Cryo-EM structures of prefusion SIV envelope trimer.

Animals Cryoelectron Microscopy Macaca mulatta / metabolism Antibodies, Neutralizing HIV-1 / metabolism Electron Microscope Tomography env Gene Products, Human Immunodeficiency Virus / chemistry HIV Antibodies

Journal

Nature structural & molecular biology
ISSN: 1545-9985
Titre abrégé: Nat Struct Mol Biol
Pays: United States
ID NLM: 101186374

Informations de publication

Date de publication:
11 2022
Historique:
received: 03 11 2021
accepted: 25 09 2022
pubmed: 8 11 2022
medline: 18 11 2022
entrez: 7 11 2022
Statut: ppublish

Résumé

Simian immunodeficiency viruses (SIVs) are lentiviruses that naturally infect non-human primates of African origin and seeded cross-species transmissions of HIV-1 and HIV-2. Here we report prefusion stabilization and cryo-EM structures of soluble envelope (Env) trimers from rhesus macaque SIV (SIV

Identifiants

DOI: 10.1038/s41594-022-00852-1 PMID: 36344847 PMC: PMC10606957
pubmed: 36344847
doi: 10.1038/s41594-022-00852-1
pii: 10.1038/s41594-022-00852-1
pmc: PMC10606957
mid: NIHMS1928771
doi:

Substances chimiques

Antibodies, Neutralizing 0
env Gene Products, Human Immunodeficiency Virus 0
HIV Antibodies 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1080-1091

Subventions

Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103310
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150560
Pays : United States
Organisme : NIH HHS
ID : S10 OD023603
Pays : United States

Informations de copyright

© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Jason Gorman (J)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-3775-6560

Chunyan Wang (C)

Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.
Microbial Sciences Institute, Yale University, West Haven, CT, USA.

Rosemarie D Mason (RD)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Alexandra F Nazzari (AF)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Hugh C Welles (HC)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Tongqing Zhou (T)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-3935-4637

Julian W Bess (JW)

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
ORCID: 0000-0003-0662-7843

Tatsiana Bylund (T)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Myungjin Lee (M)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-4972-3811

Yaroslav Tsybovsky (Y)

Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
ORCID: 0000-0002-2159-5248

Raffaello Verardi (R)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Shuishu Wang (S)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-0865-4522

Yongping Yang (Y)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Baoshan Zhang (B)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.

Reda Rawi (R)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-0445-2325

Brandon F Keele (BF)

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
ORCID: 0000-0002-2381-1151

Jeffrey D Lifson (JD)

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Jun Liu (J)

Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA. jliu@yale.edu.
Microbial Sciences Institute, Yale University, West Haven, CT, USA. jliu@yale.edu.
ORCID: 0000-0003-3108-6735

Mario Roederer (M)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA. roederer@nih.gov.
ORCID: 0000-0001-7448-7040

Peter D Kwong (PD)

Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA. pdkwong@nih.gov.
ORCID: 0000-0003-3560-232X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à transmission › Tomographie en microscopie électronique › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Produits du gène env du virus de l'immunodéficience humaine › Cryo-EM structures of prefusion SIV envelope trimer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Cryo-EM structures of prefusion SIV envelope trimer.