A Review of the Safety of Interleukin-17A Inhibitor Secukinumab.
adverse event
inflammatory bowel disease
interleukin 17
psoriasis
secukinumab
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
07 Nov 2022
07 Nov 2022
Historique:
received:
15
09
2022
revised:
28
10
2022
accepted:
02
11
2022
entrez:
10
11
2022
pubmed:
11
11
2022
medline:
11
11
2022
Statut:
epublish
Résumé
Secukinumab is an anti-interleukin (IL)-17A IgG1-κ monoclonal antibody approved for psoriasis, psoriatic arthritis, and ankylosing spondylitis. Its efficacy is well documented, but the complete safety profile of secukinumab, especially on long-term use, needs to be studied. IL-17 inhibitors increase the risk of infections, especially respiratory tract infections and candidiasis, and inflammatory bowel disease; the causal relationships are well described. However, evidence regarding the other adverse events is scarce, and causal associations between the adverse events and the biologic remain unresolved. This review aims to present a narrative perspective on the safety of secukinumab and identify some key areas where the safety of secukinumab may potentially be useful in understanding the scope of secukinumab therapy and making informed clinical decisions.
Identifiants
pubmed: 36355537
pii: ph15111365
doi: 10.3390/ph15111365
pmc: PMC9695424
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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