Dark Sweet Cherry (
Animals
Humans
Mice
Anthocyanins
/ pharmacology
MAP Kinase Signaling System
Mice, Inbred BALB C
Oxidative Stress
Pilot Projects
Proto-Oncogene Proteins c-akt
/ metabolism
Prunus avium
/ genetics
RNA, Messenger
/ metabolism
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
Triple Negative Breast Neoplasms
4T1-CRL-2539
angiogenesis
anthocyanins
dark sweet cherries
metastasis
polyphenols
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Oct 2022
25 Oct 2022
Historique:
received:
29
08
2022
revised:
23
09
2022
accepted:
18
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
This study aimed to assess dark sweet cherry (DSC) total polyphenols (WE) and anthocyanins (ACN) against metastatic breast cancer (BC). The WE and ACN anticancer activity and underlying mechanisms were assessed in vitro using 4T1 BC cells. A pilot study using a BALB/C mouse syngeneic model bearing 4T1 tumors assessed the anti-metastatic potential of ACN in vivo. ACN inhibited cell viability with higher potency than WE and reduced reactive oxygen species (ROS) (IC
Identifiants
pubmed: 36364072
pii: molecules27217245
doi: 10.3390/molecules27217245
pmc: PMC9657292
pii:
doi:
Substances chimiques
Anthocyanins
0
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
RNA, Messenger
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Northwest Cherry Growers
ID : M2201747
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