A State of Natriuretic Peptide Deficiency.
ANP
BNP
CNP
hypertension
natriuretic peptide
obesity
Journal
Endocrine reviews
ISSN: 1945-7189
Titre abrégé: Endocr Rev
Pays: United States
ID NLM: 8006258
Informations de publication
Date de publication:
08 05 2023
08 05 2023
Historique:
received:
13
07
2022
medline:
10
5
2023
pubmed:
9
11
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker, especially in the context of heart failure (HF). In contrast, a state of partial NP deficiency appears integral to several conditions in which lower NP concentrations in plasma presage overt cardiometabolic disease. Here, obesity and type 2 diabetes have attracted considerable attention. Other factors-including age, sex, race, genetics, and diurnal regulation-affect the NP "armory" and may leave some individuals more prone to development of cardiovascular disease. The molecular maturation of NPs has also proven complex, with highly variable O-glycosylation within the biosynthetic precursors. The relevance of this regulatory step in post-translational propeptide maturation has recently become recognized in biomarker measurement/interpretation and cardiovascular pathophysiology. An important proportion of people appear to have reduced effective net NP bioactivity in terms of receptor activation and physiological effects. The state of NP deficiency both entails a potential for further biomarker development and could also offer novel pharmacological possibilities. Alleviating the state of NP deficiency before development of overt cardiometabolic disease in selected patients could be a future path for improving precision medicine.
Identifiants
pubmed: 36346821
pii: 6811787
doi: 10.1210/endrev/bnac029
pmc: PMC10166265
doi:
Substances chimiques
Natriuretic Peptide, Brain
114471-18-0
Atrial Natriuretic Factor
85637-73-6
Natriuretic Peptides
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-392Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.
Déclaration de conflit d'intérêts
Conflict of Interest M.N., T.P.L, N.B.M., S.Z.A., and M.E. are employees at Novo Nordisk. The company has no products relating to the current manuscript. J.P.G. has received an honorarium from Novo for advice on biomarker measurement. All other authors are university-affiliated and have no conflicts of interest to declare.
Références
Heart. 2019 Oct;105(20):1590-1596
pubmed: 31152069
Regul Pept. 2010 Feb 25;160(1-3):140-5
pubmed: 20035806
J Card Fail. 2021 Nov;27(11):1231-1239
pubmed: 34133968
Diabetes. 2012 Oct;61(10):2592-6
pubmed: 22698919
Am J Cardiol. 2008 Feb 4;101(3A):39-42
pubmed: 18243857
Endocr Connect. 2014 Jan 21;3(1):11-6
pubmed: 24327600
Eur Heart J. 2022 May 21;43(20):1941-1951
pubmed: 35139159
Pediatr Diabetes. 2016 Feb;17(1):21-7
pubmed: 25384349
Circ Heart Fail. 2008 Nov;1(4):258-64
pubmed: 19808300
J Am Heart Assoc. 2015 May 21;4(5):
pubmed: 25999400
Endocrinology. 1992 Jan;130(1):229-39
pubmed: 1309330
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8525-9
pubmed: 10880574
J Am Coll Cardiol. 2002 Sep 4;40(5):976-82
pubmed: 12225726
J Am Coll Cardiol. 2011 Aug 2;58(6):618-26
pubmed: 21798425
PLoS One. 2020 Feb 21;15(2):e0229280
pubmed: 32084251
Circulation. 2005 Oct 18;112(16):2403-10
pubmed: 16216958
Am J Cardiol. 2018 Nov 1;122(9):1578-1587
pubmed: 30220416
Clin Chem. 2012 Apr;58(4):789-92
pubmed: 22282468
Clin Chem Lab Med. 2009;47(3):248-52
pubmed: 19327104
Am J Hum Genet. 2018 Aug 2;103(2):288-295
