Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma.
glioblastoma
medicinal chemistry
microtubule-associated protein Tau
signaling pathway
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Nov 2022
01 Nov 2022
Historique:
received:
24
09
2022
revised:
28
10
2022
accepted:
28
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Despite being extensively studied for several decades, the microtubule-associated protein Tau has not finished revealing its secrets. For long, Tau has been known for its ability to promote microtubule assembly. A less known feature of Tau is its capability to bind to cancer-related protein kinases, suggesting a possible role of Tau in modulating microtubule-independent cellular pathways that are associated with oncogenesis. With the intention of finding new therapeutic targets for cancer, it appears essential to examine the interaction of Tau with these kinases and their consequences. This review aims at collecting the literature data supporting the relationship between Tau and cancer with a particular focus on glioblastoma tumors in which the pathological significance of Tau remains largely unexplored. We will first treat this subject from a mechanistic point of view showing the pivotal role of Tau in oncogenic processes. Then, we will discuss the involvement of Tau in dysregulating critical pathways in glioblastoma. Finally, we will outline promising strategies to target Tau protein for the therapy of glioblastoma.
Identifiants
pubmed: 36358803
pii: cancers14215386
doi: 10.3390/cancers14215386
pmc: PMC9653627
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nat Neurosci. 2014 Mar;17(3):357-66
pubmed: 24464041
Int J Mol Sci. 2020 Sep 28;21(19):
pubmed: 32998341
Leukemia. 2007 Jan;21(1):44-52
pubmed: 16990761
J Biol Chem. 2000 May 26;275(21):15733-40
pubmed: 10747907
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8315-20
pubmed: 15914550
J Cell Biol. 2003 Jan 20;160(2):171-5
pubmed: 12527748
Eur J Med Chem. 2022 Feb 5;229:114090
pubmed: 34992037
J Clin Neurosci. 2009 Jun;16(6):748-54
pubmed: 19324552
Int J Biochem Cell Biol. 2004 Dec;36(12):2420-34
pubmed: 15325582
Methods Mol Biol. 2012;849:85-99
pubmed: 22528085
Neuron. 2003 May 22;38(4):555-65
pubmed: 12765608
Oncogene. 2019 Mar;38(10):1734-1750
pubmed: 30353164
Neuroscience. 2004;127(3):649-58
pubmed: 15283964
J Neurochem. 2002 Oct;83(1):176-85
pubmed: 12358741
Oncogene. 2000 Nov 20;19(49):5620-35
pubmed: 11114743
Front Oncol. 2020 Dec 08;10:604121
pubmed: 33364198
J Biol Chem. 2008 Dec 26;283(52):36406-15
pubmed: 18940799
BMC Cell Biol. 2009 Nov 08;10:81
pubmed: 19895707
Neurotherapeutics. 2013 Jul;10(3):486-97
pubmed: 23686823
Neuro Oncol. 2020 Jun 9;22(6):806-818
pubmed: 31950181
J Alzheimers Dis. 2013;33(4):969-82
pubmed: 23047372
