Secreted immune metabolites that mediate immune cell communication and function.
flux of metabolites
immune cell subsets
modification
receptor
transporter
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
28
09
2022
revised:
10
10
2022
accepted:
10
10
2022
pubmed:
9
11
2022
medline:
29
11
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
Metabolites are emerging as essential factors for the immune system that are involved in both metabolic circuits and signaling cascades. Accumulated evidence suggests that altered metabolic programs initiated by the activation and maturation of immune cell types are accompanied by the delivery of various metabolites into the local environment. We propose that, in addition to protein/peptide ligands, secreted immune metabolites (SIMets) are essential components of immune communication networks that fine-tune immune responses under homeostatic and pathological conditions. We summarize recent advances in our understanding of SIMets and discuss the potential mechanisms by which some metabolites engage in immunological responses through receptor-, transporter-, and post-translational-mediated regulation. These insights may contribute to understanding physiology and developing effective therapeutics for inflammatory and immune-mediated diseases.
Identifiants
pubmed: 36347788
pii: S1471-4906(22)00214-9
doi: 10.1016/j.it.2022.10.006
pii:
doi:
Substances chimiques
Ligands
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
990-1005Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflicts of interest.