Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children.
Children
Chinese
Epidemiology
IgA nephropathy
IgA vasculitis-associated nephritis
Kidney pathology
Treatment
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
23
01
2022
accepted:
17
10
2022
revised:
06
10
2022
medline:
4
5
2023
pubmed:
9
11
2022
entrez:
8
11
2022
Statut:
ppublish
Résumé
IgA nephropathy (IgAN) and IgA vasculitis-associated nephritis (IgAVN) are among the most frequent childhood glomerular diseases and are characterized by significant variability in clinical manifestations, pathological presentation and long-term outcomes. IgAVN, alternatively called purpura nephritis, is pathologically indistinguishable from kidney-limited IgAN. In Chinese children, the clinical presentations and pathological manifestations of IgAN and IgAVN are variable. The severity of proteinuria and abnormalities in kidney function and blood pressure of children in China are comparable to those of children in Europe, the USA, and Japan. Compared to Caucasian children and Japanese children, crescents were more common in Chinese children with IgAN or IgAVN. Approximately 10-20% of childhood IgAN or IgAVN progresses to impaired kidney function in China. Since 2007, a series of guidelines on the diagnosis and treatment of pediatric kidney diseases has been published following the principles of evidence-based medicine. However, a large difference exists between the Chinese evidence-based guidelines and the guidelines developed by Kidney Disease: Improving Global Outcomes (KDIGO) in 2021. Chinese children with IgAN or IgAVN were more likely to be treated with steroids or immunosuppressive agents. Further studies exploring the optimal treatment regimen for childhood IgAN or IgAVN are needed in the future.
Identifiants
pubmed: 36348077
doi: 10.1007/s00467-022-05798-6
pii: 10.1007/s00467-022-05798-6
pmc: PMC10154255
doi:
Substances chimiques
Immunoglobulin A
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1707-1715Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK081943
Pays : United States
Informations de copyright
© 2022. The Author(s).
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