J Biol Chem. 2002 Apr 5;277(14):11933-40
pubmed: 11812770
J Exp Clin Cancer Res. 2020 Jul 18;39(1):138
pubmed: 32682428
Cell Cycle. 2005 Sep;4(9):1149-52
pubmed: 16103753
Nat Chem Biol. 2008 Aug;4(8):483-90
pubmed: 18587388
Cancer Med. 2019 Feb;8(2):783-794
pubmed: 30656845
J Neuroimmune Pharmacol. 2016 Mar;11(1):9-25
pubmed: 26538351
J Cell Biol. 1985 Dec;101(6):2095-103
pubmed: 3934177
Biochemistry. 2020 Dec 8;59(48):4546-4562
pubmed: 33237772
Hum Mutat. 2000;16(2):109-22
pubmed: 10923032
J Mol Biol. 1977 Oct 25;116(2):207-25
pubmed: 599557
Signal Transduct Target Ther. 2020 Jul 2;5(1):113
pubmed: 32616710
J Cyst Fibros. 2022 May;21(3):529-536
pubmed: 34961705
J Biol Chem. 2010 Jul 16;285(29):21978-87
pubmed: 20466727
Eur J Med Chem. 2017 Jan 5;125:464-477
pubmed: 27689729
Anticancer Res. 2015 Oct;35(10):5179-84
pubmed: 26408675
Int J Alzheimers Dis. 2012;2012:578373
pubmed: 22675648
J Neurochem. 2008 Sep;106(5):2119-30
pubmed: 18636984
Curr Med Sci. 2020 Feb;40(1):1-8
pubmed: 32166659
J Neurochem. 2004 Oct;91(2):299-307
pubmed: 15447663
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1289-E1298
pubmed: 29358399
Sci Transl Med. 2020 Jan 22;12(527):
pubmed: 31969485
Cell. 1997 Apr 18;89(2):297-308
pubmed: 9108484
Sci Transl Med. 2017 Jan 25;9(374):
pubmed: 28123067
Int J Oncol. 2018 Mar;52(3):787-803
pubmed: 29328367
Sci Transl Med. 2019 Mar 27;11(485):
pubmed: 30918111
J Biol Chem. 2013 Nov 15;288(46):33081-95
pubmed: 24089520
PLoS One. 2015 Feb 06;10(2):e0117511
pubmed: 25659102
Brain Res Bull. 2011 May 30;85(3-4):194-200
pubmed: 21435383
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):341-358
pubmed: 28694093
Nat Rev Drug Discov. 2022 May 30;:
pubmed: 35637317
Oncotarget. 2021 Feb 16;12(4):304-315
pubmed: 33659042
Brain Sci. 2020 Nov 16;10(11):
pubmed: 33207722
Annu Rev Cell Dev Biol. 1997;13:513-609
pubmed: 9442882
Cell Death Differ. 2006 Jul;13(7):1238-41
pubmed: 16456578
Neurochem Int. 2011 Mar;58(4):458-71
pubmed: 21215781
Mol Neurodegener. 2016 Aug 30;11(1):62
pubmed: 27578006
Neuron. 1989 Apr;2(4):1389-97
pubmed: 2560640
Biosci Rep. 2020 Jun 26;40(6):
pubmed: 32484210
Cancer Res. 2017 Nov 15;77(22):6190-6201
pubmed: 29021135
PLoS One. 2009 Oct 13;4(10):e7443
pubmed: 19823589
J Clin Oncol. 2009 Sep 10;27(26):4287-92
pubmed: 19667268
Cancer Res. 2004 Sep 15;64(18):6503-10
pubmed: 15374961
Cancer Cell. 2010 Jan 19;17(1):98-110
pubmed: 20129251
Cancers (Basel). 2020 Dec 31;13(1):
pubmed: 33396266
Curr Alzheimer Res. 2014;11(10):918-27
pubmed: 25387336
J Biol Chem. 2011 Feb 11;286(6):4566-75
pubmed: 21131359
Br J Cancer. 2006 Jun 19;94(12):1894-7
pubmed: 16721363
Pathol Int. 2020 Jan;70(1):40-46
pubmed: 31855307
Neurobiol Dis. 2020 Dec;146:105130
pubmed: 33065281
Science. 1997 Mar 28;275(5308):1943-7
pubmed: 9072974
Cancer Res. 2008 Aug 15;68(16):6643-51
