Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process.
Bufadienolide
Malaria
Rhinella marina
Separative techniques
Toad venom
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
10
05
2022
revised:
16
09
2022
accepted:
07
10
2022
pubmed:
8
11
2022
medline:
15
12
2022
entrez:
7
11
2022
Statut:
ppublish
Résumé
Malaria remains to date one of the most devastating parasitic diseases worldwide. The fight against this disease is rendered more difficult by the emergence and spread of drug-resistant strains. The need for new therapeutic candidates is now greater than ever. In this study, we investigated the antiplasmodial potential of toad venoms. The wide array of bioactive compounds present in Bufonidae venoms has allowed researchers to consider many potential therapeutic applications, especially for cancers and infectious diseases. We focused on small molecules, namely bufadienolides, found in the venom of Rhinella marina (L.). The developed bio-guided fractionation process includes a four solvent-system extraction followed by fractionation using flash chromatography. Sub-fractions were obtained through preparative TLC. All samples were characterized using chromatographic and spectrometric techniques and then underwent testing on in vitro Plasmodium falciparum cultures. Two strains were considered: 3D7 (chloroquine-sensitive) and W2 (chloroquine-resistant). This strategy highlighted a promising activity for one compound named resibufogenin. With IC
Identifiants
pubmed: 36343571
pii: S2211-3207(22)00022-7
doi: 10.1016/j.ijpddr.2022.10.001
pmc: PMC9772263
pii:
doi:
Substances chimiques
Amphibian Venoms
0
Antimalarials
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-107Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
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