Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.

Humans alpha-Synuclein / genetics DNA, Single-Stranded Lewy Bodies Lewy Body Disease / genetics Parkinson Disease / genetics Aptamers, Nucleotide / genetics
Parkinson’s disease (PD) aptamer synucleinopathies truncated α-synuclein α-syn fibrils

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
07 12 2022
Historique:
pubmed: 10 11 2022
medline: 15 12 2022
entrez: 9 11 2022
Statut: ppublish

Résumé

Neuropathologically, Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of insoluble aggregates of α-synuclein (α-syn) in the Lewy bodies (LBs). In addition to full-length α-syn fibrils, C-terminally truncated α-syn is also abundant in the LBs that acts as seeds and facilitates the aggregation of the full-length α-syn

Identifiants

DOI: 10.1021/acschemneuro.2c00362 PMID: 36348612
pubmed: 36348612
doi: 10.1021/acschemneuro.2c00362
doi:

Substances chimiques

alpha-Synuclein 0
DNA, Single-Stranded 0
Aptamers, Nucleotide 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3330-3341

Auteurs

Issam Hmila (I)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Indulekha P Sudhakaran (IP)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Simona S Ghanem (SS)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Nishant N Vaikath (NN)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Ilaria Poggiolini (I)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Houari Abdesselem (H)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.

Omar M A El-Agnaf (OMA)

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha 34110, Qatar.
ORCID: 0000-0002-6850-8084

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN simple brin › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Cellules › Structures cellulaires › Corps d'inclusion › Corps de Lewy › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie à corps de Lewy › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Inhibition of α-Synuclein Seeding-Dependent...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Aptamères nucléotidiques › Inhibition of α-Synuclein Seeding-Dependent...