pubmed: 18701488
Nature. 1976 Mar 11;260(5547):170-3
pubmed: 176594
Pharmacol Rep. 2021 Feb;73(1):227-239
pubmed: 33140310
Cell Rep. 2018 May 8;23(6):1651-1664
pubmed: 29742423
Acta Neuropathol Commun. 2020 Aug 18;8(1):137
pubmed: 32811565
Proteomics Clin Appl. 2009 Jun;3(6):743-53
pubmed: 21136983
Cancer Cell. 2008 Mar;13(3):235-48
pubmed: 18328427
Neuro Oncol. 2008 Oct;10(5):690-9
pubmed: 18715951
Biochem J. 2004 Aug 15;382(Pt 1):1-11
pubmed: 15193142
J Cell Biochem. 2009 Oct 15;108(3):555-64
pubmed: 19681044
Cell. 1996 Aug 9;86(3):353-64
pubmed: 8756718
J Cancer Res Clin Oncol. 2021 Jul;147(7):1957-1971
pubmed: 33811272
J Biol Chem. 2008 Jun 27;283(26):18177-86
pubmed: 18467332
J Biol Chem. 2004 Dec 31;279(53):54983-6
pubmed: 15525651
Biomolecules. 2016 Jan 07;6(1):9
pubmed: 26751496
Methods Mol Biol. 2017;1523:61-85
pubmed: 27975244
Drugs. 2021 Jul;81(10):1135-1152
pubmed: 34101156
Front Cell Neurosci. 2014 Mar 18;8:84
pubmed: 24672431
J Cancer. 2021 May 10;12(13):3958-3966
pubmed: 34093802
Mol Cytogenet. 2014 Mar 06;7(1):20
pubmed: 24602248
Acta Neuropathol. 1993;86(3):236-41
pubmed: 8213081
J Cell Sci. 2013 Jul 1;126(Pt 13):2810-9
pubmed: 23659998
Prog Neurobiol. 2013 Jun;105:49-59
pubmed: 23528736
Int J Mol Sci. 2021 Feb 12;22(4):
pubmed: 33673213
J Biol Chem. 2004 Aug 13;279(33):34873-81
pubmed: 15190058
Cancer Res. 2005 Jul 1;65(13):5535-43
pubmed: 15994925
FEBS Lett. 1992 Dec 21;314(3):315-21
pubmed: 1334849
J Med Chem. 2018 Sep 13;61(17):7640-7656
pubmed: 30078314
FASEB J. 2015 Oct;29(10):4133-44
pubmed: 26103986
Angew Chem Int Ed Engl. 2013 Mar 18;52(12):3511-5
pubmed: 23401175
J Biol Chem. 2004 Jun 18;279(25):26105-14
pubmed: 15073173
J Biol Chem. 1985 Apr 10;260(7):4016-20
pubmed: 3920212
Cell Cycle. 2003 Nov-Dec;2(6):517-20
pubmed: 14504464
J Biol Chem. 1982 Aug 10;257(15):9143-51
pubmed: 6124545
Res Rep Urol. 2017 May 08;9:71-77
pubmed: 28507979
Neuron. 2010 Sep 23;67(6):953-66
pubmed: 20869593
J Biol Chem. 2005 Oct 21;280(42):35119-25
pubmed: 16115884
J Neurochem. 2005 Apr;93(1):105-17
pubmed: 15773910
Pharmacol Rep. 2021 Feb;73(1):211-226
pubmed: 33030673
Nature. 2018 Aug;560(7717):253-257
pubmed: 30069049
Neurobiol Aging. 1995 May-Jun;16(3):479-86
pubmed: 7566354
Biochem Soc Trans. 2019 Apr 30;47(2):625-638
pubmed: 30902924
Dev Dyn. 2019 Jan;248(1):53-64
pubmed: 30091290
Oncogene. 2007 May 14;26(22):3291-310
pubmed: 17496923
Oncogene. 2007 Aug 13;26(37):5310-8
pubmed: 17694074
J Nanobiotechnology. 2022 Sep 15;20(1):412
pubmed: 36109754
Pathol Oncol Res. 2013 Jul;19(3):429-35
pubmed: 23446558
Signal Transduct Target Ther. 2017 Sep 29;2:17040
pubmed: 29263927
J Mol Biol. 1977 Oct 25;116(2):227-47
pubmed: 146092
Cancers (Basel). 2020 Jun 12;12(6):
pubmed: 32545574
Mol Cell. 2001 Aug;8(2):317-25
pubmed: 11545734
