Looking into Endoplasmic Reticulum Stress: The Key to Drug-Resistance of Multiple Myeloma?
drug resistance
endoplasmic reticulum stress
multiple myeloma
unfolded protein response
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Oct 2022
29 Oct 2022
Historique:
received:
30
09
2022
revised:
21
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Multiple myeloma (MM) is the second most common hematologic malignancy, resulting from the clonal proliferation of malignant plasma cells within the bone marrow. Despite significant advances that have been made with novel drugs over the past two decades, MM patients often develop therapy resistance, especially to bortezomib, the first-in-class proteasome inhibitor that was approved for treatment of MM. As highly secretory monoclonal protein-producing cells, MM cells are characterized by uploaded endoplasmic reticulum stress (ERS), and rely heavily on the ERS response for survival. Great efforts have been made to illustrate how MM cells adapt to therapeutic stresses through modulating the ERS response. In this review, we summarize current knowledge on the mechanisms by which ERS response pathways influence MM cell fate and response to treatment. Moreover, based on promising results obtained in preclinical studies, we discuss the prospect of applying ERS modulators to overcome drug resistance in MM.
Identifiants
pubmed: 36358759
pii: cancers14215340
doi: 10.3390/cancers14215340
pmc: PMC9654020
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 81974007
Organisme : National Natural Science Foundation of China
ID : 81700206
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