Physical Exercise Promotes DNase Activity Enhancing the Capacity to Degrade Neutrophil Extracellular Traps.
DNase activity
cardiovascular diseases
cardiovascular health
neutrophil extracellular traps
physical exercise
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
08 Nov 2022
08 Nov 2022
Historique:
received:
29
09
2022
revised:
24
10
2022
accepted:
29
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
(1) Background: An unhealthy lifestyle is a significant contributor to the development of chronic diseases. Physical activity can benefit primary and secondary prevention. Higher DNase activity is associated with favourable outcomes after cardiovascular (CV) events. In this study, we aimed to investigate the influence of consequent endurance exercise on DNase activity. (2) Methods: 98 subjects with at least one CV risk factor but the physical ability to perform endurance training were included. Individuals performed a bicycle stress test at the beginning and after 8 months to assess physical performance. In between, all participants were instructed to engage in guideline-directed physical activity. Blood samples were drawn in two-month intervals to assess routine laboratory parameters, cell-free DNA (cfDNA), and DNase activity. (3) Results: Prevailing CV risk factors were overweight (65.9%), a positive family history (44.9%), hypertension (32.7%) and smoking (20.4%). Performance changed by 7.8 ± 9.1% after 8 months. Comparison of baseline to 8 months revealed a decrease in cfDNA and an increase in DNase activity. This effect was driven by participants who achieved a performance gain. (4) Conclusions: Regular physical activity might improve CV health by increasing DNase activity and thereby, the capacity to lower pro-inflammatory signalling, complementing measures of primary and secondary prevention.
Identifiants
pubmed: 36359376
pii: biomedicines10112849
doi: 10.3390/biomedicines10112849
pmc: PMC9717727
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FWF Austrian Science Fund
ID : W 1205-B09
Références
Clin Biochem. 2014 Apr;47(6):471-4
pubmed: 24373926
J Immunol. 2011 Jul 1;187(1):538-52
pubmed: 21613614
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Circ Res. 2015 Mar 27;116(7):1182-92
pubmed: 25547404
J Appl Physiol (1985). 2014 Aug 1;117(3):325-33
pubmed: 24833781
Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):
pubmed: 28507196
Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):2598-2615
pubmed: 34348488
Nat Genet. 2000 Jun;25(2):177-81
pubmed: 10835632
Eur J Clin Invest. 2021 Nov;51(11):e13595
pubmed: 34101826
Int J Sports Physiol Perform. 2017 May;12(5):597-604
pubmed: 27617485
Transl Res. 2021 Jul;233:32-46
pubmed: 33571683
Nat Genet. 2011 Oct 23;43(12):1186-8
pubmed: 22019780
Int J Sports Physiol Perform. 2018 Aug 1;13(7):953-956
pubmed: 29182414
Heart Vessels. 2018 Aug;33(8):893-900
pubmed: 29368166
Cochrane Database Syst Rev. 2018 Sep 06;9:CD001127
pubmed: 30187450
JCI Insight. 2021 Sep 22;6(18):
pubmed: 34324440
PLoS One. 2018 Jan 25;13(1):e0191915
pubmed: 29370268
Science. 2017 Dec 1;358(6367):1202-1206
pubmed: 29191910
J Immunol. 2020 Apr 15;204(8):2088-2097
pubmed: 32188756
PLoS One. 2012;7(2):e32366
pubmed: 22389696
Med Sci Sports Exerc. 2013 Feb;45(2):238-44
pubmed: 22903136
Resuscitation. 2020 Jun;151:26-32
pubmed: 32251701
J Extracell Vesicles. 2022 Mar;11(3):e12205
pubmed: 35289089
J Clin Endocrinol Metab. 2005 Jul;90(7):3914-8
pubmed: 15855262
Front Immunol. 2021 Mar 04;12:613597
pubmed: 33746957
Circ Res. 2020 Apr 24;126(9):1228-1241
pubmed: 32324499
Sports Med. 2002;32(8):489-509
pubmed: 12076176
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
Heart Vessels. 2016 Oct;31(10):1603-8
pubmed: 26661073
Br J Sports Med. 1994 Dec;28(4):247-55
pubmed: 7894956
Natl Vital Stat Rep. 2021 May;70(4):1-115
pubmed: 34029179
Lancet. 2016 Oct 8;388(10053):1659-1724
pubmed: 27733284
JAMA. 2022 May 10;327(18):1771-1781
pubmed: 35368058
Sports Med. 2012 Jul 1;42(7):565-86
pubmed: 22694348
PLoS One. 2018 Feb 23;13(2):e0191150
pubmed: 29474368
Exerc Immunol Rev. 2011;17:6-63
pubmed: 21446352
Br J Sports Med. 2020 Dec;54(24):1451-1462
pubmed: 33239350
Exerc Immunol Rev. 2011;17:64-103
pubmed: 21446353
Mol Ther Nucleic Acids. 2020 Jun 5;20:50-61
pubmed: 32146418
JAMA. 2021 May 11;325(18):1829-1830
pubmed: 33787821
Science. 2015 Jul 17;349(6245):316-20
pubmed: 26185250
Nature. 2019 May;569(7755):236-240
pubmed: 31043745
Mol Biol Rep. 2021 May;48(5):4625-4635
pubmed: 34014471
Clin Chem. 2004 Sep;50(9):1668-70
pubmed: 15331502
J Sports Sci. 2017 Nov;35(21):2129-2134
pubmed: 27858577
Lancet. 2006 May 27;367(9524):1747-57
pubmed: 16731270
J Clin Med. 2020 Jun 17;9(6):
pubmed: 32560548
Int J Environ Res Public Health. 2022 Jul 16;19(14):
pubmed: 35886510
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L586-96
pubmed: 25085626
Biochem J. 2004 Jun 15;380(Pt 3):929-37
pubmed: 15015938
Sports Med. 2015 May;45(5):625-40
pubmed: 25504501
Basic Res Cardiol. 2021 Apr 23;116(1):29
pubmed: 33891165
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5
pubmed: 20798043
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):988-994
pubmed: 33267662