Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
07 Nov 2022
07 Nov 2022
Historique:
received:
02
02
2022
accepted:
11
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
8
11
2022
Statut:
epublish
Résumé
Cognitive impairment is a debilitating symptom in Parkinson's disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases from the Parkinson's Progression Markers Initiative (PPMI). Annual cognitive assessments over an 8-year time span were used to define two cognitive outcomes of (i) cognitive impairment, and (ii) dementia conversion. Selected baseline variables were organized into three subsets of clinical, biofluid and genetic/epigenetic measures and tested using four different ML algorithms. Irrespective of the ML algorithm used, the models consisting of the clinical variables performed best and showed better prediction of cognitive impairment outcome over dementia conversion. We observed a marginal improvement in the prediction performance when clinical, biofluid, and epigenetic/genetic variables were all included in one model. Several cerebrospinal fluid measures and an epigenetic marker showed high predictive weighting in multiple models when included alongside clinical variables.
Identifiants
pubmed: 36344548
doi: 10.1038/s41531-022-00409-5
pii: 10.1038/s41531-022-00409-5
pmc: PMC9640625
doi:
Types de publication
Journal Article
Langues
eng
Pagination
150Subventions
Organisme : Medical Research Council
ID : MR/S011625/1
Pays : United Kingdom
Organisme : ZonMw (Netherlands Organisation for Health Research and Development)
ID : 733050516
Informations de copyright
© 2022. The Author(s).
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