Front Aging Neurosci. 2021 Jan 28;12:630743
pubmed: 33633561
J Neuropathol Exp Neurol. 2020 May 1;79(5):493-499
pubmed: 32181806
Am J Transl Res. 2021 Jun 15;13(6):6055-6065
pubmed: 34306344
J Cell Biol. 1994 Mar;124(5):769-82
pubmed: 8120098
Mol Biol Cell. 2004 Jun;15(6):2720-8
pubmed: 15020716
Front Psychiatry. 2011 Oct 21;2:59
pubmed: 22025915
Acta Neuropathol. 2016 May;131(5):737-52
pubmed: 26988843
Trends Biochem Sci. 1992 Dec;17(12):498-501
pubmed: 1471260
J Biol Chem. 1991 May 5;266(13):8108-14
pubmed: 1850737
J Agric Food Chem. 2020 Feb 19;68(7):2054-2062
pubmed: 31995984
Biochim Biophys Acta. 2003 Feb 21;1645(2):205-11
pubmed: 12573250
J Neurol Sci. 2018 Aug 15;391:90-99
pubmed: 30103978
J Cell Biol. 1986 Dec;103(6 Pt 2):2739-46
pubmed: 3098742
Urol Oncol. 2020 Oct;38(10):795.e1-795.e8
pubmed: 32430253
Brain Pathol. 1993 Jan;3(1):87-95
pubmed: 7903586
J Biol Chem. 2016 Apr 8;291(15):8173-88
pubmed: 26861879
Sci Rep. 2016 Sep 06;6:32972
pubmed: 27595933
Cell Death Dis. 2021 Apr 7;12(4):374
pubmed: 33828082
Cell. 2000 Oct 13;103(2):211-25
pubmed: 11057895
Mol Cancer Ther. 2021 Sep;20(9):1672-1679
pubmed: 34158343
Acta Neuropathol Commun. 2019 Feb 15;7(1):22
pubmed: 30767766
FEBS Lett. 2006 Oct 30;580(25):5925-33
pubmed: 17045592
Nat Rev Drug Discov. 2014 Aug;13(8):588-602
pubmed: 25033736
Biochemistry. 1994 Aug 16;33(32):9511-22
pubmed: 8068626
Int J Oncol. 2012 Sep;41(3):1029-35
pubmed: 22752145
J Exp Clin Cancer Res. 2013 Apr 30;32:25
pubmed: 23631819
BMC Cancer. 2019 Mar 1;19(1):193
pubmed: 30823906
Cancer Discov. 2018 Sep;8(9):1096-1111
pubmed: 29903880
Expert Rev Neurother. 2007 Nov;7(11):1527-33
pubmed: 17997701
Oncotarget. 2016 May 31;7(22):31955-71
pubmed: 27049916
Nat Rev Neurol. 2018 Jul;14(7):399-415
pubmed: 29895964
Prog Neurobiol. 2018 Sep;168:104-127
pubmed: 29733887
World J Surg Oncol. 2015 Jul 25;13:223
pubmed: 26205145
Oncogene. 2007 May 14;26(22):3279-90
pubmed: 17496922
J Clin Oncol. 2016 Sep 1;34(25):3105-7
pubmed: 27298401
EMBO J. 1989 Feb;8(2):393-9
pubmed: 2498079
Autophagy. 2012 Nov;8(11):1686-7
pubmed: 22874558
J Biol Chem. 2000 Aug 18;275(33):25247-54
pubmed: 10840038
J Cell Sci. 1997 May;110 ( Pt 10):1251-60
pubmed: 9191048
Nature. 1984 Nov 15-21;312(5991):237-42
pubmed: 6504138
Med Oncol. 2013 Jun;30(2):526
pubmed: 23475578
Nat Commun. 2021 Apr 14;12(1):2238
pubmed: 33854069
Cancer Res. 2009 Dec 15;69(24):9157-9
pubmed: 19996293
Nature. 1994 Feb 10;367(6463):572-6
pubmed: 7509042
Neurosci Lett. 1992 Nov 23;147(1):58-62
pubmed: 1336152
Front Mol Neurosci. 2020 Oct 16;13:586731
pubmed: 33177989
Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10369-73
pubmed: 7479786
Cell. 2013 Oct 10;155(2):462-77
pubmed: 24120142
Hum Mol Genet. 2004 Apr 1;13(7):703-14
pubmed: 14962978
Bull Cancer. 2013 Jul-Aug;100(7-8):715-26
