Neural correlates of eye contact and social function in autism spectrum disorder.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
03
2022
accepted:
06
10
2022
entrez:
9
11
2022
pubmed:
10
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Reluctance to make eye contact during natural interactions is a central diagnostic criterion for autism spectrum disorder (ASD). However, the underlying neural correlates for eye contacts in ASD are unknown, and diagnostic biomarkers are active areas of investigation. Here, neuroimaging, eye-tracking, and pupillometry data were acquired simultaneously using two-person functional near-infrared spectroscopy (fNIRS) during live "in-person" eye-to-eye contact and eye-gaze at a video face for typically-developed (TD) and participants with ASD to identify the neural correlates of live eye-to-eye contact in both groups. Comparisons between ASD and TD showed decreased right dorsal-parietal activity and increased right ventral temporal-parietal activity for ASD during live eye-to-eye contact (p≤0.05, FDR-corrected) and reduced cross-brain coherence consistent with atypical neural systems for live eye contact. Hypoactivity of right dorsal-parietal regions during eye contact in ASD was further associated with gold standard measures of social performance by the correlation of neural responses and individual measures of: ADOS-2, Autism Diagnostic Observation Schedule, 2nd Edition (r = -0.76, -0.92 and -0.77); and SRS-2, Social Responsiveness Scale, Second Edition (r = -0.58). The findings indicate that as categorized social ability decreases, neural responses to real eye-contact in the right dorsal parietal region also decrease consistent with a neural correlate for social characteristics in ASD.
Identifiants
pubmed: 36350848
doi: 10.1371/journal.pone.0265798
pii: PONE-D-22-06852
pmc: PMC9645655
doi:
Banques de données
Dryad
['10.5061/dryad.s4mw6m994']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0265798Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111629
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107513
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119430
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH108206
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107426
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100173
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007205
Pays : United States
Informations de copyright
Copyright: © 2022 Hirsch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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