pubmed: 30032985
Diabetes Care. 2015 Jan;38(1):132-9
pubmed: 25414155
Clin Chem Lab Med. 2018 Jun 27;56(7):1015-1025
pubmed: 29381470
J Am Coll Cardiol. 2007 Dec 18;50(25):2357-68
pubmed: 18154959
Eur Heart J. 2007 Oct;28(20):2427-9
pubmed: 17872916
Eur J Heart Fail. 2015 Dec;17(12):1231-9
pubmed: 26493383
Pediatr Diabetes. 2009 Dec;10(8):513-21
pubmed: 19708908
N Engl J Med. 1986 Sep 11;315(11):710-1
pubmed: 2943993
Hum Mutat. 2007 Jul;28(7):724-31
pubmed: 17373680
PLoS One. 2012;7(8):e43238
pubmed: 22916229
Clin Chem. 2022 May 18;68(5):713-720
pubmed: 35175317
PLoS One. 2014 Feb 19;9(2):e89201
pubmed: 24586593
Front Physiol. 2021 May 21;12:674254
pubmed: 34093235
Peptides. 2020 Oct;132:170363
pubmed: 32634451
Adv Clin Chem. 2012;58:45-8
pubmed: 22950342
Clin Chem. 2019 Sep;65(9):1115-1124
pubmed: 31092393
JACC Heart Fail. 2021 Sep;9(9):697
pubmed: 34474921
Am J Cardiol. 2002 Aug 1;90(3):254-8
pubmed: 12127613
Curr Hypertens Rep. 2014 Feb;16(2):415
pubmed: 24407448
Hypertension. 2009 Sep;54(3):612-8
pubmed: 19620509
Diabetes Obes Metab. 2016 Jun;18(6):581-9
pubmed: 26910107
Gene. 2015 Aug 10;567(2):159-63
pubmed: 25934190
Hum Mol Genet. 2009 Jul 1;18(13):2495-501
pubmed: 19377085
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4016-21
pubmed: 11259675
JACC Heart Fail. 2021 Jun;9(6):465
pubmed: 34082899
Circ Heart Fail. 2011 May;4(3):355-60
pubmed: 21292992
Scand J Clin Lab Invest. 1995 Aug;55(5):447-52
pubmed: 8545604
Clin Pharmacokinet. 2022 Feb;61(2):263-280
pubmed: 34431071
Drugs. 2021 Nov;81(17):2057-2062
pubmed: 34694597
Diabetes Care. 2021 Feb;44(2):595-603
pubmed: 33323477
Nat Genet. 2009 Mar;41(3):348-53
pubmed: 19219041
J Bone Miner Metab. 2002;20(6):331-6
pubmed: 12434160
Nat Commun. 2020 Aug 20;11(1):4033
pubmed: 32820167
Arch Med Sci. 2017 Apr 1;13(3):568-574
pubmed: 28507570
Clin Chem. 2012 Jan;58(1):83-91
pubmed: 22126935
Eur J Heart Fail. 2012 Jan;14(1):22-31
pubmed: 22140234
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1522-9
pubmed: 15142846
Med Sci Monit. 2003 Dec;9(12):CR505-10
pubmed: 14646971
Int J Cardiol. 1994 Oct;46(3):229-33
pubmed: 7814177
Biochem J. 1988 Mar 15;250(3):665-70
pubmed: 2968787
J Am Coll Cardiol. 2012 May 15;59(20):1763-70
pubmed: 22575314
EBioMedicine. 2017 Mar;17:88-94
pubmed: 28262549
Diabetes Obes Metab. 2013 Jul;15(7):607-12
pubmed: 23216672
Horm Metab Res. 2000 Nov-Dec;32(11-12):485-99
pubmed: 11246814
Obes Rev. 2017 Nov;18(11):1243-1259
pubmed: 28901677
Clin Chem. 2013 Aug;59(8):1270-1
pubmed: 23596134
Eur Heart J. 2007 Oct;28(20):2465-71
pubmed: 17766928
Am J Nephrol. 1989;9(1):1-24
pubmed: 2524162
J Appl Physiol (1985). 2004 Jul;97(1):173-9
pubmed: 14990550
Hum Mol Genet. 2016 Apr 15;25(R1):R2-8
pubmed: 26443596
J Nephrol. 1998 Nov-Dec;11(6):296-9
pubmed: 10048495
J Am Coll Cardiol. 2019 Mar 26;73(11):1288-1296
pubmed: 30898204
Int J Mol Sci. 2018 Feb 11;19(2):
pubmed: 29439446
J Clin Invest. 1972 Jun;51(6):1476-85
pubmed: 4336941
Biochem Biophys Res Commun. 1995 Sep 25;214(3):1175-83
pubmed: 7575527
J Clin Endocrinol Metab. 1986 Sep;63(3):669-74
pubmed: 2942555
Clin Chem. 2006 Jan;52(1):82-7
pubmed: 16254193
Circ Res. 2000 Apr 28;86(8):841-5
pubmed: 10785505
Hum Mol Genet. 2007 Jun 1;16(11):1343-50
pubmed: 17412758
Clin Endocrinol (Oxf). 2013 May;78(5):783-9
pubmed: 22963390
Am J Hypertens. 2015 Jun;28(6):772-9
pubmed: 25468806
Clin Chem. 2017 May;63(5):1040-1041
pubmed: 28320761
Clin Chem. 2021 Mar 31;67(4):662-671
