Emerging Role of YAP and the Hippo Pathway in Prostate Cancer.
Hippo pathway
YAP
YAP/TAZ signaling
prostate cancer
prostate cancer hallmarks
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
07 Nov 2022
07 Nov 2022
Historique:
received:
15
09
2022
revised:
13
10
2022
accepted:
02
11
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
The Hippo pathway regulates and contributes to several hallmarks of prostate cancer (PCa). Although the elucidation of YAP function in PCa is in its infancy, emerging studies have shed light on the role of aberrant Hippo pathway signaling in PCa development and progression. YAP overexpression and nuclear localization has been linked to poor prognosis and resistance to treatment, highlighting a therapeutic potential that may suggest innovative strategies to treat cancer. This review aimed to summarize available data on the biological function of the dysregulated Hippo pathway in PCa and identify knowledge gaps that need to be addressed for optimizing the development of YAP-targeted treatment strategies in patients likely to benefit.
Identifiants
pubmed: 36359354
pii: biomedicines10112834
doi: 10.3390/biomedicines10112834
pmc: PMC9687800
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Curr Biol. 2010 Jul 13;20(13):R574-82
pubmed: 20619814
FEBS J. 2006 Sep;273(18):4264-76
pubmed: 16930133
FEBS Open Bio. 2015 Jun 22;5:542-9
pubmed: 26199863
Mod Pathol. 2015 Nov;28(11):1492-503
pubmed: 26381823
Oncogene. 1994 Aug;9(8):2145-52
pubmed: 8035999
Nat Cell Biol. 2003 Oct;5(10):914-20
pubmed: 14502294
Prostate. 2008 Jun 15;68(9):975-84
pubmed: 18361411
J Immunol Res. 2014;2014:261365
pubmed: 24860833
Nat Rev Cancer. 2007 Mar;7(3):182-91
pubmed: 17318211
Nat Cell Biol. 2003 Oct;5(10):921-7
pubmed: 14502295
Oncogene. 2005 Mar 17;24(12):2076-86
pubmed: 15688006
Cell. 2014 Jul 3;158(1):157-70
pubmed: 24976009
Clin Cancer Res. 2018 Jun 15;24(12):2732-2739
pubmed: 29559559
Sci Transl Med. 2021 Jun 30;13(600):
pubmed: 34193613
Nat Cell Biol. 2015 Sep;17(9):1218-27
pubmed: 26258633
Genes Dev. 2010 Feb 1;24(3):290-300
pubmed: 20123908
Genes Dev. 1995 Mar 1;9(5):534-46
pubmed: 7698644
Nat Commun. 2017 Jan 18;8:14122
pubmed: 28098159
Cell. 2012 Aug 17;150(4):780-91
pubmed: 22863277
Tumori. 2015 Mar-Apr;101(2):189-93
pubmed: 25908048
J Biol Chem. 1995 Jun 16;270(24):14733-41
pubmed: 7782338
Dev Biol. 2010 Jan 15;337(2):303-12
pubmed: 19900439
Cell. 2013 Sep 12;154(6):1342-55
pubmed: 24012335
Clin Cancer Res. 2015 Jan 15;21(2):357-64
pubmed: 25388162
BMB Rep. 2018 Mar;51(3):143-150
pubmed: 29366444
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18034-9
pubmed: 16332960
FASEB J. 2019 Nov;33(11):12487-12499
pubmed: 31431076
Clin Cancer Res. 2002 Aug;8(8):2530-5
pubmed: 12171880
Oncogene. 2021 Apr;40(13):2407-2421
pubmed: 33664454
Trends Biochem Sci. 2021 Feb;46(2):154-168
pubmed: 32981815
Anticancer Res. 2012 Sep;32(9):3827-34
pubmed: 22993325
Can Urol Assoc J. 2016 Nov-Dec;10(11-12):E414-E423
pubmed: 28096932
Cancers (Basel). 2021 Apr 12;13(8):
pubmed: 33921222
Genes Dev. 2013 Feb 15;27(4):355-71
pubmed: 23431053
