Low Release Study of Cefotaxime by Functionalized Mesoporous Silica Nanomaterials.
MCM-41
cefotaxime
low release
mesoporous material
sol–gel
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
03 Nov 2022
03 Nov 2022
Historique:
received:
04
10
2022
revised:
24
10
2022
accepted:
02
11
2022
entrez:
10
11
2022
pubmed:
11
11
2022
medline:
11
11
2022
Statut:
epublish
Résumé
As a third-generation β-lactam antibiotic, cefotaxime shows a broad-spectrum with Gram-positive and Gram-negative bacteria activity and is included in WHO's essential drug list. In order to obtain new materials with sustained release properties, the present research focuses on the study of cefotaxime absorption and desorption from different functionalized mesoporous silica supports. The MCM-41-type nanostructured mesoporous silica support was synthesized by sol-gel technique using a tetraethyl orthosilicate (TEOS) route and cetyltrimethylammonium bromide (CTAB) as a surfactant, at room temperature and normal pressure. The obtained mesoporous material (MCM-41 class) was characterized through nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), N
Identifiants
pubmed: 36354619
pii: gels8110711
doi: 10.3390/gels8110711
pmc: PMC9689901
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : BIOMATE
ID : PN-III-P4-ID-PCE-2016-0884 / 2017
Organisme : PROZECHIMED
ID : PN-III-P2-2.1-PTE-2016-0160, 49-PTE / 2016
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