Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.
IL-25
acetylcholine
cysteinyl leukotriene
mucociliary clearance
tuft cell
type 2 immunity
type II taste transduction
Journal
Annual review of pathology
ISSN: 1553-4014
Titre abrégé: Annu Rev Pathol
Pays: United States
ID NLM: 101275111
Informations de publication
Date de publication:
24 01 2023
24 01 2023
Historique:
pubmed:
10
11
2022
medline:
27
1
2023
entrez:
9
11
2022
Statut:
ppublish
Résumé
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summarize seminal and recent findings on tuft cells, focusing on major categories of function-instigation of type 2 cytokine responses, orchestration of antimicrobial responses, and emerging roles in tissue repair-and describe tuft cell-derived molecules used to affect these functional programs. We review what is known about the development of tuft cells from epithelial progenitors under homeostatic conditions and during disease. Finally, we discuss evidence that immature, or nascent, tuft cells with potential for diverse functions are driven toward dominant effector programs by tissue- or perturbation-specific contextual cues, which may result in heterogeneous mature tuft cell phenotypes both within and between tissues.
Identifiants
pubmed: 36351364
doi: 10.1146/annurev-pathol-042320-112212
pmc: PMC10443898
mid: NIHMS1923264
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-335Subventions
Organisme : NIDDK NIH HHS
ID : F32 DK121476
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL107202
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI026918
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL155490
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL140868
Pays : United States
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