The Relevance of GIRK Channels in Heart Function.
ACh
G-protein-coupled receptor
GIRK channel
IK
heart
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
09 Nov 2022
09 Nov 2022
Historique:
received:
30
09
2022
revised:
06
11
2022
accepted:
07
11
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated following the modulation of G-protein-coupled receptors and, although they have been implicated in different neurological diseases in both human and animal studies of the central nervous system, the therapeutic potential of different subtypes of these channel families in cardiac conditions has remained untapped. As they have emerged as a promising potential tool to treat a variety of conditions that disrupt neuronal homeostasis, many studies have started to focus on these channels as mediators of cardiac dynamics, thus leading to research into their implication in cardiovascular conditions. Our aim is to review the latest advances in GIRK modulation in the heart and their role in the cardiovascular system.
Identifiants
pubmed: 36363674
pii: membranes12111119
doi: 10.3390/membranes12111119
pmc: PMC9698958
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministry of Economy, Industry and Competitiveness
ID : PID2019-109425GBI00
Organisme : Ministry of Economy, Industry and Competitiveness
ID : PID2019-109425GBI00
Références
Elife. 2018 Dec 10;7:
pubmed: 30526853
Nat Commun. 2019 May 1;10(1):2008
pubmed: 31043612
Life Sci. 2020 Jan 1;240:117068
pubmed: 31751583
Int Rev Neurobiol. 2015;123:117-60
pubmed: 26422984
Nat Neurosci. 1999 Dec;2(12):1084-90
pubmed: 10570485
J Histochem Cytochem. 2001 Oct;49(10):1221-34
pubmed: 11561006
Nat Neurosci. 2009 Aug;12(8):988-95
pubmed: 19561601
Nature. 1993 Aug 26;364(6440):802-6
pubmed: 8355805
Circulation. 2001 Dec 4;104(23):2849-54
pubmed: 11733406
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):629-34
pubmed: 19118198
J Pharmacol Sci. 2006 Nov;102(3):278-87
pubmed: 17072103
Oncotarget. 2016 Dec 20;7(51):84705-84717
pubmed: 27835900
Drug Discov Today. 2012 Jul;17(13-14):654-9
pubmed: 22370250
J Neurosci. 1996 Nov 15;16(22):7137-50
pubmed: 8929423
Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50
pubmed: 12209124
Circ Res. 2010 Nov 26;107(11):1350-4
pubmed: 20884879
Neuron. 1997 Sep;19(3):687-95
pubmed: 9331358
Annu Rev Physiol. 1993;55:455-72
pubmed: 7682045
Pflugers Arch. 2021 Jun;473(6):977-981
pubmed: 34046754
Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13
pubmed: 26196595
Cardiovasc Res. 2004 Apr 1;62(1):112-21
pubmed: 15023558
Brain Res. 1997 Dec 19;778(2):251-64
pubmed: 9459542
Science. 2011 Feb 11;331(6018):768-72
pubmed: 21311022
Circ Res. 1996 Jan;78(1):1-7
pubmed: 8603491
Circ Arrhythm Electrophysiol. 2010 Oct;3(5):472-80
pubmed: 20657029
J Am Coll Cardiol. 2001 Jun 15;37(8):2136-43
pubmed: 11419900
Pharmacol Rev. 1998 Dec;50(4):723-60
pubmed: 9860808
Physiol Rev. 2010 Jan;90(1):291-366
pubmed: 20086079
Int Rev Neurobiol. 2015;123:1-26
pubmed: 26422981
Cardiovasc Res. 2007 Jun 1;74(3):426-37
pubmed: 17362895
Circulation. 2000 Nov 21;102(21):2619-28
pubmed: 11085966
Am J Hum Genet. 2010 Jun 11;86(6):872-80
pubmed: 20560207
Int Rev Neurobiol. 2015;123:87-116
pubmed: 26422983
Sci Rep. 2018 Jan 19;8(1):1192
pubmed: 29352184
Biochem Biophys Res Commun. 1995 Mar 28;208(3):1166-73
pubmed: 7702616
Front Physiol. 2012 Jun 13;3:204
pubmed: 22707940
Circulation. 2016 Aug 9;134(6):486-98
pubmed: 27462069
Nat Rev Neurosci. 2010 May;11(5):301-15
pubmed: 20389305
Neuropsychopharmacology. 2003 May;28(5):932-8
pubmed: 12637950
J Cardiovasc Pharmacol. 2014 May;63(5):421-7
pubmed: 24805146
Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H615-30
pubmed: 12124209
