Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus

Animals Mice Mycobacterium abscessus Mycobacterium tuberculosis Mycobacterium Infections, Nontuberculous / microbiology Anti-Bacterial Agents / pharmacology Microbial Sensitivity Tests
DprE1 Mycobacterium abscessus NTM OPC-167832 SigA nontuberculous mycobacteria

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
20 12 2022
Historique:
pubmed: 10 11 2022
medline: 23 12 2022
entrez: 9 11 2022
Statut: ppublish

Résumé

The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus

Identifiants

DOI: 10.1128/aac.01237-22 PMID: 36350151 PMC: PMC9765218
pubmed: 36350151
doi: 10.1128/aac.01237-22
pmc: PMC9765218
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0123722

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132374
Pays : United States

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Auteurs

Jickky Palmae Sarathy (JP)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

Matthew D Zimmerman (MD)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

Martin Gengenbacher (M)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
ORCID: 0000-0002-0208-5920

Véronique Dartois (V)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
ORCID: 0000-0001-9470-5009

Thomas Dick (T)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA.
ORCID: 0000-0002-9604-9452

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobactéries non tuberculeuses › Mycobacterium abscessus › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Infections à mycobactéries non tuberculeuses › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Mycobacterium tuberculosis DprE1 Inhibitor...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Mycobacterium tuberculosis DprE1 Inhibitor...