BCL-2 protein family: attractive targets for cancer therapy.
Apoptosis
BCL-2 protein family
BH3-mimetic drugs
BH3-only proteins
Pro-apoptotic BCL-2 family members
Pro-survival BCL-2 proteins
Journal
Apoptosis : an international journal on programmed cell death
ISSN: 1573-675X
Titre abrégé: Apoptosis
Pays: Netherlands
ID NLM: 9712129
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
accepted:
10
10
2022
pubmed:
8
11
2022
medline:
3
3
2023
entrez:
7
11
2022
Statut:
ppublish
Résumé
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic cell death. Abnormal over-expression of pro-survival BCL-2 family members or abnormal reduction of pro-apoptotic BCL-2 family proteins, both resulting in the inhibition of apoptosis, are frequently detected in diverse malignancies. The critical role of the pro-survival and pro-apoptotic BCL-2 family proteins in the regulation of apoptosis makes them attractive targets for the development of agents for the treatment of cancer. This review describes the roles of the various pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal function and how defects in the control of apoptosis promote the development and therapy resistance of cancer. Finally, we discuss the development of inhibitors of pro-survival BCL-2 proteins, termed BH3-mimetic drugs, as novel agents for cancer therapy.
Identifiants
pubmed: 36342579
doi: 10.1007/s10495-022-01780-7
pii: 10.1007/s10495-022-01780-7
pmc: PMC9950219
doi:
Substances chimiques
Proto-Oncogene Proteins c-bcl-2
0
Apoptosis Regulatory Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-38Informations de copyright
© 2022. The Author(s).
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