Improvement of Low-Grade Inflammation in Patients with Metabolically Healthy Severe Obesity After Primary Bariatric Surgery.
Journal
Obesity surgery
ISSN: 1708-0428
Titre abrégé: Obes Surg
Pays: United States
ID NLM: 9106714
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
20
03
2022
accepted:
25
10
2022
revised:
16
10
2022
pubmed:
9
11
2022
medline:
14
1
2023
entrez:
8
11
2022
Statut:
ppublish
Résumé
The inflammatory state that accompanies adiposity and the metabolic syndrome (MetS) is called "low-grade" inflammation. White blood cell count (WBC) has been proposed as an emerging biomarker for predicting future cardiovascular events, MetS and mortality. Bariatric surgery (BS) improves comorbidities associated with obesity and the MetS and the surgically induced weight loss is known to improve inflammatory status. To analyze the improvement of low-grade inflammation associated to obesity in patients with metabolically healthy severe obesity (MHSO) and patients with metabolically unhealthy obesity (MUSO) (severe obesity with MetS) after primary bariatric surgery as well as the protective effect of BS against the development of MetS in patients with MHSO by reducing the WBC. Retrospective analysis of prospectively collected data of patients undergoing laparoscopic primary BS (gastric by-pass or sleeve gastrectomy) from January 2004-December 2015. Outcomes included changing of low-grade inflammation in terms of leukocytes, neutrophils, lymphocytes, and platelets. Twenty-one patients with MHSO and 167 patients with MUSO underwent laparoscopic primary BS. The preoperative values of leukocyte and platelet were statistically higher in the group of patients with MHSO. In both groups, there was significant postoperative decrease of inflammatory markers. The greatest drop in WBC occurred in the second postoperative year. No patient of the group of patients with MHSO developed MetS within five postoperative years. Surgically induced weight loss plays an important role for improvement in chronic inflammation associated to obesity because of reduction of visceral fat mass. MHSO associates a low-grade chronic inflammatory status comparable to MUSO. The improvement or decrease of low-grade inflammation in patients with metabolically healthy severe obesity after bariatric surgery could have a protective effect against the development of MetS and medical conditions associated with severe obesity.
Identifiants
pubmed: 36348177
doi: 10.1007/s11695-022-06345-w
pii: 10.1007/s11695-022-06345-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-46Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Sjöström L, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683–93. https://doi.org/10.1056/nejmoa035622 .
doi: 10.1056/nejmoa035622
Chiappetta S, et al. The impact of obesity and metabolic surgery on chronic inflammation. Obes Surg. 2018;28:3028–40. https://doi.org/10.1007/s11695-018-3320-y .
doi: 10.1007/s11695-018-3320-y
Askarpour M, Khani D, Sheikhi A, Ghaedi E, Alizadeh S. Effect of bariatric surgery on serum inflammatory factors of obese patients: a systematic review and meta-analysis. Obes Surg. 2019;29:2631–47. https://doi.org/10.1007/s11695-019-03926-0 .
doi: 10.1007/s11695-019-03926-0
Odagiri K, Uehara A, Mizuta I, Yamamoto M, Kurata C. Longitudinal study on white blood cell count and the incidence of metabolic syndrome. Intern Med. 2011;50:2491–8. https://doi.org/10.2169/internalmedicine.50.5877 .
doi: 10.2169/internalmedicine.50.5877
Babio N, et al. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study. PLoS One. 2013;8:e58354. https://doi.org/10.1371/journal.pone.0058354 .
doi: 10.1371/journal.pone.0058354
Dixon JB, O’Brien PE. Obesity and the white blood cell count: changes with sustained weight loss. Obes Surg. 2006;16:251–7. https://doi.org/10.1381/096089206776116453 .
doi: 10.1381/096089206776116453
Tsai JCR, Sheu S-H, Chiu H-C, Chung F-M, Chang D-M, Chen M-P, Shin S-J, Lee Y-J. Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2007;23:111–8. https://doi.org/10.1002/dmrr.647 .
doi: 10.1002/dmrr.647
Zimmet P, Alberti KGMM, Serrano Ríos M. Una nueva definición mundial del síndrome metabólico propuesta por la Federación Internacional de Diabetes: fundamento y resultados. Rev Española Cardiol. 2005;58:1371–6. https://www.revespcardiol.org/es-una-nueva-definicion-mundial-del-articulo-13082533 .
