Efficacy and safety of date palm leaf-based ointment for treatment of cutaneous warts: A pilot clinical trial.
WartOver
cutaneous warts
herbal medicine
human papilloma virus
natural therapeutic
nongenital warts
topical treatment
verrucae
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
20
09
2022
received:
10
06
2022
accepted:
21
10
2022
pubmed:
9
11
2022
medline:
21
12
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
Despite the considerably high prevalence of cutaneous warts, no optimally effective and safe treatment is available. Leaves of date palm (Phoenix dactylifera L.; Arecaceae) have long been used in Iran's folk medicine as a remedy for warts. To assess the state-of-the-art evidence on using P. dactylifera L. for warts, we conducted a systematic review using CINAHL (via EBSCO), Embase, Medline (via PubMed), ProQuest, Scopus, and Web of Science. We conducted an open-label uncontrolled pilot clinical study to evaluate the efficacy and safety of a proprietary topical date palm leaf-based ointment for the treatment of various types of nongenital warts. This study consisted of an 8-week treatment phase and a 4-week follow-up phase. The assessed outcomes included complete clearance, patient satisfaction (on Likert scale), and the occurrence of any adverse effect. The systematic review demonstrated that the effects of date palm on warts have not been scientifically studied. Thirty patients entered the study with a mean age of 29.5 years (SD = 14.04); among which 17 were female and 13 were male. The patients presented diverse types of warts: verruca vulgaris 15 (50%), plantar 9 (30%), plane 2 (7%), periungual 2 (7%), and warts at multiple sites 2 (7%). In this trial, 19 patients (63.3%) experienced complete clearance and 5 patients (16.6%) experienced partial clearance. Eight patients (26.67%) dropped out during the study. 21 (70%) patients were very satisfied (score on Likert scale = 5) while 1 (3.3%) patient with partial clearance was somewhat satisfied (score on Likert scale = 4). No adverse effect was observed. The results of this pilot study indicate that the date palm leaf-based ointment is a promising treatment whose efficacy and safety should be further investigated in a randomized controlled clinical trial.
Substances chimiques
Ointments
0
Types de publication
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15968Subventions
Organisme : Aras Pharmaceuticals Ltd.
Informations de copyright
© 2022 Wiley Periodicals LLC.
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Preregistration and proposal details of Evaluation of the efficacy and safety of ([WartOver]) topical ointment for the treatment of cutaneous warts: a randomized triple-blind clinical trial. 2022; https://ethics.research.ac.ir/EthicsProposalViewEn.php?id=280295.