pubmed: 23831947
Neurotherapeutics. 2020 Jul;17(3):1087-1103
pubmed: 32096091
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18567-71
pubmed: 19017796
J Biol Chem. 1994 Sep 30;269(39):24290-7
pubmed: 7929085
J Alzheimers Dis. 2019;71(2):631-645
pubmed: 31424392
Clin Transl Sci. 2020 Nov;13(6):1178-1188
pubmed: 32738099
Cancer Lett. 2010 Dec 8;298(2):139-49
pubmed: 20947248
J Cell Sci. 2019 Feb 11;132(3):
pubmed: 30659115
Biochemistry. 2015 Feb 24;54(7):1525-33
pubmed: 25623359
Exp Neurol. 1994 Apr;126(2):185-94
pubmed: 7925819
EMBO J. 1990 Dec;9(13):4225-30
pubmed: 2124967
J Cell Sci. 1996 Jun;109 ( Pt 6):1537-43
pubmed: 8799840
Nat Cell Biol. 2000 Oct;2(10):709-17
pubmed: 11025661
Exp Cell Res. 1995 Oct;220(2):332-7
pubmed: 7556441
Brain Res Dev Brain Res. 1989 Oct 1;49(2):305-10
pubmed: 2572361
Cells. 2019 Sep 18;8(9):
pubmed: 31540455
BMC Cancer. 2021 Sep 15;21(1):1025
pubmed: 34525976
Cell. 1993 Mar 26;72(6):945-52
pubmed: 7681364
J Biol Chem. 2000 Dec 8;275(49):38182-9
pubmed: 10984497
Oncogene. 2004 Oct 18;23(48):7906-9
pubmed: 15489908
J Biol Chem. 2003 Apr 11;278(15):12722-8
pubmed: 12551948
Ann Oncol. 2014 Sep;25 Suppl 3:iii93-101
pubmed: 24782454
Cell Death Dis. 2019 Apr 11;10(4):322
pubmed: 30975980
Oncotarget. 2015 Mar 20;6(8):6326-40
pubmed: 25811972
Cancer Res. 2006 Jan 1;66(1):473-81
pubmed: 16397263
Mol Cancer Ther. 2020 Jul;19(7):1415-1422
pubmed: 32430486
Cytokine Growth Factor Rev. 2021 Jun;59:71-83
pubmed: 33727011
FASEB J. 2006 Jun;20(8):1272-4
pubmed: 16645045
FEBS Lett. 2002 Jul 17;523(1-3):247-51
pubmed: 12123840
Cancer Res. 2009 Sep 1;69(17):6889-98
pubmed: 19690143
FASEB J. 2006 Jul;20(9):1452-61
pubmed: 16816120
Neurooncol Adv. 2021 Sep 17;3(1):vdab133
pubmed: 34806012
J Cell Sci. 1998 Nov;111 ( Pt 21):3167-77
pubmed: 9763511
Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-5028
pubmed: 27624076
J Neurosci. 1996 Sep 15;16(18):5583-92
pubmed: 8795614
Dis Model Mech. 2016 Mar;9(3):307-19
pubmed: 26822478
Antioxid Redox Signal. 2014 Jan 20;20(3):460-73
pubmed: 23725295
Chromosoma. 1996 Jul;105(1):20-30
pubmed: 8662255
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8
pubmed: 9990064
Trends Mol Med. 2015 Jun;21(6):394-402
pubmed: 25846560
Cancer Chemother Pharmacol. 2010 May;65(6):1009-21
pubmed: 20130877
Hum Vaccin Immunother. 2018 Feb 1;14(2):277-284
pubmed: 29049003
Curr Biol. 2001 Jul 10;11(13):R502
pubmed: 11470419
Cancer Res. 1991 Apr 15;51(8):2212-22
pubmed: 2009540
Aging Cell. 2014 Apr;13(2):379-90
pubmed: 24341874
Int J Cell Biol. 2012;2012:930710
pubmed: 22675363
Int J Dev Neurosci. 2012 Oct;30(6):411-9
pubmed: 22906543
Mol Biosyst. 2016 Oct 18;12(11):3417-3424
pubmed: 27714074
J Cell Sci. 1992 Jun;102 ( Pt 2):227-37
pubmed: 1400630
Neuron. 1989 Oct;3(4):519-26
pubmed: 2484340
J Neurosci. 2002 Dec 15;22(24):10621-6
