Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity.
adipogenesis
human adipocytes
immunogenic adipocytes
obesity
subcutaneous adipocytes
visceral adipocytes
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
07
2022
accepted:
03
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
epublish
Résumé
Abdominal obesity associates with cardiometabolic disease and an accumulation of lipids in the visceral adipose depot, whereas lipid accumulation in the subcutaneous depot is more benign. We aimed to further investigate whether the adipogenic properties where cell-intrinsic, or dependent on a depot-specific or obesity-produced microenvironment. We obtained visceral and subcutaneous biopsies from non-obese women (
Identifiants
pubmed: 36340033
doi: 10.3389/fcell.2022.983899
pii: 983899
pmc: PMC9629396
doi:
Types de publication
Journal Article
Langues
eng
Pagination
983899Informations de copyright
Copyright © 2022 Mathur, Severinsen, Jensen, Naver, Schrölkamp, Laye, Watt, Nielsen, Krogh-Madsen, Pedersen and Scheele.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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