Organoids for Modeling (Colorectal) Cancer in a Dish.
CRISPR/Cas9 gene editing
cancer stem cells
intratumoral heterogeneity
organoids
personalized precision medicine
predictive in vitro models
tumor immune microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Nov 2022
03 Nov 2022
Historique:
received:
21
09
2022
revised:
21
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Functional studies of primary cancer have been limited to animal models for a long time making it difficult to study aspects specific to human cancer biology. The development of organoid technology enabled us to culture human healthy and tumor cells as three-dimensional self-organizing structures in vitro for a prolonged time. Organoid cultures conserve the heterogeneity of the originating epithelium regarding cell types and tumor clonality. Therefore, organoids are considered an invaluable tool to study and genetically dissect various aspects of human cancer biology. In this review, we describe the applications, advantages, and limitations of organoids as human cancer models with the main emphasis on colorectal cancer.
Identifiants
pubmed: 36358834
pii: cancers14215416
doi: 10.3390/cancers14215416
pmc: PMC9655999
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : FWF Austrian Science Fund
ID : W1213
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