J Neuropathol Exp Neurol. 2015 Jul;74(7):704-9
pubmed: 26049897
Cancer Discov. 2016 Jan;6(1):80-95
pubmed: 26701088
Sci Rep. 2016 Aug 24;6:31842
pubmed: 27555231
Mol Cell Biol. 2015 Apr;35(8):1350-62
pubmed: 25645929
Biochem J. 2004 Jul 15;381(Pt 2):453-62
pubmed: 15109305
ACS Med Chem Lett. 2014 Jul 14;5(9):993-8
pubmed: 25221655
Mol Med Rep. 2015 Oct;12(4):4867-76
pubmed: 26126522
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E89-98
pubmed: 24367099
Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2569-74
pubmed: 23359693
J Neuropathol Exp Neurol. 2015 Oct;74(10):952-9
pubmed: 26360373
Front Biosci (Landmark Ed). 2012 Jan 01;17(1):331-48
pubmed: 22201747
J Biol Chem. 2017 Jun 2;292(22):9420-9430
pubmed: 28408625
Genes Dev. 2001 May 15;15(10):1229-41
pubmed: 11358867
Oncotarget. 2017 Dec 7;8(70):115054-115067
pubmed: 29383141
Cancers (Basel). 2020 Jan 19;12(1):
pubmed: 31963871
Genes Dev. 2020 Aug 1;34(15-16):1051-1064
pubmed: 32675324
Theranostics. 2021 Mar 31;11(12):5794-5812
pubmed: 33897882
Nat Commun. 2021 Jul 6;12(1):4147
pubmed: 34230470
Genes Dev. 2010 May;24(9):862-74
pubmed: 20439427
Cell Div. 2016 Mar 31;11:4
pubmed: 27042197
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
J Biol Chem. 2018 Jul 13;293(28):11230-11240
pubmed: 29802201
Nat Rev Cancer. 2015 Feb;15(2):73-79
pubmed: 25592648
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12405-10
pubmed: 16894141
Acta Neuropathol. 2020 Jan;139(1):215-218
pubmed: 31734728
Nature. 2013 Jan 3;493(7430):106-10
pubmed: 23178811
Biol Cell. 2002 Oct;94(6):305-13
pubmed: 12500938
Cell Discov. 2015 Nov 24;1:15038
pubmed: 27462435
Cancer Cell. 2014 Feb 10;25(2):166-80
pubmed: 24525233
Carcinogenesis. 2011 Mar;32(3):389-98
pubmed: 21112960
Cell Metab. 2018 Aug 7;28(2):196-206
pubmed: 30089241
Nat Commun. 2015 Oct 05;6:8357
pubmed: 26437443
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
BMC Cancer. 2020 Apr 15;20(1):302
pubmed: 32293349
Curr Biol. 2018 May 21;28(10):1651-1660.e4
pubmed: 29754899
Development. 2020 Apr 27;147(8):
pubmed: 32341025
Oncogene. 2019 Mar;38(12):2192-2205
pubmed: 30467379
Oncogene. 2016 Mar 24;35(12):1541-53
pubmed: 26119935
Oncogene. 2015 Feb 5;34(6):681-90
pubmed: 24531710
Nat Rev Mol Cell Biol. 2014 Apr;15(4):225-42
pubmed: 24651541
J Exp Clin Cancer Res. 2021 Jul 24;40(1):241
pubmed: 34303383
Genes Cells. 2009 May;14(5):607-15
pubmed: 19371381
Oncogene. 2022 Feb;41(6):757-769
pubmed: 34845375
Dev Cell. 2015 Sep 28;34(6):642-55
pubmed: 26364751
Science. 2012 Dec 14;338(6113):1465-9
pubmed: 23239736
Oncogene. 2008 Nov 24;27(55):6888-907
pubmed: 19029932
Mol Cancer Ther. 2021 Jun;20(6):986-998
pubmed: 33850002
Cancer Cell. 2012 Nov 13;22(5):601-14
pubmed: 23153534
J Clin Invest. 2011 Nov;121(11):4257-67
pubmed: 21965329
Adv Sci (Weinh). 2020 Jun 17;7(15):1903583
pubmed: 32775149
Genes Dev. 2007 Nov 1;21(21):2747-61
pubmed: 17974916
J Biol Chem. 2020 Nov 20;295(47):16166-16179
pubmed: 32994222
Mol Cancer. 2018 Sep 3;17(1):134
pubmed: 30176928
Int J Mol Sci. 2013 Jan 15;14(1):1684-97
pubmed: 23322019
Physiol Rev. 2014 Oct;94(4):1287-312
pubmed: 25287865
