Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis.
cortical development
lineage specification
networks
signaling pathways
transcriptional landscape
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 12 2022
15 12 2022
Historique:
revised:
09
09
2022
received:
10
03
2022
accepted:
26
09
2022
pubmed:
9
11
2022
medline:
17
12
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
Identifiants
pubmed: 36345783
doi: 10.15252/embj.2022111132
pmc: PMC9753470
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e111132Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102228
Pays : United States
Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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