Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness.
aging
immunosenescence
obesity
physical activity
physical fitness
sex
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
27 Oct 2022
27 Oct 2022
Historique:
received:
22
09
2022
revised:
21
10
2022
accepted:
25
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Cardiorespiratory fitness (CRF) is essential for sustained work ability in good health, but declines with aging, as does the functionality of the immune system, the latter process commonly referred to as immunosenescence. This study aimed to compare the capacity of immunosenescence biomarkers with chronological age for predicting low CRF in a cross-sectional sample recruited from the regional working population. CRF was determined by submaximal bicycle ergometer testing in a cross-sectional sample of 597 volunteers aged 20-70 years from the 'Dortmund Vital Study' (DVS, ClinicalTrials.gov Identifier: NCT05155397). Low CRF was scored if the ergometer test was not completed due to medical reasons or if the power output projected to a heart rate of 130 bpm divided by body mass was below sex-specific reference values of 1.25 W/kg for females and 1.5 W/kg for males, respectively. In addition to established biomarkers of immunosenescence, we calibrated a comprehensive metric of immune age to our data and compared its predictive capacity for low CRF to chronological age, while adjusting our analysis for the influence of sex, obesity, and the level of regular physical activity, by applying univariate and multiple logistic regression. While obesity, low physical activity, chronological and immune age were all associated with increased probability for low CRF in univariate analyses, multiple logistic regression revealed that obesity and physical activity together with immune age, but not chronological age, were statistically significant predictors of low CRF outcome. Sex was non-significant due to the applied sex-specific reference values. These results demonstrate that biological age assessed by our immunological metric can outperform chronological age as a predictor for CRF and indicate a potential role for immunosenescence in explaining the inter-individual variability of the age-related decline in cardiorespiratory fitness.
Identifiants
pubmed: 36358277
pii: biology11111576
doi: 10.3390/biology11111576
pmc: PMC9687950
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT05155397']
Types de publication
Journal Article
Langues
eng
Références
Int J Occup Med Environ Health. 2017 Oct 18;31(1):1-9
pubmed: 28765667
Nat Aging. 2021 Jul;1:598-615
pubmed: 34888528
Immun Ageing. 2022 Jul 20;19(1):33
pubmed: 35858901
J Sport Health Sci. 2019 May;8(3):201-217
pubmed: 31193280
Nat Med. 2019 Mar;25(3):487-495
pubmed: 30842675
Neuropsychologia. 2015 Jul;73:195-207
pubmed: 25937323
Sci Rep. 2020 Jan 16;10(1):445
pubmed: 31949174
Immun Ageing. 2012 Jul 25;9(1):15
pubmed: 22830639
Brain Stimul. 2021 May-Jun;14(3):622-634
pubmed: 33798763
Psychol Methods. 2006 Mar;11(1):54-71
pubmed: 16594767
Int J Environ Res Public Health. 2021 Feb 10;18(4):
pubmed: 33578976
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 May;56(5-6):885-93
pubmed: 23703510
Mayo Clin Proc. 2022 Feb;97(2):285-293
pubmed: 34809986
Nat Rev Immunol. 2019 Sep;19(9):563-572
pubmed: 31175337
Immun Ageing. 2013 May 15;10(1):19
pubmed: 23675689
Int J Mol Sci. 2019 Jun 08;20(11):
pubmed: 31181772
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
J Prev Alzheimers Dis. 2020;7(1):56-64
pubmed: 32010927
Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C879-C884
pubmed: 35912994
Nat Rev Genet. 2022 Dec;23(12):715-727
pubmed: 35715611
J Am Coll Cardiol. 2018 Nov 6;72(19):2283-2292
pubmed: 30384883
Arch Toxicol. 2016 Oct;90(10):2481-95
pubmed: 27522652
J Occup Environ Med. 2000 Sep;42(9):906-10
pubmed: 10998766
J Occup Rehabil. 2011 Jun;21(2):275-85
pubmed: 21052807
Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):306-14
pubmed: 25269064
BMC Sports Sci Med Rehabil. 2021 Dec 14;13(1):156
pubmed: 34906224
BMC Public Health. 2020 Jan 8;20(1):22
pubmed: 31914965
World Health Organ Tech Rep Ser. 1995;854:1-452
pubmed: 8594834
JMIRx Med. 2022 May 24;3(2):e32935
pubmed: 35969709
Semin Immunopathol. 2020 Oct;42(5):559-572
pubmed: 33165716
Annu Rev Cell Dev Biol. 2020 Oct 6;36:551-574
pubmed: 33021823
Eur Heart J. 2021 Sep 7;42(34):3404-3406
pubmed: 34379742
JMIR Form Res. 2023 May 19;7:e40818
pubmed: 37204831
J Immunol. 2015 May 1;194(9):4073-80
pubmed: 25888703
Semin Cell Dev Biol. 2021 Aug;116:180-193
pubmed: 33509689
Front Immunol. 2020 Nov 11;11:585168
pubmed: 33262764
Nat Med. 2019 Dec;25(12):1822-1832
pubmed: 31806905
Biogerontology. 2008 Oct;9(5):299-308
pubmed: 18369735
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
N Engl J Med. 2020 Aug 27;383(9):804-805
pubmed: 32302079
Semin Immunopathol. 2020 Oct;42(5):537-544
pubmed: 32757035
Scand J Public Health. 2021 Mar;49(2):206-218
pubmed: 32515284
Phys Ther. 2000 Aug;80(8):782-807
pubmed: 10911416
Blood. 2000 May 1;95(9):2860-8
pubmed: 10779432
Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S422-S428
pubmed: 28005419
Circulation. 2013 Aug 20;128(8):873-934
pubmed: 23877260
Am J Ind Med. 2008 Aug;51(8):610-25
pubmed: 18543279
Appl Physiol Nutr Metab. 2016 Jun;41(6 Suppl 2):S92-S107
pubmed: 27277571
Aging (Albany NY). 2021 May 26;13(10):13443-13459
pubmed: 34038386
Int J Methods Psychiatr Res. 2018 Dec;27(4):e1614
pubmed: 29691917
JAMA. 1989 Nov 3;262(17):2395-401
pubmed: 2795824
JMIR Res Protoc. 2022 Mar 14;11(3):e32352
pubmed: 35285810
Eur J Epidemiol. 2021 Jul;36(7):753-762
pubmed: 34117979
Immun Ageing. 2021 Jan 18;18(1):5
pubmed: 33461563
Nat Med. 2020 Jan;26(1):83-90
pubmed: 31932806
Exp Gerontol. 2004 Apr;39(4):539-44
pubmed: 15050288
PLoS One. 2013 Sep 04;8(9):e74539
pubmed: 24023949
Brain Behav Immun. 2011 Nov;25(8):1521-9
pubmed: 21784146
J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74
pubmed: 23213031
Curr Atheroscler Rep. 2018 Jan 16;20(1):1
pubmed: 29340805
Exp Gerontol. 2018 May;105:4-9
pubmed: 29111233
Age Ageing. 2022 Jun 1;51(6):
pubmed: 35737600
Gesundheitswesen. 2021 Feb;83(2):114-121
pubmed: 31746446
Immunology. 2007 Apr;120(4):435-46
pubmed: 17313487
Lancet Public Health. 2019 Jul;4(7):e316-e317
pubmed: 31204285