Alveolar dead space fraction is not associated with early RV systolic dysfunction in pediatric ARDS.
echocardiography
hypoxemic respiratory failure
pediatrics
respiratory dead space
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
27
10
2022
received:
12
05
2022
accepted:
04
11
2022
pmc-release:
01
02
2024
pubmed:
10
11
2022
medline:
25
1
2023
entrez:
9
11
2022
Statut:
ppublish
Résumé
We hypothesized that higher alveolar dead space fraction (AVDSf) at pediatric acute respiratory distress syndrome (PARDS) onset would be associated with right ventricular (RV) systolic dysfunction within the first 24 h of PARDS. We performed a retrospective single-center cohort study of PARDS patients with clinically obtained echocardiograms within 24 h. Primary exposure was AVDSf at PARDS onset. Primary outcome was RV systolic dysfunction as defined by RV global longitudinal strain (GLS) (>-18%). Secondary outcomes included pulmonary hypertension (PH) and RV systolic dysfunction as defined by other echocardiogram parameters, and measures of oxygenation. Unadjusted and adjusted logistic and linear regression were used to investigate AVDSf associations with outcomes. Ninety-one patients were included: median age 6.2 years, 46% female, and 65% with moderate or severe PARDS. Median AVDSf was 0.2 (interquartile range [IQR] 0.0-0.3), 33% had RV dysfunction, and 21% had PH. Unadjusted and adjusted logistic regression showed no association between AVDSf and RV systolic dysfunction or PH by any echocardiographic measure, but unadjusted and adjusted linear regression did show an association between AVDSf and PaO AVDSf at PARDS onset was not associated with RV systolic dysfunction or PH within 24 h but was associated with PaO
Identifiants
pubmed: 36349816
doi: 10.1002/ppul.26237
pmc: PMC9870940
mid: NIHMS1849587
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
559-565Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL153759
Pays : United States
Organisme : NIH HHS
ID : 1RL1HD107777-01
Pays : United States
Organisme : NIH HHS
ID : 5R01HL147616-03
Pays : United States
Organisme : NIH NHLBI
ID : 5R01HL148054-03
Organisme : NIH NHLBI
ID : 5K23-HL153759
Organisme : NIH HHS
ID : K24-HL103844
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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