Prevalence of congenital heart defects in Europe, 2008-2015: A registry-based study.
European Surveillance of Congenital Anomalies
congenital heart disease
prevalence rate
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
01 12 2022
01 12 2022
Historique:
revised:
28
09
2022
received:
04
07
2022
accepted:
14
10
2022
pubmed:
9
11
2022
medline:
3
12
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
The total prevalence of congenital heart defects (CHDs) varies by populations and over time. Studies that examine trends in the prevalence of CHD in different regions may shed light on our understanding of the occurrence of CHD and the impact of different risk factors. To examine trends in total and live birth prevalence of nonsyndromic CHD in Europe between the years 2008 and 2015 and to investigate if the decreasing trend reported by previous studies is continuing. Cases of CHD delivered between January 1, 2008 and December 31, 2015 notified to 25 population-based EUROCAT (European Surveillance of Congenital Anomalies) registries in 14 countries, formed the population-based case-series. Prevalence (total/live) rates and 95% confidence intervals were calculated as the number of cases per 10,000 births (live and stillbirths). Time trends in prevalence of all nonsyndromic CHDs and for three CHD severity groups (very severe, severe, and less severe) were plotted using a Poisson regression multilevel approach. The total prevalence of nonsyndromic CHD was 57.1 per 10,000 births (live births and stillbirths) for the 8-year period and remained stable across the three CHD severity groups while the live birth prevalence was 60.2 per 10,000 births. There was considerable variation in the reported total CHD prevalence and the direction of trends by registry. A decreasing prevalence of CHD was observed for the Norway and England/Wales registries, whereas the CHD prevalence increased for registries in Italy and Croatia. The total prevalence of CHD in Europe between the years 2008 and 2015 remained stable for all CHD and across the three CHD severity groups. The decreasing trend reported by previous studies has not continued. However, we found significant differences in the total and live birth prevalence by registry.
Sections du résumé
BACKGROUND
The total prevalence of congenital heart defects (CHDs) varies by populations and over time. Studies that examine trends in the prevalence of CHD in different regions may shed light on our understanding of the occurrence of CHD and the impact of different risk factors.
OBJECTIVES
To examine trends in total and live birth prevalence of nonsyndromic CHD in Europe between the years 2008 and 2015 and to investigate if the decreasing trend reported by previous studies is continuing.
METHODS
Cases of CHD delivered between January 1, 2008 and December 31, 2015 notified to 25 population-based EUROCAT (European Surveillance of Congenital Anomalies) registries in 14 countries, formed the population-based case-series. Prevalence (total/live) rates and 95% confidence intervals were calculated as the number of cases per 10,000 births (live and stillbirths). Time trends in prevalence of all nonsyndromic CHDs and for three CHD severity groups (very severe, severe, and less severe) were plotted using a Poisson regression multilevel approach.
RESULTS
The total prevalence of nonsyndromic CHD was 57.1 per 10,000 births (live births and stillbirths) for the 8-year period and remained stable across the three CHD severity groups while the live birth prevalence was 60.2 per 10,000 births. There was considerable variation in the reported total CHD prevalence and the direction of trends by registry. A decreasing prevalence of CHD was observed for the Norway and England/Wales registries, whereas the CHD prevalence increased for registries in Italy and Croatia.
CONCLUSIONS
The total prevalence of CHD in Europe between the years 2008 and 2015 remained stable for all CHD and across the three CHD severity groups. The decreasing trend reported by previous studies has not continued. However, we found significant differences in the total and live birth prevalence by registry.
Identifiants
pubmed: 36345679
doi: 10.1002/bdr2.2117
pmc: PMC10098845
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1404-1416Subventions
Organisme : Medical Research Council
ID : MR/K02325X/1
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Birth Defects Research published by Wiley Periodicals LLC.
Références
Birth Defects Res A Clin Mol Teratol. 2011 Mar;91 Suppl 1:S16-22
pubmed: 21381186
Pediatr Rev. 1986 Oct;8(4):122-6
pubmed: 3332343
Curr Cardiol Rev. 2010 May;6(2):91-7
pubmed: 21532774
Heart. 2015 Nov;101(22):1807-12
pubmed: 26412859
Pediatr Cardiol. 2014 Oct;35(7):1232-8
pubmed: 24823884
Int J Epidemiol. 2019 Apr 1;48(2):455-463
pubmed: 30783674
Am J Med Genet. 1988 Jan;29(1):171-85
pubmed: 3125743
PLoS One. 2019 Feb 7;14(2):e0211976
pubmed: 30730998
Congenit Heart Dis. 2015 Sep-Oct;10(5):437-46
pubmed: 25196372
Epidemiology. 2020 Jul;31(4):587-594
pubmed: 32427635
Matern Child Nutr. 2017 Oct;13(4):
pubmed: 27928892
Am Heart J. 2014 Dec;168(6):956-64
pubmed: 25458661
Birth Defects Res. 2022 Dec 1;114(20):1404-1416
pubmed: 36345679
J Pediatr. 2013 Jan;162(1):108-13.e2
pubmed: 22835879
J Prenat Med. 2012 Oct;6(4):59-63
pubmed: 23272276
Hum Reprod. 2009 Feb;24(2):360-6
pubmed: 19010807
J Am Coll Cardiol. 2011 Nov 15;58(21):2241-7
pubmed: 22078432
Congenit Heart Dis. 2012 Jan-Feb;7(1):46-9
pubmed: 22010848
Matern Child Health J. 2006 Jan;10(1):75-81
pubmed: 16240077
Circulation. 2011 Mar 1;123(8):841-9
pubmed: 21321151
J Epidemiol Community Health. 2000 Sep;54(9):660-6
pubmed: 10942444
J Pediatr. 2015 Apr;166(4):801-4
pubmed: 25681204
Eur J Epidemiol. 2019 Apr;34(4):383-396
pubmed: 30661159
Arch Dis Child Fetal Neonatal Ed. 2005 Sep;90(5):F374-9
pubmed: 16113153
J Expo Sci Environ Epidemiol. 2016 Jun;26(4):422-7
pubmed: 26883477