A multi-marker integrative analysis reveals benefits and risks of bariatric surgery.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 11 2022
07 11 2022
Historique:
received:
17
05
2022
accepted:
27
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
10
11
2022
Statut:
epublish
Résumé
Bariatric surgery (BS) is an effective intervention for severe obesity and associated comorbidities. Although several studies have addressed the clinical and metabolic effects of BS, an integrative analysis of the complex body response to surgery is still lacking. We conducted a longitudinal data study with 36 patients with severe obesity who were tested before, 6 and 12 months after restrictive BS for more than one hundred blood biomarkers, including clinical, oxidative stress and metabolic markers, peptide mediators and red blood cell membrane lipids. By using a synthetic data-driven modeling based on principal component and correlation analyses, we provided evidence that, besides the early, well-known glucose metabolism- and weight loss-associated beneficial effects of BS, a tardive, weight-independent increase of the hepatic cholesterol metabolism occurs that is associated with potentially detrimental inflammatory and metabolic effects. Canonical correlation analysis indicated that oxidative stress is the most predictive feature of the BS-induced changes of both glucose and lipids metabolism. Our results show the power of multi-level correlation analysis to uncover the network of biological pathways affected by BS. This approach highlighted potential health risks of restrictive BS that are disregarded with the current practice to use weight loss as surrogate of BS success.
Identifiants
pubmed: 36344536
doi: 10.1038/s41598-022-23241-6
pii: 10.1038/s41598-022-23241-6
pmc: PMC9640526
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18877Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2017L8Z2EM_006
Organisme : Ministero della Salute
ID : 2013-02357791
Informations de copyright
© 2022. The Author(s).
Références
Metabolism. 2019 Mar;92:61-70
pubmed: 30586573
Redox Biol. 2017 Aug;12:389-402
pubmed: 28319890
J Lipid Res. 2013 Mar;54(3):852-858
pubmed: 23264677
Metabolism. 2021 Feb;115:154441
pubmed: 33248063
Diabetes. 2014 Jul;63(7):2344-55
pubmed: 24550188
Curr Opin Lipidol. 2009 Feb;20(1):39-44
pubmed: 19133410
J Clin Med. 2021 Nov 25;10(23):
pubmed: 34884217
Ann Nutr Metab. 2021;77(4):221-230
pubmed: 34233321
BMC Nephrol. 2016 Aug 26;17(1):120
pubmed: 27566671
Clin Chem. 1995 Jun;41(6 Pt 1):924-7
pubmed: 7768014
Gastroenterology. 2019 Jul;157(1):119-127.e1
pubmed: 30940524
Obes Surg. 2016 May;26(5):1041-7
pubmed: 26220239
Clin Chim Acta. 2012 May 18;413(9-10):901-6
pubmed: 22336637
J Biol Chem. 2009 Apr 17;284(16):10601-9
pubmed: 19237544
Nutr Diabetes. 2015 Aug 10;5:e175
pubmed: 26258766
Cells. 2019 Apr 28;8(5):
pubmed: 31035320
N Engl J Med. 2020 Oct 15;383(16):1535-1543
pubmed: 33053284
Lancet. 2005 Sep 24-30;366(9491):1059-62
pubmed: 16182882
Phys Life Rev. 2021 Jul;37:17-64
pubmed: 33765608
Intern Med. 2018 Oct 15;57(20):2929-2935
pubmed: 29877283
Clin Chem. 1999 Feb;45(2):290-2
pubmed: 9931056
Biology (Basel). 2020 May 27;9(6):
pubmed: 32471147
Aging Cell. 2022 Jul;21(7):e13605
pubmed: 35670027
FEBS J. 2007 Aug;274(15):3855-63
pubmed: 17617229
Metab Syndr Relat Disord. 2015 Dec;13(10):423-44
pubmed: 26569333
Antioxidants (Basel). 2020 Oct 20;9(10):
pubmed: 33092099
Lancet. 2005 Oct 1;366(9492):1197-209
pubmed: 16198769
Nat Protoc. 2007;2(11):2692-703
pubmed: 18007604
Free Radic Biol Med. 2013 Dec;65:244-253
pubmed: 23747983
N Engl J Med. 2016 Aug 25;375(8):794-8
pubmed: 27557308
Nutr Diabetes. 2017 Sep 4;7(9):e285
pubmed: 28869586
J Intern Med. 2013 Mar;273(3):219-34
pubmed: 23163728
Free Radic Biol Med. 2002 Dec 1;33(11):1516-26
pubmed: 12446209
Drug Discov Today. 2017 Jul;22(7):1069-1076
pubmed: 28111329
Diabetes. 2014 Jul;63(7):2216-8
pubmed: 24962921
Stem Cells Dev. 2013 Mar 15;22(6):878-88
pubmed: 23025577
J Chromatogr. 1985 Dec 13;345(2):275-84
pubmed: 4086599
Front Physiol. 2021 Jun 11;12:640191
pubmed: 34177607
Int J Mol Sci. 2014 Dec 26;16(1):401-19
pubmed: 25548897
Obes Surg. 2018 Jul;28(7):2117-2121
pubmed: 29725979
Bioinformatics. 2020 Nov 1;36(17):4616-4625
pubmed: 32437529
BMC Bioinformatics. 2014 May 29;15:162
pubmed: 24884486
Life Sci. 2016 Mar 1;148:183-93
pubmed: 26851532
J Pers Med. 2021 Apr 23;11(5):
pubmed: 33922764
Endocrine. 2018 Feb;59(2):288-295
pubmed: 29168114
PLoS One. 2016 Apr 05;11(4):e0152378
pubmed: 27045677
Diabetologia. 2011 Aug;54(8):2093-102
pubmed: 21614570
Adv Exp Med Biol. 2017;960:545-570
pubmed: 28585216
J Clin Invest. 2011 Jun;121(6):2111-7
pubmed: 21633179
J Clin Invest. 2004 Dec;114(12):1752-61
pubmed: 15599400
Ann N Y Acad Sci. 2002 Jun;967:183-95
pubmed: 12079847