DNA Methyltransferases and DNA Damage.
Cancer
DNA damage
DNA methylation
DNA repair
Epigenetics
Evolution
Mutation
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
9
11
2022
pubmed:
10
11
2022
medline:
15
11
2022
Statut:
ppublish
Résumé
Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation and the mechanisms for DNA repair. Additionally, recent studies have shown that DNA methyltransferases have the potential to directly introduce damage into DNA. Here, I will discuss both aspects of the connection between DNMTs and DNA damage, evaluating the potential consequences for evolution across species and in human diseases such as cancer where cellular evolution plays a key role.
Identifiants
pubmed: 36350517
doi: 10.1007/978-3-031-11454-0_14
doi:
Substances chimiques
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
DNA Modification Methylases
EC 2.1.1.-
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-361Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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