The outcome of severely injured patients following traumatic brain injury is affected by gender-A retrospective, multicenter, matched-pair analysis utilizing data of the TraumaRegister DGU
estradiol
female steroid hormones
matched-pair analysis
mortality
traumatic brain injury
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
06
2022
accepted:
04
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
epublish
Résumé
Traumatic brain injury (TBI) causes a major health-concern globally. Gender-dependent differences in mortality outcome after TBI have been controversially discussed. We conducted a retrospective, multicenter, matched-pair analysis using data collected by the TraumaRegister DGU Average age at injury was 67.5 ± 19.6 years in women and 66.7 ± 19.1 years in men. Mean Injury Severity Score (ISS) was 21.3 ± 8.1 in women and 21.6 ± 8.2 in men. While women were more likely to die within the first week after trauma, the mortality was significantly higher in men overall (30.8 vs. 29.2%, Gender-specific differences in the clinical outcome of severely injured patients with leading TBI could be detected. While women are overall characterized by an advantage in survival, this feature is not equally reproducible in premenopausal women. Therefore, the exact pathophysiological reasons for the described survival advantages of women will have to be explored in further prospective clinical studies.
Identifiants
pubmed: 36340759
doi: 10.3389/fnins.2022.974519
pmc: PMC9627281
doi:
Types de publication
Journal Article
Langues
eng
Pagination
974519Informations de copyright
Copyright © 2022 Mair, Greve, Lefering, Biberthaler, Hanschen and the TraumaRegister DGU.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurotrauma. 2011 Jun;28(6):871-88
pubmed: 21488721
Obstet Gynecol Clin North Am. 2011 Sep;38(3):425-40
pubmed: 21961711
Injury. 2007 Dec;38(12):1392-400
pubmed: 18048036
Crit Care. 2013 Nov 29;17(6):R277
pubmed: 24289182
N Engl J Med. 2014 Dec 25;371(26):2467-76
pubmed: 25493978
Injury. 2014 Oct;45 Suppl 3:S20-8
pubmed: 25284229
J Neurotrauma. 2021 Jan 15;38(2):235-251
pubmed: 32838645
Crit Care. 2014 Sep 05;18(5):476
pubmed: 25394596
Shock. 2016 Sep;46(3 Suppl 1):4-11
pubmed: 27380534
Lancet Neurol. 2017 Dec;16(12):987-1048
pubmed: 29122524
J Neurosurg. 2017 Jul;127(1):23-31
pubmed: 27662529
Front Neurosci. 2021 May 05;15:681599
pubmed: 34025346
J Neurotrauma. 2013 Jan 1;30(1):47-54
pubmed: 21851230
N Engl J Med. 2014 Dec 25;371(26):2457-66
pubmed: 25493974
Mil Med Res. 2018 Oct 26;5(1):35
pubmed: 30360757
Int J Crit Illn Inj Sci. 2016 Apr-Jun;6(2):70-3
pubmed: 27308254
Chin Neurosurg J. 2019 Oct 4;5:24
pubmed: 32922923
J Trauma. 2009 Nov;67(5):950-3
pubmed: 19901653
J Neurotrauma. 2015 Aug 15;32(16):1210-6
pubmed: 25646701
Injury. 2006 Dec;37(12):1083-91
pubmed: 17092503
Intensive Care Med. 1996 Jul;22(7):707-10
pubmed: 8844239
Can J Physiol Pharmacol. 2010 Apr;88(4):414-21
pubmed: 20555409
Shock. 2007 Feb;27(2):151-6
pubmed: 17224789
Ann Surg. 2015 Apr;261(4):774-80
pubmed: 25029437
Lancet Public Health. 2016 Dec;1(2):e76-e83
pubmed: 29253420
Endocr Metab Immune Disord Drug Targets. 2006 Jun;6(2):127-35
pubmed: 16787286
Immunobiology. 2016 Aug;221(8):904-10
pubmed: 27017325