A Poly-ADP-Ribose Polymer-GCSF Conjugate.
Journal
Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849
Informations de publication
Date de publication:
12 Dec 2022
12 Dec 2022
Historique:
pubmed:
10
11
2022
medline:
15
12
2022
entrez:
9
11
2022
Statut:
ppublish
Résumé
Poly-ADP-ribose (PAR) is a naturally occurring form of polymers synthesized through enzymatic reactions catalyzed by poly(ADP-ribose) polymerases (PARPs). It is known for regulating various important cellular signaling pathways and processes. As a water soluble and biocompatible type of polymer, PAR may hold promise for safe and efficient delivery of therapeutics. To explore the therapeutic potential of PAR polymers, we herein generate PAR polymers conjugated with human granulocyte colony-stimulating factor (GCSF) protein by harnessing human PARP1-catalyzed auto-poly-ADP-ribosylation and a clickable analogue of nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 36350184
doi: 10.1021/acs.biomac.2c01090
pmc: PMC9772087
mid: NIHMS1849572
doi:
Substances chimiques
Poly Adenosine Diphosphate Ribose
26656-46-2
Polymers
0
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
NAD
0U46U6E8UK
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5267-5272Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB031830
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM137901
Pays : United States
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