Orthostatic Challenge-Induced Coagulation Activation in Young and Older Persons.
aging
clot formation
orthostatic challenge
thrombelastometry
thrombin generation
thrombosis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
31 Oct 2022
31 Oct 2022
Historique:
received:
27
09
2022
revised:
14
10
2022
accepted:
29
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
The incidence of thrombosis increases with aging. We investigated the coagulatory/haemostatic system across the ages and tested the hypothesis that older persons have a hypercoagulable state compared to younger persons at rest, and that standing up (orthostasis) leads to greater changes in coagulation in older persons. In total, 22 older and 20 young participants performed a 6 min sit-to-stand test (orthostatic challenge). Blood was collected prior to and at the end of standing and haemostatic profiling was performed via thrombelastometry (TEM), calibrated automated thrombogram (CAT) and standard coagulation assays. At baseline, three CAT-derived values indicated enhanced capability to generate thrombin in older participants. However, other measured parameters did not suggest a hypercoagulable state in older participants: prolonged TEM-derived coagulation times (295 vs. 209 s, medians,
Identifiants
pubmed: 36359289
pii: biomedicines10112769
doi: 10.3390/biomedicines10112769
pmc: PMC9687232
pii:
doi:
Types de publication
Journal Article
Langues
eng
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