pubmed: 12486154
Mol Biol Cell. 1995 Oct;6(10):1397-410
pubmed: 8573794
Pharmacol Ther. 2015 Aug;152:63-82
pubmed: 25944528
Blood. 2010 Jun 10;115(23):4824-33
pubmed: 20348394
Adv Sci (Weinh). 2020 Mar 12;7(9):1902971
pubmed: 32382477
Mol Neurodegener. 2015 Mar 26;10:14
pubmed: 25881209
PLoS One. 2013 Aug 02;8(8):e70804
pubmed: 23936469
J Biol Chem. 2015 Aug 28;290(35):21652-62
pubmed: 26126828
Sci Rep. 2015 Jun 09;5:11161
pubmed: 26057852
FEBS J. 2021 Sep 12;:
pubmed: 34510775
Exp Mol Med. 2018 Apr 6;50(4):1-11
pubmed: 29622771
Neurobiol Dis. 2009 May;34(2):212-20
pubmed: 19344645
Cell Motil Cytoskeleton. 1995;30(3):194-207
pubmed: 7758136
Front Mol Neurosci. 2019 Oct 15;12:242
pubmed: 31749682
Cell Signal. 2012 Jan;24(1):44-52
pubmed: 21924349
Neurobiol Dis. 2015 Oct;82:540-551
pubmed: 26385829
Adv Exp Med Biol. 2017;1002:93-124
pubmed: 28600784
Mol Neurobiol. 2019 Jan;56(1):406-434
pubmed: 29705945
Front Aging Neurosci. 2016 Nov 08;8:262
pubmed: 27877124
Ann Transl Med. 2015 Jun;3(10):135
pubmed: 26207228
Cell Motil Cytoskeleton. 1994;29(2):117-30
pubmed: 7820862
FEBS Lett. 1987 Jun 15;217(2):237-41
pubmed: 3109941
Biochemistry. 1983 Apr 26;22(9):2186-92
pubmed: 6860659
Cancers (Basel). 2021 Nov 19;13(22):
pubmed: 34830972
Proc Natl Acad Sci U S A. 1975 May;72(5):1858-62
pubmed: 1057175
Neurobiol Dis. 2012 Apr;46(1):101-8
pubmed: 22249108
Carcinogenesis. 2015 Jun;36 Suppl 1:S61-88
pubmed: 26106144
Biochim Biophys Acta. 2005 Jan 3;1739(2-3):268-79
pubmed: 15615645
Oncogene. 1993 Jun;8(6):1429-36
pubmed: 8502471
J Neural Transm (Vienna). 2005 Jun;112(6):813-38
pubmed: 15517432
J Biol Chem. 2004 Nov 26;279(48):50078-88
pubmed: 15375165
Nature. 2008 Oct 23;455(7216):1061-8
pubmed: 18772890
Int J Mol Sci. 2020 Jan 30;21(3):
pubmed: 32019137
Int J Mol Sci. 2014 Aug 21;15(8):14697-714
pubmed: 25196605
Neuropharmacology. 2014 Oct;85:121-30
pubmed: 24880087
J Biol Chem. 2010 Nov 12;285(46):35932-43
pubmed: 20826806
Blood. 2017 Mar 30;129(13):1876-1878
pubmed: 28126927
Cancer Discov. 2017 May;7(5):462-477
pubmed: 28331002
Brain Sci. 2017 Dec 20;7(12):
pubmed: 29261148
J Neurochem. 2000 Apr;74(4):1469-77
pubmed: 10737603
Cancer Cell. 2006 Mar;9(3):157-73
pubmed: 16530701
Cancers (Basel). 2018 Sep 01;10(9):
pubmed: 30200436
J Cell Sci. 2007 Mar 1;120(Pt 5):748-57
pubmed: 17284520
Proc Natl Acad Sci U S A. 1990 Nov;87(21):8422-6
pubmed: 1700432
J Biol Chem. 2010 May 28;285(22):16798-805
pubmed: 20308058
Aging Cell. 2020 Feb;19(2):e13069
pubmed: 31858697
Commun Biol. 2020 May 19;3(1):245
pubmed: 32427887
J Clin Neurosci. 2020 Aug;78:400-402
pubmed: 32340843
Neuropharmacology. 2020 Sep 15;175:108104
pubmed: 32360477
Neuropsychiatr Dis Treat. 2015 Apr 09;11:1015-30
pubmed: 25914534
J Cell Biol. 1984 Jul;99(1 Pt 2):33s-37s
pubmed: 6430911
