Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.
Parkinson's disease
astrocyte
inflammation
microglia
myeloid
neurodegeneration
synuclein
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
16
10
2022
received:
29
06
2022
accepted:
21
10
2022
pubmed:
11
11
2022
medline:
25
1
2023
entrez:
10
11
2022
Statut:
ppublish
Résumé
Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro-inflammatory stimulus was different. In this study, we assessed the innate immune reaction in the midbrain and in the striatum using an experimental model of Parkinson's disease. An adeno-associated virus serotype 9 expressing the α-synuclein and mCherry genes or the mCherry gene was administered into the substantia nigra. Myeloid cells (CD11b
Identifiants
pubmed: 36353934
doi: 10.1002/glia.24295
pmc: PMC10100513
doi:
Substances chimiques
alpha-Synuclein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
571-587Subventions
Organisme : Agencia Estatal de Investigación
ID : BFU2017-90043-P
Organisme : Dirección General de Industria y Energia, Gobierno de Navarra. Proyectos Colaborativos
ID : PC 060-061
Organisme : Dirección General de Industria y Energia, Gobierno de Navarra. Proyectos Colaborativos
ID : PC 192-193
Organisme : Fundacion Gangoiti
Organisme : Instituto de Salud Carlos III-FEDER
ID : PI20/01063
Organisme : Instituto de Salud Carlos III-FEDER
ID : PI18/00556
Organisme : LB was funded by the Ministerio de Universidades
Organisme : LA was funded by the Ministerio de Universidades
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. GLIA published by Wiley Periodicals LLC.
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