Hotamisligil GS. Foundations of immunometabolism and implications for metabolic health and disease. Physiol Behav. 2017;47:406–20. https://doi.org/10.1016/j.immuni.2017.08.009 .
doi: 10.1016/j.immuni.2017.08.009
De Luca M, et al. Indications for surgery for obesity and weight-related diseases: position statements from the international federation for the surgery of obesity and metabolic disorders (IFSO). Obes Surg. 2016;26:1659–96.
Minervino D, et al. Leukocyte activation in obese patients: effect of bariatric surgery. Med (United States). 2015;94:1–7. https://doi.org/10.1097/md.0000000000001382 .
doi: 10.1097/md.0000000000001382
Stefan N. Causes, consequences, and treatment of metabolically unhealthy fat distribution. Lancet Diabetes Endocrinol. 2020;8:616–27. https://doi.org/10.1016/s2213-8587(20)30110-8 .
doi: 10.1016/s2213-8587(20)30110-8
Bahadır A, et al. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anadolu Kardiyol Derg. 2015;15:816–22. https://doi.org/10.5152/akd.2014.5787 .
doi: 10.5152/akd.2014.5787
Biobaku F, Ghanim H, Monte SV, Caruana JA, Dandona P. Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects. J Endocr Soc. 2020;4:1–17. https://doi.org/10.1210/jendso/bvaa049 .
doi: 10.1210/jendso/bvaa049
Fenske WK, et al. Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study. Surg Obes Relat Dis. 2013;9:559–68. https://doi.org/10.1016/j.soard.2012.03.009 .
doi: 10.1016/j.soard.2012.03.009
Recarte M, Corripio R, De Cos AI, Vesperinas G, Díaz, and Joaquín. Low-grade systemic inflammation: gastric bypass and sleeve gastrectomy. Obes Surg. 2019;29, 347–1720: 180–181. https://doi.org/10.1007/s11695-019-04101-1
Santos J, et al. Effect of bariatric surgery on weight loss, inflammation, iron metabolism, and lipid profile. Scand J Surg. 2014;103:21–5. https://doi.org/10.1177/1457496913490467 .
doi: 10.1177/1457496913490467
Acín GD, Baltar J. Capítulo 1: Conceptos básicos. Manual del VIII Curso On-line para Residentes: Iniciación a la Cirugía Bariátrica y Metabólica. (Editor: Asociación Española de Cirujanos, 2021).
Twig G, et al. White blood cell count and the risk for coronary artery disease in young adults. PLoS ONE. 2012;7:1–8. https://doi.org/10.1371/journal.pone.0047183 .
doi: 10.1371/journal.pone.0047183
Stepanova M, Rodriguez E, Birerdinc A, Baranova A. Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity. Oncotarget. 2015;6:1414–21. https://doi.org/10.18632/oncotarget.2725 .
doi: 10.18632/oncotarget.2725
Sabench F, et al. Criterios de calidad en cirugía bariátrica: revisión de conjunto y recomendaciones de la Asociación Española de Cirujanos y de la Sociedad Española de Cirugía de la Obesidad. Cir Esp. 2017;95:4–16. https://doi.org/10.1016/j.ciresp.2016.09.007 .
doi: 10.1016/j.ciresp.2016.09.007
Chiappetta S, Stier C, Weiner RA. The Edmonton Obesity Staging System predicts perioperative complications and procedure choice in obesity and metabolic surgery—a German Nationwide Register-Based Cohort Study (StuDoQ|MBE). Obes Surg. 2019;29:3791–9. https://doi.org/10.1007/s11695-019-04015-y .
doi: 10.1007/s11695-019-04015-y