Exp Biol Med (Maywood). 2021 Apr;246(8):888-896
pubmed: 33307801
Cancer Cell. 2015 Jun 8;27(6):797-808
pubmed: 26058078
Sci Rep. 2020 Jun 2;10(1):8916
pubmed: 32488048
Genes Dev. 2008 Jul 15;22(14):1962-71
pubmed: 18579750
Dev Cell. 2011 Nov 15;21(5):896-906
pubmed: 22075148
Dev Cell. 2008 Mar;14(3):388-98
pubmed: 18258486
J Exp Clin Cancer Res. 2017 Oct 10;36(1):139
pubmed: 29017577
Nat Cell Biol. 2015 Apr;17(4):490-9
pubmed: 25751139
Cell. 2015 Nov 5;163(4):811-28
pubmed: 26544935
EMBO Rep. 2014 Jun;15(6):642-56
pubmed: 24825474
Dev Dyn. 2009 Jul;238(7):1627-37
pubmed: 19517570
Cancer Cell. 2016 Jun 13;29(6):783-803
pubmed: 27300434
Nat Commun. 2015 Sep 01;6:8126
pubmed: 28230103
EMBO J. 2014 Mar 3;33(5):468-81
pubmed: 24497554
Trends Biochem Sci. 2010 Nov;35(11):627-33
pubmed: 20598891
J Clin Invest. 2019 May 30;129(9):3827-3832
pubmed: 31145701
Biochem J. 2013 Oct 1;455(1):1-14
pubmed: 24028161
Mol Cell Biol. 2008 Apr;28(7):2426-36
pubmed: 18227151
Genes Dev. 2012 Jan 1;26(1):54-68
pubmed: 22215811
Cell. 2005 Aug 12;122(3):421-34
pubmed: 16096061
Cell Res. 2013 Oct;23(10):1201-14
pubmed: 23999857
Oncogene. 2020 May;39(20):4014-4027
pubmed: 32205868
Genes Dev. 2012 Jun 15;26(12):1300-5
pubmed: 22677547
Neoplasia. 2008 Feb;10(2):177-88
pubmed: 18283340
Genes Dev. 2003 Oct 15;17(20):2514-9
pubmed: 14561774
Curr Biol. 2008 Mar 25;18(6):435-41
pubmed: 18313299
Trends Cell Biol. 2010 Jul;20(7):410-7
pubmed: 20452772
Endocrinology. 2010 Nov;151(11):5136-45
pubmed: 20881251
PLoS One. 2015 Aug 11;10(8):e0135119
pubmed: 26263504
Oncogene. 2017 Mar 2;36(9):1232-1244
pubmed: 27546622
Signal Transduct Target Ther. 2021 Jul 12;6(1):263
pubmed: 34248142
Cell. 2002 Aug 23;110(4):467-78
pubmed: 12202036
Cell. 2005 Mar 11;120(5):675-85
pubmed: 15766530
Clin Cancer Res. 2011 Apr 15;17(8):2130-9
pubmed: 21346147
Science. 2005 Oct 28;310(5748):644-8
pubmed: 16254181
Cancer Biol Med. 2017 Nov;14(4):405-413
pubmed: 29372107
Front Cell Dev Biol. 2019 Apr 10;7:49
pubmed: 31024911
PLoS One. 2013 Jun 10;8(6):e65539
pubmed: 23762387
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Development. 2014 Apr;141(8):1614-26
pubmed: 24715453
PLoS One. 2014 Jun 27;9(6):e100974
pubmed: 24972085
Cell Stem Cell. 2016 Dec 1;19(6):725-737
pubmed: 27641305
J Clin Invest. 2016 Feb;126(2):706-20
pubmed: 26731476
FEBS Lett. 2010 Oct 8;584(19):4175-80
pubmed: 20850437
N Engl J Med. 2015 Oct 29;373(18):1697-708
pubmed: 26510020
Nat Commun. 2019 Sep 2;10(1):3914
pubmed: 31477715
Oncol Rep. 2017 May;37(5):2620-2632
pubmed: 28339095
Invest New Drugs. 2018 Apr;36(2):278-287
pubmed: 29250742
BMC Cancer. 2020 Oct 29;20(1):1042
pubmed: 33121449
Nucleic Acids Res. 2020 Jun 4;48(10):5366-5382
pubmed: 32324216
Dev Cell. 2010 Jul 20;19(1):27-38
pubmed: 20643348
Front Cell Dev Biol. 2021 May 24;9:673599
pubmed: 34109179
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):108-115
pubmed: 33506898
Eur J Cancer. 2019 May;112:118-126
pubmed: 30850323
Gut. 2018 Sep;67(9):1692-1703
pubmed: 28866620
Dev Cell. 2019 Aug 5;50(3):264-282
pubmed: 31386861
Clin Cancer Res. 2014 Sep 1;20(17):4660-72
pubmed: 24951773