Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA.
16S rRNA gene profiling
anthocyanidin
blood
colorectal cancer
flavanone
flavonoids
microbiome
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 Oct 2022
27 Oct 2022
Historique:
received:
22
09
2022
revised:
14
10
2022
accepted:
17
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Flavonoids have been inversely associated to colorectal cancer (CRC) and are plausible intermediaries for the relation among gut microbiome, intestinal permeability and CRC. We analyzed the relation of flavonoid intake with CRC and blood bacterial DNA. We conducted a case-control study in Italy involving 100 incident CRC cases and 200 controls. A valid and reproducible food-frequency questionnaire was used to assess dietary habits and to estimate six flavonoid subclass intakes. We applied qPCR and 16S rRNA gene profiling to assess blood bacterial DNA. We used multiple logistic regression to derive odds ratios (ORs) of CRC and Mann-Whitney and chi--square tests to evaluate abundance and prevalence of operational taxonomic units (OTUs) according to flavonoid intakes. Inverse associations with CRC were found for anthocyanidins (OR for the highest versus the lowest tertile = 0.24, 95% confidence interval, CI = 0.11-0.52) and flavanones (OR = 0.18, 95% CI = 0.08-0.42). We found different abundance and prevalence according to anthocyanidin and flavanone intake for OTUs referring to Oligoflexales order, Diplorickettsiaceae family,
Identifiants
pubmed: 36364779
pii: nu14214516
doi: 10.3390/nu14214516
pmc: PMC9653960
pii:
doi:
Substances chimiques
Flavonoids
0
Anthocyanins
0
DNA, Bacterial
0
RNA, Ribosomal, 16S
0
Flavanones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Foundation for Cancer Research (AIRC)
ID : My First AIRC grant No.17070
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