SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
23 12 2022
Historique:
pubmed: 11 11 2022
medline: 28 12 2022
entrez: 10 11 2022
Statut: ppublish

Résumé

Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S

Identifiants

pubmed: 36356052
doi: 10.1126/sciimmunol.adf1421
pmc: PMC9765460
doi:

Substances chimiques

Antibodies, Viral 0
Antibodies, Neutralizing 0
COVID-19 Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadf1421

Subventions

Organisme : NIAID NIH HHS
ID : R25 AI147376
Pays : United States
Organisme : NIAID NIH HHS
ID : DP1 AI158186
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93022C00036
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120553
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151698
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142742
Pays : United States

Commentaires et corrections

Type : UpdateOf

Auteurs

John E Bowen (JE)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Young-Jun Park (YJ)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Cameron Stewart (C)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Jack T Brown (JT)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

William K Sharkey (WK)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Alexandra C Walls (AC)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Anshu Joshi (A)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Kaitlin R Sprouse (KR)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Matthew McCallum (M)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

M Alejandra Tortorici (MA)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Nicholas M Franko (NM)

Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.

Jennifer K Logue (JK)

Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.

Ignacio G Mazzitelli (IG)

Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina.

Annalee W Nguyen (AW)

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Rui P Silva (RP)

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Yimin Huang (Y)

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Jun Siong Low (JS)

Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.

Josipa Jerak (J)

Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.

Sasha W Tiles (SW)

Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

Kumail Ahmed (K)

Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.

Asefa Shariq (A)

Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.

Jennifer M Dan (JM)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA.

Zeli Zhang (Z)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA.

Daniela Weiskopf (D)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA.

Alessandro Sette (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA.

Gyorgy Snell (G)

Vir Biotechnology, San Francisco, CA 94158, USA.

Christine M Posavad (CM)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Najeeha Talat Iqbal (NT)

Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.

Jorge Geffner (J)

Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina.

Alessandra Bandera (A)

Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Andrea Gori (A)

Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Federica Sallusto (F)

Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.

Jennifer A Maynard (JA)

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Shane Crotty (S)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA.

Wesley C Van Voorhis (WC)

Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

Carlos Simmerling (C)

Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.
Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA.

Renata Grifantini (R)

INGM, Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi," 20122 Milan, Italy.

Helen Y Chu (HY)

Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.

Davide Corti (D)

Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.

David Veesler (D)

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

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Classifications MeSH