Mol Biol Rep. 2009 Jul;36(6):1345-52
pubmed: 18636235
Cell Physiol Biochem. 2008;21(4):259-68
pubmed: 18441514
Circ Genom Precis Med. 2019 Jan;12(1):e002238
pubmed: 30645171
Cardiovasc Drug Rev. 2007 Winter;25(4):342-56
pubmed: 18078434
Cell Rep. 2021 Aug 24;36(8):109619
pubmed: 34433062
J Physiol. 2004 Jun 1;557(Pt 2):583-97
pubmed: 15020696
Elife. 2020 Aug 26;9:
pubmed: 32844743
Neuropsychopharmacology. 2010 Jun;35(7):1560-9
pubmed: 20393461
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19977-82
pubmed: 23169654
Physiol Rev. 2014 Apr;94(2):609-53
pubmed: 24692356
J Physiol. 2008 Jul 15;586(14):3325-35
pubmed: 18499725
J Membr Biol. 1999 May 15;169(2):123-9
pubmed: 10341034
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7091-6
pubmed: 25964320
J Physiol. 2021 Jan;599(2):521-545
pubmed: 33124684
Genomics. 1994 May 1;21(1):254-6
pubmed: 8088798
J Cardiovasc Pharmacol. 2008 Feb;51(2):162-9
pubmed: 18287884
Cell Mol Life Sci. 2015 Oct;72(19):3677-93
pubmed: 26070303
Nat Commun. 2017 Jun 14;8:15805
pubmed: 28613276
J Biol Chem. 2001 Oct 5;276(40):37347-54
pubmed: 11495921
Nature. 1987 Jan 22-28;325(6102):321-6
pubmed: 2433589
World J Cardiol. 2015 Apr 26;7(4):204-14
pubmed: 25914789
Sci Rep. 2017 Jul 4;7(1):4592
pubmed: 28676630
Circulation. 2005 Dec 13;112(24):3697-706
pubmed: 16330682
J Neurosci. 1999 Feb 1;19(3):1006-17
pubmed: 9920664
Pharmacol Ther. 2021 Jul;223:107808
pubmed: 33476640
J Neurochem. 2010 Sep 1;114(5):1487-97
pubmed: 20557431
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14193-8
pubmed: 8943083
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18309-14
pubmed: 24145411
Jpn Heart J. 2003 Mar;44(2):257-70
pubmed: 12718487
Cardiovasc Res. 2014 Jan 1;101(1):175-84
pubmed: 24148898
J Physiol. 2005 Mar 1;563(Pt 2):443-57
pubmed: 15637097
Mol Cell Neurosci. 1994 Dec;5(6):515-22
pubmed: 7704424
Circ Res. 2008 Aug 29;103(5):527-35
pubmed: 18658048
Nat Neurosci. 1999 Dec;2(12):1091-7
pubmed: 10570486
Gene. 2002 Feb 6;284(1-2):241-50
pubmed: 11891065
Circulation. 2006 Apr 11;113(14):1730-7
pubmed: 16585394
Neuron. 1998 Jan;20(1):103-14
pubmed: 9459446
J Neurochem. 2021 Aug;158(4):837-848
pubmed: 33067823
Trends Pharmacol Sci. 2021 Jun;42(6):491-506
pubmed: 33858691
J Physiol. 2017 Sep 1;595(17):5895-5912
pubmed: 28715108
Cardiology. 2010;115(3):176-81
pubmed: 20110696
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6542-6
pubmed: 7604029
Cardiology. 2011;118(2):116-20
pubmed: 21555883
Hum Genet. 2012 Mar;131(3):443-51
pubmed: 21927946
Br J Pharmacol. 2003 Mar;138(6):1119-28
pubmed: 12684268
J Neurosci. 2000 Aug 1;20(15):5608-15
pubmed: 10908597
ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86
pubmed: 23730969
Front Physiol. 2018 Jul 19;9:943
pubmed: 30072916
Biomed Pharmacother. 2018 May;101:362-370
pubmed: 29499411
Trends Neurosci. 2014 Jan;37(1):20-9
pubmed: 24268819
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2533-8
pubmed: 22308486
Front Physiol. 2014 Feb 25;5:76
pubmed: 24611054
Nature. 1994 Mar 17;368(6468):255-7
pubmed: 8145826
Nature. 1995 Mar 9;374(6518):135-41
pubmed: 7877685
Cardiovasc Res. 2004 Apr 1;62(1):9-33
pubmed: 15023549
Front Pharmacol. 2021 Jan 27;11:608410
pubmed: 33584287
J Cell Biochem. 2010 Jun 1;110(3):598-608
pubmed: 20512921
FEBS Lett. 1994 Jul 11;348(2):139-44
pubmed: 8034029
Circ Res. 2010 Nov 26;107(11):1345-9
pubmed: 20864673
Cerebellum. 2020 Dec;19(6):751-761
pubmed: 32617840
Cell Rep. 2020 Jun 16;31(11):107770
pubmed: 32553165
Int Rev Neurobiol. 2015;123:27-85
pubmed: 26422982
J Neurosci. 1996 Mar 15;16(6):1990-2001
pubmed: 8604043
Cardiovasc Res. 1999 May;42(2):377-90
pubmed: 10533574
Nature. 2013 Jun 13;498(7453):190-7
pubmed: 23739333