Mithplatins: Mithramycin SA-Pt(II) Complex Conjugates for the Treatment of Platinum-Resistant Ovarian Cancers.
DNA cross linking
Mithramycin
Ovarian cancer
Platinum complexes
Platinum resistance
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
revised:
04
11
2022
received:
08
07
2022
pmc-release:
01
02
2024
pubmed:
8
11
2022
medline:
8
2
2023
entrez:
7
11
2022
Statut:
ppublish
Résumé
DNA coordinating platinum (Pt) containing compounds cisplatin and carboplatin have been used for the treatment of ovarian cancer therapy for four decades. However, recurrent Pt-resistant cancers are a major cause of mortality. To combat Pt-resistant ovarian cancers, we designed and synthesized a conjugate of an anticancer drug mithramycin with a reactive Pt(II) bearing moiety, which we termed mithplatin. The conjugates displayed both the Mg
Identifiants
pubmed: 36342449
doi: 10.1002/cmdc.202200368
pmc: PMC9899322
mid: NIHMS1848926
doi:
Substances chimiques
Cisplatin
Q20Q21Q62J
Plicamycin
NIJ123W41V
Antineoplastic Agents
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200368Subventions
Organisme : NCI NIH HHS
ID : P30CA177558
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243529
Pays : United States
Organisme : NIH HHS
ID : S10 OD028690
Pays : United States
Informations de copyright
© 2022 Wiley-VCH GmbH.
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