GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway.
GDNF
IPSC
electrophysiology
epilepsy
ret
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2022
29 Oct 2022
Historique:
received:
28
09
2022
revised:
26
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Glial cell line-derived neurotrophic factor (GDNF) has been shown to counteract seizures when overexpressed or delivered into the brain in various animal models of epileptogenesis or chronic epilepsy. The mechanisms underlying this effect have not been investigated. We here demonstrate for the first time that GDNF enhances GABAergic inhibitory drive onto mouse pyramidal neurons by modulating postsynaptic GABA
Identifiants
pubmed: 36361981
pii: ijms232113190
doi: 10.3390/ijms232113190
pmc: PMC9653719
pii:
doi:
Substances chimiques
Glial Cell Line-Derived Neurotrophic Factor
0
Glial Cell Line-Derived Neurotrophic Factor Receptors
0
Proto-Oncogene Proteins c-ret
EC 2.7.10.1
RET protein, human
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Stiftelsen Olle Engkvist Byggmästare
ID : 2016/319
Organisme : Hjärnfonden
ID : FO2021-0312
Organisme : Alzheimer's Research UK
ID : ARUK-EG2019B-003
Organisme : Landshövding Per Westlings Minnesfond
ID : 95096/RFh2019-0067
Organisme : LU Innovation
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