Identification of Human Gut Microbiome Associated with Enterolignan Production.
enterolignan
gut microbiome
lignan
machine learning
metabolism
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
31 Oct 2022
31 Oct 2022
Historique:
received:
27
09
2022
revised:
26
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
12
11
2022
Statut:
epublish
Résumé
Dietary plant lignans are converted inside the gut to enterolignans enterodiol (ED) and enterolactone (EL), which have several biological functions, and health benefits. In this study, we characterized the gut microbiome composition associated with enterolignan production using data from a cross-sectional study in the Japanese population. We identified enterolignan producers by measuring ED and EL levels in subject's serum using liquid chromatography-tandem mass spectrometry. Enterolignan producers show more abundant proportion of Ruminococcaceae and Lachnospiraceae than non-enterolignan producers. In particular, subjects with EL in their serum had a highly diverse gut microbiome that was rich in Ruminococcaceae and Rikenellaceae. Moreover, we built a random forest classification model to classify subjects to either EL producers or not using three characteristic bacteria. In conclusion, our analysis revealed the composition of gut microbiome that is associated with lignan metabolism. We also confirmed that it can be used to classify the microbiome ability to metabolize lignan using machine learning approach.
Identifiants
pubmed: 36363762
pii: microorganisms10112169
doi: 10.3390/microorganisms10112169
pmc: PMC9697123
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the Japan Agency for Medical Research and Development
ID : 22ae0121035s0102
Organisme : the Japan Agency for Medical Research and Development
ID : 22gm1010006h0004
Organisme : the Japan Agency for Medical Research and Development
ID : 22ae0121042h0002
Organisme : the Japan Agency for Medical Research and Development
ID : 22ae0121035s0102
Organisme : the Ministry of Health and Welfare of Japan and Public /Private R&D Investment Strategic Expansion PrograM
ID : 20AC5004
Références
Diabetologia. 2019 Jun;62(6):959-969
pubmed: 30963187
Food Chem. 2014 May 15;151:126-32
pubmed: 24423511
Nat Commun. 2022 Aug 18;13(1):4477
pubmed: 35982037
Mucosal Immunol. 2022 Feb;15(2):289-300
pubmed: 35013573
J Proteome Res. 2016 Mar 4;15(3):1051-8
pubmed: 26809233
BMC Microbiol. 2022 Mar 29;22(1):82
pubmed: 35350985
Life Sci. 2000 Oct 27;67(23):2785-93
pubmed: 11105995
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Food Chem Toxicol. 2006 Jul;44(7):1057-64
pubmed: 16494982
Front Nutr. 2022 Mar 24;9:812469
pubmed: 35399681
Science. 2019 Jul 12;365(6449):
pubmed: 31296738
Nutrients. 2020 Jun 19;12(6):
pubmed: 32575611
Nat Med. 2020 Jun;26(6):964-973
pubmed: 32528151
Mol Nutr Food Res. 2015 Aug;59(8):1614-28
pubmed: 25988339
Appl Physiol Nutr Metab. 2016 Dec;41(12):1303-1310
pubmed: 27849354
Bioinformatics. 2011 Aug 15;27(16):2194-200
pubmed: 21700674
Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):546-54
pubmed: 25542830
Br J Pharmacol. 2017 Jun;174(11):1263-1280
pubmed: 27723080
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
BMC Microbiol. 2016 May 25;16:90
pubmed: 27220822
Eur J Nutr. 2018 Feb;57(1):1-24
pubmed: 28393285
FEMS Microbiol Ecol. 2010 Jun;72(3):507-14
pubmed: 20370826
Br J Nutr. 2008 Jun;99(6):1301-9
pubmed: 18053310
Am J Clin Nutr. 2015 Sep;102(3):695-703
pubmed: 26245807
FEMS Microbiol Ecol. 2007 Aug;61(2):372-83
pubmed: 17506823
Nutrients. 2021 Mar 12;13(3):
pubmed: 33809130
Microorganisms. 2022 Mar 20;10(3):
pubmed: 35336239
iScience. 2020 Nov 23;23(12):101841
pubmed: 33313490
Eur J Nutr. 2022 Apr;61(3):1143-1165
pubmed: 34799775
BMC Microbiol. 2021 May 20;21(1):151
pubmed: 34016052
Cell. 2020 Apr 2;181(1):92-101
pubmed: 32243801
Nature. 2014 Jun 19;510(7505):417-21
pubmed: 24896187
J Womens Health (Larchmt). 2012 Jan;21(1):92-100
pubmed: 21992596
Am J Clin Nutr. 2022 Oct 6;116(4):928-942
pubmed: 36055959
J Agric Food Chem. 2008 Jan 23;56(2):401-9
pubmed: 18163563
BMJ. 2018 Jun 13;361:k2179
pubmed: 29899036
Am J Clin Nutr. 2019 Aug 1;110(2):377-390
pubmed: 31175806
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
BMC Microbiol. 2016 Nov 28;16(1):284
pubmed: 27894251
J Nat Prod. 2014 Jan 24;77(1):29-34
pubmed: 24417583
Nat Microbiol. 2020 Jan;5(1):56-66
pubmed: 31686027
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17808-13
pubmed: 24127592
Br J Nutr. 2019 Sep 14;122(5):552-563
pubmed: 30173678
DNA Res. 2016 Apr;23(2):125-33
pubmed: 26951067
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Appl Environ Microbiol. 2005 Oct;71(10):6077-85
pubmed: 16204524
Microb Cell Fact. 2020 Apr 3;19(1):82
pubmed: 32245478
Sci Rep. 2017 Jun 28;7(1):4339
pubmed: 28659635
Cell Host Microbe. 2018 Jun 13;23(6):705-715
pubmed: 29902436