pubmed: 33788936
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17442-7
pubmed: 16293687
J Endocr Soc. 2021 May 08;5(7):bvab088
pubmed: 34131611
Nat Rev Cardiol. 2020 Nov;17(11):698-717
pubmed: 32444692
Eur Heart J. 2005 Dec;26(24):2603-4
pubmed: 16246827
J Am Coll Cardiol. 2004 May 5;43(9):1590-5
pubmed: 15120816
Eur Heart J. 2003 Aug;24(16):1471-2
pubmed: 12919769
JACC Heart Fail. 2018 Jul;6(7):564-569
pubmed: 29501807
Cardiovasc Endocrinol Metab. 2020 May 15;9(2):49-55
pubmed: 32537565
JACC Heart Fail. 2021 Mar;9(3):192-200
pubmed: 33422435
Exp Diabesity Res. 2004 Jan-Mar;5(1):7-14
pubmed: 15198367
Circulation. 2005 Oct 4;112(14):2163-8
pubmed: 16203929
Eur Heart J. 2006 Jul;27(14):1648-50
pubmed: 16785247
J Pediatr. 1990 Jan;116(1):108-11
pubmed: 2136910
N Engl J Med. 2012 Jul 26;367(4):377-8
pubmed: 22830469
J Am Coll Cardiol. 2016 Feb 23;67(7):804-812
pubmed: 26892417
Am J Physiol. 1996 Jun;270(6 Pt 2):R1324-31
pubmed: 8764300
Clin Chem. 2005 Dec;51(12):2296-302
pubmed: 16179421
Diabet Med. 2003 Jul;20(7):535-9
pubmed: 12823233
Nat Med. 2013 May;19(5):567-75
pubmed: 23542788
JACC Heart Fail. 2015 Jul;3(7):513-519
pubmed: 26071618
Clin Med Insights Cardiol. 2013 Sep 15;7:153-9
pubmed: 24093000
Int J Cardiol. 2019 Jul 1;286:145-151
pubmed: 30878238
Am J Hum Genet. 2004 Jul;75(1):27-34
pubmed: 15146390
J Cardiovasc Med (Hagerstown). 2016 Aug;17(8):601-7
pubmed: 25252038
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
Clin Biochem. 2020 Sep;83:1-11
pubmed: 32511964
Genet Med. 2018 Jan;20(1):91-97
pubmed: 28661490
Regul Pept. 2008 Feb 7;146(1-3):204-12
pubmed: 17928074
Clin Auton Res. 1992 Oct;2(5):303-7
pubmed: 1422098
J Biol Chem. 2002 May 10;277(19):16900-5
pubmed: 11884416
N Engl J Med. 2015 Apr 23;372(17):1608-18
pubmed: 25853659
Clin Sci (Lond). 1987 Nov;73(5):489-95
pubmed: 2960480
Nat Rev Cardiol. 2014 Jul;11(7):403-12
pubmed: 24820868
J Biol Chem. 2009 Jul 17;284(29):19196-202
pubmed: 19458086
J Biol Chem. 1993 Feb 15;268(5):3698-703
pubmed: 8094083
N Engl J Med. 2008 Jul 10;359(2):158-65
pubmed: 18614783
J Biol Chem. 2019 Aug 23;294(34):12567-12578
pubmed: 31186350
J Card Fail. 2017 Aug;23(8):628-651
pubmed: 28461259
Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R310-7
pubmed: 11404307
Heart Fail Clin. 2018 Jan;14(1):27-39
pubmed: 29153198
J Am Coll Cardiol. 2021 May 11;77(18):2291-2303
pubmed: 33958126
Clin Chem. 2002 Jul;48(7):1035-42
pubmed: 12089172
Am Heart J. 2003 Jan;145(1):125-31
pubmed: 12514664
Nature. 2011 Sep 11;478(7367):103-9
pubmed: 21909115
J Am Coll Cardiol. 2012 Jul 24;60(4):277-82
pubmed: 22813603
N Engl J Med. 2002 Jul 18;347(3):161-7
pubmed: 12124404
Circulation. 2004 Feb 10;109(5):594-600
pubmed: 14769680
Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1007-16
pubmed: 20071611
PLoS One. 2016 Sep 29;11(9):e0163421
pubmed: 27684940
J Am Coll Cardiol. 2011 Mar 22;57(12):1386-95
pubmed: 21414536
Ir J Med Sci. 2005 Jul-Sep;174(3):53-7
pubmed: 16285340
Expert Opin Ther Targets. 2016 Dec;20(12):1445-1452
pubmed: 27786597
Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R612-7
pubmed: 17553844
J Am Coll Cardiol. 2007 Oct 23;50(17):1694-701
pubmed: 17950153
Physiol Rev. 2021 Oct 1;101(4):1745-1807
pubmed: 33949876
JAMA. 2009 Jan 28;301(4):383-92
pubmed: 19176440
Hypertension. 2000 Sep;36(3):355-9
pubmed: 10988264
Eur J Endocrinol. 2020 May;182(5):481-488
pubmed: 32209724
PLoS One. 2014 Jan 22;9(1):e85708
pubmed: 24465655