Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells.
amplitude modulation
anticancer effects
colorectal cancer
hyperthermia
radiofrequency
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Oct 2022
30 Oct 2022
Historique:
received:
02
08
2022
revised:
12
10
2022
accepted:
21
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Non-temperature-induced effects of radiofrequency electromagnetic fields (RF) have been controversial for decades. Here, we established measurement techniques to prove their existence by investigating energy deposition in tumor cells under RF exposure and upon adding amplitude modulation (AM) (AMRF). Using a preclinical device LabEHY-200 with a novel in vitro applicator, we analyzed the power deposition and system parameters for five human colorectal cancer cell lines and measured the apoptosis rates in vitro and tumor growth inhibition in vivo in comparison to water bath heating. We showed enhanced anticancer effects of RF and AMRF in vitro and in vivo and verified the non-temperature-induced origin of the effects. Furthermore, apoptotic enhancement by AM was correlated with cell membrane stiffness. Our findings not only provide a strategy to significantly enhance non-temperature-induced anticancer cell effects in vitro and in vivo but also provide a perspective for a potentially more effective tumor therapy.
Identifiants
pubmed: 36358768
pii: cancers14215349
doi: 10.3390/cancers14215349
pmc: PMC9655505
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Berliner Krebsgesellschaft
ID : GHFF202006
Organisme : H2020 Marie Sklodowska-Curie program - HYPERBOOST
ID : 955625
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