Mitoferrin, Cellular and Mitochondrial Iron Homeostasis.
cancer
erythropoiesis
iron
mitochondria
mitoferrin
oxidative stress
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 11 2022
02 11 2022
Historique:
received:
22
09
2022
revised:
28
10
2022
accepted:
29
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Iron is essential for many cellular processes, but cellular iron homeostasis must be maintained to ensure the balance of cellular signaling processes and prevent disease. Iron transport in and out of the cell and cellular organelles is crucial in this regard. The transport of iron into the mitochondria is particularly important, as heme and the majority of iron-sulfur clusters are synthesized in this organelle. Iron is also required for the production of mitochondrial complexes that contain these iron-sulfur clusters and heme. As the principal iron importers in the mitochondria of human cells, the mitoferrins have emerged as critical regulators of cytosolic and mitochondrial iron homeostasis. Here, we review the discovery and structure of the mitoferrins, as well as the significance of these proteins in maintaining cytosolic and mitochondrial iron homeostasis for the prevention of cancer and many other diseases.
Identifiants
pubmed: 36359860
pii: cells11213464
doi: 10.3390/cells11213464
pmc: PMC9658796
pii:
doi:
Substances chimiques
Heme
42VZT0U6YR
Iron
E1UOL152H7
Sulfur
70FD1KFU70
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS093663
Pays : United States
Organisme : NIH HHS
ID : U01 NS093663
Pays : United States
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