DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.

SARS-CoV-2 gastrointestinal tract metabolomics transcriptomics viral infection

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
03 Nov 2022
Historique:
received: 04 10 2022
revised: 24 10 2022
accepted: 28 10 2022
entrez: 11 11 2022
pubmed: 12 11 2022
medline: 12 11 2022
Statut: epublish

Résumé

Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nucleic acids with high affinity and directly interact with double stranded RNA, which plays a key role in viral replication.

Identifiants

pubmed: 36358551
pii: antiox11112177
doi: 10.3390/antiox11112177
pmc: PMC9686780
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI20/01090
Organisme : Instituto de Salud Carlos III
ID : CP18/00009
Organisme : Instituto de Salud Carlos III
ID : CM19/00190
Organisme : Fundació Marató de TV3
ID : 201612-31
Organisme : Marie Skłodowska-Curie Innovative Training Network
ID : 859890

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Auteurs

Ángela Del Castillo-Izquierdo (Á)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.

José María Moreno-Navarrete (JM)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.

Jessica Latorre (J)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.

María Arnoriaga-Rodríguez (M)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.

Marta Ballanti (M)

Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Center for Atherosclerosis, Policlinico Tor Vergata, 00133 Rome, Italy.

Giovanni Monteleone (G)

Center for Atherosclerosis, Policlinico Tor Vergata, 00133 Rome, Italy.

Omero Alessandro Paoluzi (O)

Center for Atherosclerosis, Policlinico Tor Vergata, 00133 Rome, Italy.

Geltrude Mingrone (G)

Department of Internal Medicine, Catholic University, 00168 Rome, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Diabetes and Nutritional Sciences, Hodgkin Building, Guy's Campus, King's College London, London WC2R 2LS, UK.

Josep Puig (J)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.
Department of Radiology (IDI), Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain.

Rafael Ramos (R)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.
Vascular Health Research Group of Girona (ISV-Girona), Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain.
Primary Care Services, Catalan Institute of Health (ICS), 17007 Girona, Spain.

Josep Garre-Olmo (J)

Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.
Vascular Health Research Group of Girona (ISV-Girona), Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08007 Barcelona, Spain.

Mariona Jové (M)

Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), 25198 Lleida, Spain.

Reinald Pamplona (R)

Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), 25198 Lleida, Spain.

Manuel Portero-Otín (M)

Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), 25198 Lleida, Spain.

Joaquim Sol (J)

Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), 25198 Lleida, Spain.

Philippe Lefebvre (P)

Institut Pasteur de Lille, Université Lille, Inserm, CHU Lille, F-59000 Lille, France.

Bart Staels (B)

Institut Pasteur de Lille, Université Lille, Inserm, CHU Lille, F-59000 Lille, France.

Massimo Federici (M)

Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Center for Atherosclerosis, Policlinico Tor Vergata, 00133 Rome, Italy.

José Manuel Fernández-Real (JM)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, 17004 Girona, Spain.

Jordi Mayneris-Perxachs (J)

Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, 17007 Girona, Spain.
Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Classifications MeSH