Comparison of analytical performances between clot waveform analysis and FibWave in edoxaban-treated patients and healthy controls.
activated partial thromboplastin time
anticoagulants
clot waveform analysis
edoxaban
fibrin
fibrinolysis
prothrombin time
Journal
Research and practice in thrombosis and haemostasis
ISSN: 2475-0379
Titre abrégé: Res Pract Thromb Haemost
Pays: United States
ID NLM: 101703775
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
01
04
2022
revised:
10
08
2022
accepted:
18
08
2022
entrez:
9
11
2022
pubmed:
10
11
2022
medline:
10
11
2022
Statut:
epublish
Résumé
The activated partial thromboplastin time (aPTT) and the prothrombin time (PT) are widely available coagulation parameters which are however poor predictors of the anticoagulant effect of direct oral anticoagulants (DOACs). Some coagulometers use the clot waveform analysis (CWA) to assess the clotting time but mainly based on a unique parameter. The improvement of these methodologies and the evaluation of the other waveform parameters may increase the sensitivity to DOACs. To assess the performance of an improved clot waveform an method (i.e. FibWave) to detect the impact of edoxaban on the coagulation and the fibrinolytic systems. Seventy-one samples from patients treated with edoxaban collected at minimum concentration (C PT and FibEx clotting time were strongly correlated to edoxaban concentration (Pearson FibEx is more sensitive than aPTT- and PT-based CWA for the detection of the clinically relevant anticoagulant level of edoxaban.
Identifiants
pubmed: 36349263
doi: 10.1002/rth2.12804
pii: S2475-0379(22)02443-8
pmc: PMC9634266
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12804Informations de copyright
© 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).
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