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia, Italy.
METHODS
METHODS
We performed a multicenter, observational, cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in Sardinia. Data were obtained from the patients' medical records and from a questionnaire administered at the inclusion visit.
RESULTS
RESULTS
Four hundred and forty-two patients with UC were included. The median age at diagnosis was 39 years (interquartile range 28-48). After a median disease duration of 10 years, 53 patients experienced proximal extension of proctitis or left-sided colitis. Seventy-five patients developed extraintestinal manifestations. Nineteen patients (4.3%) developed cancer: two with colorectal cancer and seventeen with extracolonic cancers. Mesalazine (5-ASA) remains the mainstay of treatment for UC. Overall, 95 patients (21.5%) were treated with one or more biologic agents, whereas 15 patients (3.4%) underwent surgery, mostly colectomy.
CONCLUSION
CONCLUSIONS
Our results provide important insights into the clinical and epidemiological features of patients with UC, and while waiting for a national Italian registry, present eligible data on the UC population in Sardinia.
Identifiants
pubmed: 36338227
doi: 10.12998/wjcc.v10.i30.10921
pmc: PMC9631144
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10921-10930Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Références
Nutr Diabetes. 2014 Jun 30;4:e122
pubmed: 24979151
J Crohns Colitis. 2019 Feb 01;13(2):198-208
pubmed: 30289522
Am J Gastroenterol. 2012 Dec;107(12):1879-87
pubmed: 23165448
PLoS One. 2020 Jun 23;15(6):e0235142
pubmed: 32574216
N Engl J Med. 2011 Nov 3;365(18):1713-25
pubmed: 22047562
J Crohns Colitis. 2015 Sep;9(9):747-53
pubmed: 26055976
Int J Epidemiol. 1996 Oct;25(5):1044-52
pubmed: 8921493
Gut. 2019 Jun;68(6):977-984
pubmed: 30420398
Scand J Gastroenterol. 2009;44(4):431-40
pubmed: 19101844
Gut. 2012 Nov;61(11):1619-35
pubmed: 22842618
Scand J Gastroenterol. 2015 Aug;50(8):942-51
pubmed: 25687629
Gut. 2006 Jun;55(6):749-53
pubmed: 16698746
Gut. 2014 Apr;63(4):588-97
pubmed: 23604131
Dig Liver Dis. 2018 Jan;50(1):32-36
pubmed: 28988755
J Crohns Colitis. 2015 Jun;9(6):439-44
pubmed: 25908717
Aliment Pharmacol Ther. 2014 Sep;40(6):629-38
pubmed: 25039715
Expert Rev Gastroenterol Hepatol. 2015 Jan;9(1):91-102
pubmed: 25160668
Gastroenterology. 2020 Apr;158(5):1450-1461
pubmed: 31945371
Am J Gastroenterol. 2012 Aug;107(8):1228-35
pubmed: 22613902
Dig Liver Dis. 2019 Sep;51(9):1270-1274
pubmed: 31176630
Aliment Pharmacol Ther. 2017 Jun;45(12):1481-1492
pubmed: 28449361
J Clin Gastroenterol. 2008 May-Jun;42(5):527-32
pubmed: 18277889
Nat Rev Gastroenterol Hepatol. 2013 Oct;10(10):585-95
pubmed: 23835489
World J Gastroenterol. 2016 Feb 21;22(7):2179-94
pubmed: 26900283
J Crohns Colitis. 2014 Jun;8(6):443-68
pubmed: 24613021
Gastroenterology. 2017 Feb;152(2):313-321.e2
pubmed: 27793607
Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3
pubmed: 28625817
Gut. 2019 Dec;68(Suppl 3):s1-s106
pubmed: 31562236
Dig Liver Dis. 2014 Sep;46(9):777-82
pubmed: 24890621
Inflamm Bowel Dis. 2021 Jan 1;27(1):1-9
pubmed: 32440680
Aliment Pharmacol Ther. 2002 Jan;16(1):51-60
pubmed: 11856078
Am J Gastroenterol. 2000 Feb;95(2):469-73
pubmed: 10685752
Inflamm Bowel Dis. 2011 Jun;17(6):1415-22
pubmed: 21560202
Gut. 1994 Feb;35(2):231-5
pubmed: 7508411
Int J Epidemiol. 2007 Aug;36(4):890-9
pubmed: 17420164
J Infect. 2017 May;74(5):433-441
pubmed: 28263759
J Crohns Colitis. 2013 Mar;7(2):113-9
pubmed: 22464811
J Crohns Colitis. 2018 Jan 5;12(1):17-31
pubmed: 28981623
J Crohns Colitis. 2013 May;7(4):322-37
pubmed: 23395397