Highly Charged Ru(II) Polypyridyl Complexes as Photosensitizer Agents in Photodynamic Therapy of Epithelial Ovarian Cancer Cells.
Humans
Female
Photosensitizing Agents
/ pharmacology
Photochemotherapy
Ruthenium
/ pharmacology
Carcinoma, Ovarian Epithelial
/ drug therapy
Cell Line, Tumor
Reactive Oxygen Species
HeLa Cells
Ovarian Neoplasms
/ drug therapy
Neoplasm Recurrence, Local
Coordination Complexes
/ pharmacology
Antineoplastic Agents
/ pharmacology
coordination complexes
drug discovery
phototoxicity
reactive oxygen species
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Nov 2022
01 Nov 2022
Historique:
received:
27
09
2022
revised:
22
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Ovarian cancer recurrence is frequent and associated with chemoresistance, leading to extremely poor prognosis. Herein, we explored the potential anti-cancer effect of a series of highly charged Ru(II)-polypyridyl complexes as photosensitizers in photodynamic therapy (PDT), which were able to efficiently sensitize the formation of singlet oxygen upon irradiation (
Identifiants
pubmed: 36362089
pii: ijms232113302
doi: 10.3390/ijms232113302
pmc: PMC9655950
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Ruthenium
7UI0TKC3U5
Reactive Oxygen Species
0
Coordination Complexes
0
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Chemistry. 2019 Aug 9;25(45):10606-10615
pubmed: 31107567
Molecules. 2015 Jan 27;20(2):2115-37
pubmed: 25633337
Photodiagnosis Photodyn Ther. 2004 Dec;1(4):279-93
pubmed: 25048432
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Free Radic Biol Med. 2021 Aug 1;171:69-79
pubmed: 33957221
Future Oncol. 2015;11(23):3187-95
pubmed: 26551891
ChemMedChem. 2018 Oct 22;13(20):2229-2239
pubmed: 30157309
Biochem Biophys Res Commun. 2012 Jul 13;423(4):819-25
pubmed: 22713472
J Control Release. 2011 Dec 20;156(3):276-80
pubmed: 21888934
JAMA. 2011 Jun 8;305(22):2295-303
pubmed: 21642681
Sci Rep. 2019 Jul 16;9(1):10320
pubmed: 31311943
Molecules. 2021 Jan 20;26(3):
pubmed: 33498435
Chem Soc Rev. 2017 Dec 11;46(24):7706-7756
pubmed: 29177281
Apoptosis. 2003 Mar;8(2):115-28
pubmed: 12766472
Cell Death Differ. 2003 May;10(5):488-92
pubmed: 12728246
J Photochem Photobiol B. 1997 May;39(1):1-18
pubmed: 9210318
Drug Des Devel Ther. 2020 Dec 03;14:5375-5392
pubmed: 33299303
Sci Rep. 2017 Feb 22;7:43005
pubmed: 28223694
Cell Signal. 2009 Feb;21(2):228-36
pubmed: 18983913
Dalton Trans. 2018 May 15;47(19):6645-6653
pubmed: 29632935
Inorg Chem. 2022 May 9;61(18):6689-6694
pubmed: 34793162
J Inorg Biochem. 2021 Jul;220:111467
pubmed: 33932708
Chem Soc Rev. 2017 Oct 2;46(19):5771-5804
pubmed: 28654103
Chem Rev. 2009 Oct;109(10):4921-60
pubmed: 19715312
Annu Rev Genet. 2009;43:95-118
pubmed: 19659442
Mol Oncol. 2017 May;11(5):517-533
pubmed: 28258651
Cancer. 2006 Aug 1;107(3):536-43
pubmed: 16804928
Chem Rev. 2019 Jan 23;119(2):797-828
pubmed: 30295467
Am J Pathol. 2016 Apr;186(4):733-47
pubmed: 27012190
Cell Mol Life Sci. 2019 Feb;76(4):681-697
pubmed: 30382284
J Org Chem. 2004 Feb 20;69(4):1321-30
pubmed: 14961686
Front Cell Dev Biol. 2021 Mar 04;9:634690
pubmed: 33748119
J Magn Reson. 2006 Jan;178(1):42-55
pubmed: 16188474
Molecules. 2014 Sep 29;19(10):15584-610
pubmed: 25268716
Dalton Trans. 2019 Apr 9;48(15):4949-4960
pubmed: 30912797
Curr Med Chem. 2006;13(9):1085-107
pubmed: 16611086
Clin Transl Oncol. 2008 Mar;10(3):148-54
pubmed: 18321817
Front Pharmacol. 2018 Nov 19;9:1323
pubmed: 30510511
Chempluschem. 2020 Apr;85(4):659-671
pubmed: 32237220
Int J Cancer. 2017 Jun 1;140(11):2451-2460
pubmed: 28257597
J Med Chem. 2018 Jul 26;61(14):5805-5821
pubmed: 29446940
Chem Sci. 2015 May 1;6(5):2660-2686
pubmed: 29308166