Nat Commun. 2015 Oct 27;6:8620
pubmed: 26503418
Autophagy. 2010 Jan;6(1):182-3
pubmed: 20023429
Front Aging Neurosci. 2019 Aug 07;11:204
pubmed: 31447664
Mol Cancer Ther. 2010 Nov;9(11):2970-81
pubmed: 21062914
FEBS Lett. 1995 Jan 16;358(1):4-8
pubmed: 7821426
Cell Div. 2015 May 20;10:3
pubmed: 26015801
Biochem Soc Trans. 2012 Aug;40(4):644-52
pubmed: 22817709
Clin Cancer Res. 2009 Feb 1;15(3):887-97
pubmed: 19188159
Oncogene. 2018 Mar;37(12):1561-1575
pubmed: 29321659
Cell Mol Neurobiol. 2008 May;28(3):351-69
pubmed: 18183483
Nat Cell Biol. 2003 Aug;5(8):701-10
pubmed: 12855954
Nat Commun. 2019 Jan 16;10(1):228
pubmed: 30651536
J Histochem Cytochem. 1991 Jul;39(7):899-904
pubmed: 1865106
Nat Rev Cancer. 2003 Jun;3(6):401-10
pubmed: 12778130
Biochem Biophys Res Commun. 2021 May 21;554:206-213
pubmed: 33813076
J Clin Oncol. 2016 Mar 1;34(7):731-9
pubmed: 26786929
Nat Rev Cancer. 2004 Apr;4(4):253-65
pubmed: 15057285
Aging Dis. 2017 May 2;8(3):257-266
pubmed: 28580182
Int J Oncol. 2014 May;44(5):1736-44
pubmed: 24585004
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579
pubmed: 28049840
Nat Rev Neurosci. 2011 Feb;12(2):65-72
pubmed: 21193853
Oncol Lett. 2017 Dec;14(6):6597-6603
pubmed: 29151909
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3895-900
pubmed: 23431171
Ann N Y Acad Sci. 1986;466:803-12
pubmed: 3460455
J Cell Biochem. 2002;85(2):315-24
pubmed: 11948687
FEBS Lett. 2006 May 29;580(13):3121-8
pubmed: 16684527
Mol Neurodegener. 2017 May 18;12(1):39
pubmed: 28521765
J Clin Invest. 2017 Jun 1;127(6):2081-2090
pubmed: 28504649
Cancer Med. 2020 Oct;9(19):7352-7359
pubmed: 32794373
Cell. 1997 Feb 21;88(4):435-7
pubmed: 9038334
J Neurosci. 2007 Jun 27;27(26):6859-67
pubmed: 17596434
J Cell Biochem. 2000 May;78(2):305-17
pubmed: 10842324
Int J Mol Sci. 2021 Jul 30;22(15):
pubmed: 34360973
J Neurooncol. 2006 May;78(1):19-29
pubmed: 16552622
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5
pubmed: 11035810
Brain Pathol. 1999 Jul;9(3):469-79
pubmed: 10416987
Eur J Gynaecol Oncol. 2011;32(5):496-9
pubmed: 22053660
Acta Neuropathol Commun. 2020 Aug 10;8(1):132
pubmed: 32778161
Int J Alzheimers Dis. 2012;2012:731526
pubmed: 22690349
Aging Cell. 2018 Feb;17(1):
pubmed: 29024336
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
J Cell Biol. 1978 Sep;78(3):958-65
pubmed: 568144
Cell Commun Signal. 2019 Jul 17;17(1):76
pubmed: 31315632
Hum Genet. 1997 Dec;101(3):299-305
pubmed: 9439658
Biochemistry. 2006 Mar 14;45(10):3134-45
pubmed: 16519508
Curr Biol. 1998 Oct 22;8(21):1169-78
pubmed: 9799734
Mol Pharmacol. 2006 May;69(5):1527-33
pubmed: 16436588
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13298-302
pubmed: 14593208
Biochemistry. 2013 Sep 17;52(37):6445-55
pubmed: 23962087
Nature. 2006 May 25;441(7092):437-43
pubmed: 16724055